(Q41994846)

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Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression.

scientific article published on 11 April 2017

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17 March 2020

Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression (English)

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17 March 2020

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17 March 2020

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17 March 2020

Christopher Pittenger

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17 March 2020

Christine Delorenzo

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17 March 2020

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I Esterlis

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17 March 2020

N DellaGioia

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17 March 2020

R H Pietrzak

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17 March 2020

N Nabulsi

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17 March 2020

J Yang

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17 March 2020

G Sanacora

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17 March 2020

J H Krystal

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17 March 2020

R V Parsey

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17 March 2020

R E Carson

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17 March 2020

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17 March 2020

Molecular Psychiatry

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17 March 2020

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17 March 2020

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17 March 2020

824-832

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17 March 2020

https://scigraph.springernature.com/pub.10.1038/mp.2017.58

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Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects

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KETAMINE'S MECHANISM OF ACTION: A PATH TO RAPID-ACTING ANTIDEPRESSANTS.

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5 June 2018

In vivo ketamine-induced changes in [¹¹C]ABP688 binding to metabotropic glutamate receptor subtype 5.

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5 June 2018

Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeutics

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5 June 2018

Is the mGlu5 receptor a possible target for new antidepressant drugs?

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mRNA and protein expression for novel GABAA receptors θ and ρ2 are altered in schizophrenia and mood disorders; relevance to FMRP-mGluR5 signaling pathway

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5 June 2018

Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond

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A positron emission tomography study in healthy volunteers to estimate mGluR5 receptor occupancy of AZD2066 - estimating occupancy in the absence of a reference region

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Studies of the metabotropic glutamate receptor 5 radioligand [¹¹C]ABP688 with N-acetylcysteine challenge in rhesus monkeys

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Relationship of resting brain hyperconnectivity and schizophrenia-like symptoms produced by the NMDA receptor antagonist ketamine in humans

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5 June 2018

Marked global reduction in mGluR5 receptor binding in smokers and ex-smokers determined by [11C]ABP688 positron emission tomography

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NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia

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5 June 2018

Reduced metabotropic glutamate receptor 5 in the Flinders Sensitive Line of rats, an animal model of depression: an autoradiographic study

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¹H-[¹³C]-nuclear magnetic resonance spectroscopy measures of ketamine's effect on amino acid neurotransmitter metabolism

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5 June 2018

In vivo variation in metabotropic glutamate receptor subtype 5 binding using positron emission tomography and [11C]ABP688.

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5 June 2018

Region and state specific glutamate downregulation in major depressive disorder: a meta-analysis of (1)H-MRS findings.

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Quantitation of translocator protein binding in human brain with the novel radioligand [18F]-FEPPA and positron emission tomography

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Reduced metabotropic glutamate receptor 5 density in major depression determined by [(11)C]ABP688 PET and postmortem study

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Residual symptoms in depressed outpatients who respond by 50% but do not remit to antidepressant medication

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5 June 2018

In vivo positron emission tomography imaging with [¹¹C]ABP688: binding variability and specificity for the metabotropic glutamate receptor subtype 5 in baboons.

1 reference

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Glial and neuronal control of brain blood flow

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mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists

1 reference

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5 June 2018

Memory for fear extinction requires mGluR5-mediated activation of infralimbic neurons

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5 June 2018

Potential psychiatric applications of metabotropic glutamate receptor agonists and antagonists

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5 June 2018

The interactive effects of ketamine and nicotine on human cerebral blood flow

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Kinetic modeling of the serotonin 5-HT(1B) receptor radioligand [(11)C]P943 in humans

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Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders

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5 June 2018

Antidepressant-like and anxiolytic-like actions of the mGlu5 receptor antagonist MTEP, microinjected into lateral septal nuclei of male Wistar rats

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Radiosynthesis and preclinical evaluation of 11C-ABP688 as a probe for imaging the metabotropic glutamate receptor subtype 5.

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5 June 2018

Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist

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An Inventory for Measuring Depression

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5 June 2018

Activation of Metabotropic Glutamate Receptor mGlu5 on Nuclear Membranes Mediates Intranuclear Ca2+ Changes in Heterologous Cell Types and Neurons

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5 June 2018

Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268.

