(Q41978285)

14 October 2017

Inhibition of hypoxia inducible factor 1-transcription coactivator interaction by a hydrogen bond surrogate alpha-helix (English)

1 reference

14 October 2017

0 references

Laura K Henchey

1

1 reference

14 October 2017

Swati Kushal

2

1 reference

14 October 2017

Ramin Dubey

3

1 reference

14 October 2017

Ross N Chapman

4

1 reference

14 October 2017

Bogdan Z Olenyuk

5

1 reference

14 October 2017

Paramjit S Arora

6

1 reference

14 October 2017

language of work or name

English

0 references

publication date

1 January 2010

1 reference

Journal of the American Chemical Society

14 October 2017

1 reference

14 October 2017

132

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14 October 2017

3

1 reference

14 October 2017

941-943

1 reference

Direct inhibition of hypoxia-inducible transcription factor complex with designed dimeric epidithiodiketopiperazine

14 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2810346

Assessment of helical interfaces in protein-protein interactions

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2810346

Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2810346

Amphipathic small molecules mimic the binding mode and function of endogenous transcription factors

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2810346

Contemporary strategies for the stabilization of peptides in the alpha-helical conformation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2810346

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2810346

A TAD further: exogenous control of gene activation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2810346

Evaluation of biologically relevant short alpha-helices stabilized by a main-chain hydrogen-bond surrogate

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2810346

Regulation of angiogenesis by hypoxia-inducible factor 1.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2810346

Enhanced metabolic stability and protein-binding properties of artificial alpha helices derived from a hydrogen-bond surrogate: application to Bcl-xL.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2810346

A potent transactivation domain mimic with activity in living cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2810346

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2810346

A wrench-shaped synthetic molecule that modulates a transcription factor-coactivator interaction.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2810346

Nuclear localization of pyrrole–imidazole polyamide–fluorescein conjugates in cell culture

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2810346

Targeting HIF-1 for cancer therapy

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2810346

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2810346

Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2810346

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2810346

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2810346

CREB-binding protein and p300 in transcriptional regulation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2810346

The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2810346

Molecular mechanism of hypoxia-inducible factor 1alpha -p300 interaction. A leucine-rich interface regulated by a single cysteine

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2810346

A hydrogen bond surrogate approach for stabilization of short peptide sequences in alpha-helical conformation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2810346

Optimized synthesis of hydrogen-bond surrogate helices: surprising effects of microwave heating on the activity of Grubbs catalysts

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2810346

Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide

18 August 2018

1 reference

12 December 2020

Helix mimetics as inhibitors of the interaction of the estrogen receptor with coactivator peptides

1 reference

12 December 2020

Solid-phase synthesis of hydrogen-bond surrogate-derived alpha-helices

1 reference

12 December 2020

Inhibition of HIV-1 fusion by hydrogen-bond-surrogate-based alpha helices

1 reference

12 December 2020

Identifiers

DOI

10.1021/JA9082864

1 reference

14 October 2017

1 reference

14 October 2017

PubMed publication ID

20041650

1 reference