(Q33292354)

25 July 2017

p27Kip1 localization depends on the tumor suppressor protein tuberin (English)

1 reference

25 July 2017

Gert Lubec

5

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author name string

Margit Rosner

1

1 reference

25 July 2017

Angelika Freilinger

2

1 reference

25 July 2017

Michaela Hanneder

3

1 reference

25 July 2017

Naoya Fujita

4

1 reference

25 July 2017

Takashi Tsuruo

6

1 reference

25 July 2017

Markus Hengstschläger

7

1 reference

25 July 2017

30 April 2007

1 reference

25 July 2017

Human Molecular Genetics

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25 July 2017

16

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25 July 2017

13

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25 July 2017

1541-1556

1 reference

Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase

25 July 2017

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Phosphorylation of p27Kip1 at Threonine 198 by p90 Ribosomal Protein S6 Kinases Promotes Its Binding to 14-3-3 and Cytoplasmic Localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Tuberous sclerosis: from tubers to mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Identification and characterization of the tuberous sclerosis gene on chromosome 16

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

TSC2: filling the GAP in the mTOR signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Tuberous sclerosis complex: from Drosophila to human disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

The Akt-mTOR tango and its relevance to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Akt regulates growth by directly phosphorylating Tsc2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

The TSC1 gene product, hamartin, negatively regulates cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Identification and characterization of the interaction between tuberin and 14-3-3zeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Regulation of TSC2 by 14-3-3 binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

TOR signaling in growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

p27 as a target for cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Human bladder tumors with 2-hit mutations of tumor suppressor gene TSC1 and decreased expression of p27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Tuberin and hamartin are aberrantly expressed and linked to clinical outcome in human breast cancer: the role of promoter methylation of TSC genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Tuberous sclerosis complex (TSC) gene involvement in sporadic tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Tuberous sclerosis causing mutants of the TSC2 gene product affect proliferation and p27 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Expression of wild type and mutant TSC2, but not TSC1, causes an increase in the G1 fraction of the cell cycle in HEK293 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Distinct effects of single amino-acid changes to tuberin on the function of the tuberin-hamartin complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

Akt regulates nuclear/cytoplasmic localization of tuberin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM103

21 January 2018

Identifiers

DOI

10.1093/HMG/DDM103

1 reference

25 July 2017

1 reference