(Q42028885)

English

Reduction of hydrophilic ubiquinones by the flavin in mitochondrial NADH:ubiquinone oxidoreductase (Complex I) and production of reactive oxygen species

scientific article published on March 2009

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scholarly article

1 reference

Europe PubMed Central

15 October 2017

Reduction of hydrophilic ubiquinones by the flavin in mitochondrial NADH:ubiquinone oxidoreductase (Complex I) and production of reactive oxygen species (English)

1 reference

Europe PubMed Central

15 October 2017

reactive oxygen species

1 reference

based on heuristic

inferred from title

object named as

Martin S King

1

0 references

object named as

Judy Hirst

3

0 references

author name string

Mark S Sharpley

2

1 reference

Europe PubMed Central

15 October 2017

language of work or name

0 references

publication date

1 March 2009

1 reference

Europe PubMed Central

15 October 2017

1 reference

Europe PubMed Central

15 October 2017

48

1 reference

Europe PubMed Central

15 October 2017

9

1 reference

Europe PubMed Central

15 October 2017

2053-2062

1 reference

Europe PubMed Central

15 October 2017

Drug Insight: antioxidant therapy in inherited ataxias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

5 June 2018

Flavin-dependent quinone reductases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

5 June 2018

Reevaluating the relationship between EPR spectra and enzyme structure for the iron sulfur clusters in NADH:quinone oxidoreductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

5 June 2018

Adriamycin-induced oxidative mitochondrial cardiotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

5 June 2018

Bovine complex I is a complex of 45 different subunits.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

5 June 2018

Energy converting NADH:quinone oxidoreductase (complex I).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

5 June 2018

The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

5 June 2018

Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

5 June 2018

Energy transduction by respiratory complex I--an evaluation of current knowledge

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

5 June 2018

The nuclear encoded subunits of complex I from bovine heart mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

5 June 2018

A cellular model for Friedreich Ataxia reveals small-molecule glutathione peroxidase mimetics as novel treatment strategy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

5 June 2018

Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

5 June 2018

GRIM-19, a cell death regulatory gene product, is a subunit of bovine mitochondrial NADH:ubiquinone oxidoreductase (complex I)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

5 June 2018

Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: species comparison and structural changes with substrate binding and release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

5 June 2018

NADH-quinone oxidoreductase: PSST subunit couples electron transfer from iron-sulfur cluster N2 to quinone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

5 June 2018

The specificity of mitochondrial complex I for ubiquinones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

5 June 2018

Partial resolution of the enzymes catalyzing oxidative phosphorylation. VII. Oxidative phosphorylation in the diphosphopyridine nucleotide-cytochrome b segment of the respiratory chain: assay and properties in submitochondrial particles.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

5 June 2018

Resolution and reconstitution of the mitochondrial electron transport system. IV. The reconstitution of rotenone-sensitive reduced nicotinamide adenine dinucleotide-ubiquinone reductase from reduced nicotinamide adenine dinucleotide dehydrogenase an

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

5 June 2018

Photolabelling of a mitochondrially encoded subunit of NADH dehydrogenase with [3H]dihydrorotenone.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

5 June 2018

Slow active/inactive transition of the mitochondrial NADH-ubiquinone reductase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

5 June 2018

On the mechanism of rotenone-insensitive reduction of quinones by mitochondrial NADH:ubiquinone reductase. The high affinity binding of NAD+ and NADH to the reduced enzyme form.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

5 June 2018

The role of phospholipids in the reduction of ubiquinone analogues by the mitochondrial reduced nicotinamide-adenine dinucleotide-ubiquinone oxidoreductase complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

5 June 2018

The use of acetylated ferricytochrome C for the detection of superoxide radicals produced in biological membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

5 June 2018

Reduction of the iron-sulfur clusters in mitochondrial NADH:ubiquinone oxidoreductase (complex I) by EuII-DTPA, a very low potential reductant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

17 August 2018

Modification of respiratory-chain enzyme activities in brown adipose tissue mitochondria by idebenone (hydroxydecyl-ubiquinone).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

17 August 2018

Complex I is the major site of mitochondrial superoxide production by paraquat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

