(Q42031194)

15 October 2017

Novel PEGylated basal insulin LY2605541 has a preferential hepatic effect on glucose metabolism (English)

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15 October 2017

1 reference

7

Alan D Cherrington

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15 October 2017

Mary E. Courtney Moore

1

object named as

Mary Courtney Moore

1 reference

15 October 2017

2

Marta S Smith

1 reference

15 October 2017

Vikram P Sinha

3

1 reference

15 October 2017

John M Beals

4

1 reference

15 October 2017

M Dodson Michael

5

1 reference

15 October 2017

Scott J Jacober

6

1 reference

15 October 2017

language of work or name

English

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publication date

2 October 2013

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15 October 2017

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15 October 2017

63

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15 October 2017

2

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15 October 2017

494-504

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

15 October 2017

start time

30 August 2021

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5361402/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Insulin degludec improves glycaemic control with lower nocturnal hypoglycaemia risk than insulin glargine in basal-bolus treatment with mealtime insulin aspart in Type 1 diabetes (BEGIN(®) Basal-Bolus Type 1): 2-year results of a randomized clinical

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Better glycemic control and weight loss with the novel long-acting basal insulin LY2605541 compared with insulin glargine in type 1 diabetes: a randomized, crossover study

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Interaction between the central and peripheral effects of insulin in controlling hepatic glucose metabolism in the conscious dog.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Design of non-standard insulin analogs for the treatment of diabetes mellitus

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

A randomized, controlled study of once-daily LY2605541, a novel long-acting basal insulin, versus insulin glargine in basal insulin-treated patients with type 2 diabetes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Brain meets body: the blood-brain barrier as an endocrine interface

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Design of the novel protraction mechanism of insulin degludec, an ultra-long-acting basal insulin.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

A high-fat, high-fructose diet accelerates nutrient absorption and impairs net hepatic glucose uptake in response to a mixed meal in partially pancreatectomized dogs

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Hypoglycemia rates with basal insulin analogs

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Optimizing the replacement of basal insulin in type 1 diabetes mellitus: no longer an elusive goal in the post-NPH era.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

The future of basal insulin supplementation.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Comparison of insulins detemir and glargine: effects on glucose disposal, hepatic glucose release and the central nervous system

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Insulin degludec in type 1 diabetes: a randomized controlled trial of a new-generation ultra-long-acting insulin compared with insulin glargine.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Insulin-induced hypoglycemia increases hepatic sensitivity to glucagon in dogs

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Insulin detemir is not transported across the blood-brain barrier

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Mechanisms of insulin resistance after insulin-induced hypoglycemia in humans: the role of lipolysis

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Molecular characterization of insulin-mediated suppression of hepatic glucose production in vivo

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Effects of insulin on the metabolic control of hepatic gluconeogenesis in vivo.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Characteristics of compounds that cross the blood-brain barrier

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

A physiological increase in the hepatic glycogen level does not affect the response of net hepatic glucose uptake to insulin

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Kinetic determinants of hepatic clearance: plasma protein binding and hepatic uptake

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Effects of vagal blockade on the counterregulatory response to insulin-induced hypoglycemia in the dog.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

In the absence of counterregulatory hormones, the increase in hepatic glucose production during insulin-induced hypoglycemia in the dog is initiated in the liver rather than the brain.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Demonstration of a critical role for free fatty acids in mediating counterregulatory stimulation of gluconeogenesis and suppression of glucose utilization in humans

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Growth hormone and diabetes mellitus. A review of sixty-three years of medical research and a glimpse into the future?

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Role of hepatic STAT3 in brain-insulin action on hepatic glucose production.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Tissue selectivity of insulin detemir action in vivo.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

A circulatory model for calculating non-steady-state glucose fluxes. Validation and comparison with compartmental models

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Direct and indirect effects of insulin on glucose uptake and storage by the liver

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

A negative arterial-portal venous glucose gradient decreases skeletal muscle glucose uptake.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Basal hepatic glucose production is regulated by the portal vein insulin concentration.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Serum proteins bypass the blood-brain fluid barriers for extracellular entry to the central nervous system.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Blood to brain and brain to blood passage of native horseradish peroxidase, wheat germ agglutinin, and albumin: pharmacokinetic and morphological assessments.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5361402

Ultra-long-acting insulin degludec has a flat and stable glucose-lowering effect in type 2 diabetes

17 August 2018

1 reference

12 December 2020

The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog

1 reference

12 December 2020

Novel hepatoselective insulin analog: studies with a covalently linked thyroxyl-insulin complex in humans

1 reference

12 December 2020

A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog

1 reference

12 December 2020

Alcohol Intake Impairs Glucose Counterregulation During Acute Insulin-Induced Hypoglycemia in IDDM Patients: Evidence for a Critical Role of Free Fatty Acids

1 reference

12 December 2020

Albumin binding and time action of acylated insulins in various species

1 reference

12 December 2020

Impact of chronic stress hormone infusion on hepatic carbohydrate metabolism in the conscious dog

1 reference

12 December 2020

First-pass hepatic extraction and metabolic effects of insulin and insulin analogues

1 reference

12 December 2020

Neural and pancreatic influences on net hepatic glucose uptake and glycogen synthesis

1 reference

12 December 2020

Intraperitoneal insulin affects insulin-like growth factor binding protein-1 in a well-controlled type I diabetic patient

1 reference

12 December 2020

A negative arterial-portal venous glucose gradient increases net hepatic glucose uptake in euglycemic dogs

1 reference

12 December 2020

Metabolic regulation in peripheral tissues and transition to increased gluconeogenic mode during prolonged exercise

1 reference

12 December 2020

Effect of hepatic denervation on the counterregulatory response to insulin-induced hypoglycemia in the dog

1 reference

12 December 2020

Identifiers

DOI

10.2337/DB13-0826

1 reference

15 October 2017

1 reference

15 October 2017

PubMed publication ID

24089512

1 reference