(Q42042649)

15 October 2017

Trimeric tau is toxic to human neuronal cells at low nanomolar concentrations (English)

1 reference

15 October 2017

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24159335%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

author name string

Huilai Tian

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24159335%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Eliot Davidowitz

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24159335%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Patricia Lopez

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24159335%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Sharareh Emadi

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24159335%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

James Moe

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24159335%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

publication date

17 September 2013

1 reference

International Journal of Cell Biology

15 October 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24159335%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

volume

2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24159335%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

page(s)

260787

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24159335%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 3.0 Unported

3 June 2020

copyright license

start time

1 January 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

cites work

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Isolation and characterization of antibody fragments selective for specific protein morphologies from nanogram antigen samples

5 June 2018

1 reference

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Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons

5 June 2018

1 reference

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Pathogenesis and disease-modifying therapy in Alzheimer's disease: the flat line of progress

5 June 2018

1 reference

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Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

5 June 2018

1 reference

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Current application of neurochemical biomarkers in the prediction and differential diagnosis of Alzheimer's disease and other neurodegenerative dementias.

5 June 2018

1 reference

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Tau oligomers and tau toxicity in neurodegenerative disease

5 June 2018

1 reference

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Effect of immunotherapy with bapineuzumab on cerebrospinal fluid biomarker levels in patients with mild to moderate Alzheimer disease

5 June 2018

1 reference

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5 June 2018

1 reference

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Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

5 June 2018

1 reference

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CSF levels of oligomeric alpha-synuclein and beta-amyloid as biomarkers for neurodegenerative disease

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice.

5 June 2018

1 reference

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5 June 2018

The many faces of tau

1 reference

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The cholinergic system in aging and neuronal degeneration

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Tissue-nonspecific alkaline phosphatase promotes the neurotoxicity effect of extracellular tau

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Early Tau pathology involving the septo-hippocampal pathway in a Tau transgenic model: relevance to Alzheimer's disease.

5 June 2018

1 reference

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Detecting morphologically distinct oligomeric forms of alpha-synuclein

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Tau oligomerization: a role for tau aggregation intermediates linked to neurodegeneration

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Anti-oligomeric Abeta single-chain variable domain antibody blocks Abeta-induced toxicity against human neuroblastoma cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Evidence that non-fibrillar tau causes pathology linked to neurodegeneration and behavioral impairments

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Early axonopathy preceding neurofibrillary tangles in mutant tau transgenic mice

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Isolation of a human single chain antibody fragment against oligomeric alpha-synuclein that inhibits aggregation and prevents alpha-synuclein-induced toxicity

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Isolating recombinant antibodies against specific protein morphologies using atomic force microscopy and phage display technologies

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Vulnerability of cortical neurons to Alzheimer's and Parkinson's diseases.

5 June 2018

1 reference

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Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy

5 June 2018

1 reference

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Common mechanisms of amyloid oligomer pathogenesis in degenerative disease

5 June 2018

1 reference

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Increased levels of granular tau oligomers: an early sign of brain aging and Alzheimer's disease

5 June 2018

1 reference

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Tau suppression in a neurodegenerative mouse model improves memory function

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.

5 June 2018

1 reference

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Terminally differentiated SH-SY5Y cells provide a model system for studying neuroprotective effects of dopamine agonists.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Frequency of stages of Alzheimer-related lesions in different age categories

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Differentiation and survival influences of growth factors in human neuroblastoma

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Alzheimer's disease: the amyloid cascade hypothesis

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Tubulin requires tau for growth onto microtubule initiating sites

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

A protein factor essential for microtubule assembly

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

39-week toxicity and toxicokinetic study of ponezumab (PF-04360365) in cynomolgus monkeys with 12-week recovery period.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Accumulation of pathological tau species and memory loss in a conditional model of tauopathy.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Single chain Fv antibodies against the 25-35 Abeta fragment inhibit aggregation and toxicity of Abeta42.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Microtubule structure and its stabilisation

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Promotion of hyperphosphorylation by frontotemporal dementia tau mutations

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Neurons may live for decades with neurofibrillary tangles.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Tau in Alzheimer's disease.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789488

Characterizing antibody specificity to different protein morphologies by AFM

17 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24159335

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The pathological process underlying Alzheimer's disease in individuals under thirty

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24159335

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1155/2013/260787

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24159335%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24159335%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24159335%20AND%20SRC:MED&resulttype=core&format=json