17 August 2018

Transhydrogenation reactions catalyzed by mitochondrial NADH-ubiquinone oxidoreductase (Complex I).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

17 August 2018

The ND1 subunit constructs the inhibitor binding domain in bovine heart mitochondrial complex I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

17 August 2018

Interactions between phospholipids and NADH:ubiquinone oxidoreductase (complex I) from bovine mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

17 August 2018

HDQ (1-hydroxy-2-dodecyl-4(1H)quinolone), a high affinity inhibitor for mitochondrial alternative NADH dehydrogenase: evidence for a ping-pong mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

17 August 2018

Detection of hydrogen peroxide with Amplex Red: interference by NADH and reduced glutathione auto-oxidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

17 August 2018

Biomedicine. Parkinson's--divergent causes, convergent mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

17 August 2018

Functional implications from an unexpected position of the 49-kDa subunit of NADH:ubiquinone oxidoreductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

17 August 2018

The ND5 subunit was labeled by a photoaffinity analogue of fenpyroximate in bovine mitochondrial complex I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

17 August 2018

Full recovery of the NADH:ubiquinone activity of complex I (NADH:ubiquinone oxidoreductase) from Yarrowia lipolytica by the addition of phospholipids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

17 August 2018

The second coenzyme Q1 binding site of bovine heart NADH: coenzyme Q oxidoreductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

17 August 2018

The site of production of superoxide radical in mitochondrial Complex I is not a bound ubisemiquinone but presumably iron-sulfur cluster N2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

17 August 2018

The 49-kDa subunit of NADH-ubiquinone oxidoreductase (Complex I) is involved in the binding of piericidin and rotenone, two quinone-related inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

17 August 2018

Steady-state kinetics of the reduction of coenzyme Q analogs by complex I (NADH:ubiquinone oxidoreductase) in bovine heart mitochondria and submitochondrial particles.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

17 August 2018

The Interaction of Q Analogs, Particularly Hydroxydecyl Benzoquinone (Idebenone), with the Respiratory Complexes of Heart Mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2651670

2 December 2018

Proton pumping of mitochondrial complex I: differential activation by analogs of ubiquinone

1 reference

https://pubmed.ncbi.nlm.nih.gov/19220002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quinone specificity of complex I

1 reference

https://pubmed.ncbi.nlm.nih.gov/19220002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of NADH-ubiquinone reductase: an overview

1 reference

https://pubmed.ncbi.nlm.nih.gov/19220002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-activity relationships of some complex I inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19220002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the isoprenyl tail of ubiquinone in reaction with respiratory enzymes: studies with bovine heart mitochondrial complex I and Escherichia coli bo-type ubiquinol oxidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19220002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the respiratory chain-linked dihydrodiphosphopyridine nucleotide dehydrogenase. I. Assay of the enzyme in particulate and in soluble preparations

1 reference

https://pubmed.ncbi.nlm.nih.gov/19220002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiolipin requirement for electron transfer in complex I and III of the mitochondrial respiratory chain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19220002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome c reduction by semiquinone radicals can be indirectly inhibited by superoxide dismutase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19220002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of site I redox-driven H+ pump by exogenous quinones in intact mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/19220002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Superoxide Radical Formation by Pure Complex I (NADH:Ubiquinone Oxidoreductase) fromYarrowia lipolytica

1 reference

https://pubmed.ncbi.nlm.nih.gov/19220002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exploring the Ubiquinone Binding Cavity of Respiratory Complex I

1 reference

https://pubmed.ncbi.nlm.nih.gov/19220002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New evidence for the multiplicity of ubiquinone- and inhibitor-binding sites in the mitochondrial complex I

1 reference

https://pubmed.ncbi.nlm.nih.gov/19220002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assay conditions for the mitochondrial NADH:coenzyme Q oxidoreductase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19220002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thermodynamic analysis of flavin in mitochondrial NADH:ubiquinone oxidoreductase (complex I)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19220002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI802282H

1 reference

Europe PubMed Central

15 October 2017

1 reference

Europe PubMed Central

15 October 2017

1 reference

Europe PubMed Central

15 October 2017

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