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5 June 2018

Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist

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5 June 2018

Differential subcellular localization of mGluR1a and mGluR5 in the rat and monkey Substantia nigra.

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5 June 2018

Antidepressant effects of ketamine in depressed patients

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5 June 2018

Novelty acquisition is associated with induction of hippocampal long-term depression.

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Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus

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5 June 2018

Association of ketamine-induced psychosis with focal activation of the prefrontal cortex in healthy volunteers

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5 June 2018

Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex.

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Metabolic hyperfrontality and psychopathology in the ketamine model of psychosis using positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG).

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Costimulation of AMPA and metabotropic glutamate receptors underlies phospholipase C activation by glutamate in hippocampus.

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Binding potential of (E)-[¹¹C]ABP688 to metabotropic glutamate receptor subtype 5 is decreased by the inclusion of its ¹¹C-labelled Z-isomer.

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Different effects of the NMDA receptor antagonists ketamine, MK-801, and memantine on postsynaptic density transcripts and their topography: role of Homer signaling, and implications for novel antipsychotic and pro-cognitive targets in psychosis

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Acute and sustained effects of a metabotropic glutamate 5 receptor antagonist in the novelty-suppressed feeding test

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Sequenced Treatment Alternatives to Relieve Depression (STAR*D): lessons learned.

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Measurement of striatal and extrastriatal dopamine transporter binding with high-resolution PET and [11C]PE2I: quantitative modeling and test-retest reproducibility

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18 August 2018

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18 August 2018

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18 August 2018

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18 August 2018

Anxiolytic-like effects of the selective metabotropic glutamate receptor 5 antagonist MPEP after its intra-amygdaloid microinjection in three different non-conditioned rat models of anxiety.

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18 August 2018

Group I metabotropic glutamate receptors activate the p70S6 kinase via both mammalian target of rapamycin (mTOR) and extracellular signal-regulated kinase (ERK 1/2) signaling pathways in rat striatal and hippocampal synaptoneurosomes.

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18 August 2018

Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression.

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18 August 2018

Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression

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18 August 2018

A three-factor analytic model of the MADRS in geriatric depression.

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18 August 2018

Effect of chronic imipramine or electroconvulsive shock on the expression of mGluR1a and mGluR5a immunoreactivity in rat brain hippocampus.

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18 August 2018

Differential distribution of group I metabotropic glutamate receptors during rat cortical development

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18 August 2018

Changes in the expression of metabotropic glutamate receptor 5 (mGluR5) in the rat hippocampus in an animal model of depression.

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18 August 2018

The arrangement of glutamate receptors in excitatory synapses

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18 August 2018

The metabotropic glutamate receptor 1 is not involved in the facilitation of glutamate release in cerebrocortical nerve terminals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5636649

18 August 2018

Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5636649

2 December 2018

Imaging changes in glutamate transmission in vivo with the metabotropic glutamate receptor 5 tracer [11C] ABP688 and N-acetylcysteine challenge

1 reference

https://api.crossref.org/works/10.1038%2FMP.2017.58

7 January 2021

based on heuristic

inferred from DOI database lookup

Measurement of dissociative states with the Clinician-Administered Dissociative States Scale (CADSS)

1 reference

https://api.crossref.org/works/10.1038%2FMP.2017.58

7 January 2021

based on heuristic

inferred from DOI database lookup

A new method for assessing PET-MRI coregistration

1 reference

https://api.crossref.org/works/10.1038%2FMP.2017.58

7 January 2021

based on heuristic

inferred from DOI database lookup

In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [11C]ABP688 and [18F]FPEB.

1 reference

https://api.crossref.org/works/10.1038%2FMP.2017.58

7 January 2021

based on heuristic

inferred from DOI database lookup

Chronic, systemic treatment with a metabotropic glutamate receptor 5 antagonist produces anxiolytic-like effects and reverses abnormal firing activity of projection neurons in the basolateral nucleus of the amygdala in rats with bilateral 6-OHDA les

1 reference

https://api.crossref.org/works/10.1038%2FMP.2017.58

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/MP.2017.58

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28397841%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28397841%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28397841%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

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