(Q42056048)

English

Butein inhibits ethanol-induced activation of liver stellate cells through TGF-β, NFκB, p38, and JNK signaling pathways and inhibition of oxidative stress

scientific article published on 22 June 2012

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

Butein inhibits ethanol-induced activation of liver stellate cells through TGF-β, NFκB, p38, and JNK signaling pathways and inhibition of oxidative stress (English)

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

Jadwiga Daniluk

object named as

Jadwiga Daniluk

3

0 references

Agnieszka Szuster-Ciesielska

1

object named as

Agnieszka Szuster-Ciesielska

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

Martyna Kandefer-Szerszeń

4

object named as

Martyna Kandefer-Szerszeń

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

Magdalena Mizerska-Dudka

2

object named as

Magdalena Mizerska-Dudka

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

publication date

22 June 2012

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

Journal of Gastroenterology

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

48

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

2

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

222-237

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3575555/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Alcoholic liver disease: pathogenesis and new therapeutic targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575555

5 June 2018

Butein inhibits the migration and invasion of SK-HEP-1 human hepatocarcinoma cells through suppressing the ERK, JNK, p38, and uPA signaling multiple pathways

1 reference

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5 June 2018

Selenium supplementation attenuates procollagen-1 and interleukin-8 production in fat-loaded human C3A hepatoblastoma cells treated with TGFbeta1.

1 reference

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5 June 2018

TGF-beta signaling in alcohol induced hepatic injury

1 reference

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Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition

1 reference

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Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations.

1 reference

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A novel anticancer effect of butein: inhibition of invasion through the ERK1/2 and NF-kappa B signaling pathways in bladder cancer cells

1 reference

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5 June 2018

Zinc inhibits ethanol-induced HepG2 cell apoptosis.

1 reference

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Selective inactivation of NF-kappaB in the liver using NF-kappaB decoy suppresses CCl4-induced liver injury and fibrosis

1 reference

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Matrix metalloproteinases, the pros and cons, in liver fibrosis

1 reference

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Involvement of integrin-linked kinase in carbon tetrachloride-induced hepatic fibrosis in rats

1 reference

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5 June 2018

Molecular mechanisms of alcohol-induced hepatic fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575555

5 June 2018

Early response of alpha2(I) collagen to acetaldehyde in human hepatic stellate cells is TGF-beta independent

1 reference

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5 June 2018

Hepatitis C virus-replicating hepatocytes induce fibrogenic activation of hepatic stellate cells.

1 reference

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5 June 2018

Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization

1 reference

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Transforming growth factor-beta and platelet-derived growth factor signal via c-Jun N-terminal kinase-dependent Smad2/3 phosphorylation in rat hepatic stellate cells after acute liver injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575555

5 June 2018

1 reference

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5 June 2018

Structure and function of hepatic stellate cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575555

5 June 2018

Role of reactive oxygen species, glutathione and NF-kappaB in apoptosis induced by 3,4-methylenedioxymethamphetamine ("Ecstasy") on hepatic stellate cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575555

5 June 2018

Identification of a novel NF-kappaB-binding site with regulation of the murine alpha2(I) collagen promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575555

5 June 2018

Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta ) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent.

1 reference

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5 June 2018

Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover

1 reference

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5 June 2018

p38 MAPK mediates the regulation of alpha1(I) procollagen mRNA levels by TNF-alpha and TGF-beta in a cell line of rat hepatic stellate cells(1).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575555

5 June 2018

Aldehydes potentiate alpha(2)(I) collagen gene activity by JNK in hepatic stellate cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575555

5 June 2018

Ethanol and arachidonic acid increase alpha 2(I) collagen expression in rat hepatic stellate cells overexpressing cytochrome P450 2E1. Role of H2O2 and cyclooxygenase-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575555

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Quantitative analysis of constitutive and inducible CYPs mRNA expression in the HepG2 cell line using reverse transcription-competitive PCR.

1 reference

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5 June 2018

Hydrogen peroxide: a link between acetaldehyde-elicited alpha1(I) collagen gene up-regulation and oxidative stress in mouse hepatic stellate cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575555

5 June 2018

Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575555

5 June 2018

NF-kappaB inhibits expression of the alpha1(I) collagen gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575555

5 June 2018

Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575555

5 June 2018

Acetaldehyde enhances murine alpha2(I) collagen promoter activity by Ca2+-independent protein kinase C activation in cultured rat hepatic stellate cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575555

5 June 2018

Transforming growth factor beta1 induces the expression of alpha1(I) procollagen mRNA by a hydrogen peroxide-C/EBPbeta-dependent mechanism in rat hepatic stellate cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575555

5 June 2018

Respective roles of human cytochrome P-4502E1, 1A2, and 3A4 in the hepatic microsomal ethanol oxidizing system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575555

5 June 2018

Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver.

1 reference

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The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors

1 reference

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Establishment of a recombinant hepatic cell line stably expressing alcohol dehydrogenase

1 reference

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1 reference

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Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1. Implications for regulation of matrix degradation in liver

1 reference

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Expression of Cytochromes P-450 2E1, 3A4 and 1A1/1A2 in Growing and Confluent Human HepG2 Hepatoma Cells-Effect of Ethanol

1 reference

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Reactive oxygen species (ROS) mediate the effects of leucine on translation regulation and type I collagen production in hepatic stellate cells.

1 reference

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Butein suppresses bile acid-induced hepatocyte apoptosis through a JNK-dependent but ERK-independent pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575555

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Impaired proteolysis of collagen I inhibits proliferation of hepatic stellate cells: implications for regulation of liver fibrosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575555

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2',4',6'-Tris(methoxymethoxy) chalcone attenuates hepatic stellate cell proliferation by a heme oxygenase-dependent pathway.

1 reference

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Ethanol rapidly causes activation of JNK associated with ER stress under inhibition of ADH.

1 reference

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Immunohistochemical distribution of activated nuclear factor kappaB and peroxisome proliferator-activated receptors in carbon tetrachloride-induced chronic liver injury in rats.

1 reference

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SMAD and p38 MAPK signaling pathways independently regulate alpha1(I) collagen gene expression in unstimulated and transforming growth factor-beta-stimulated hepatic stellate cells.

1 reference

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Effects of acetaldehyde and TNF alpha on the inhibitory kappa B-alpha protein and nuclear factor kappa B activation in hepatic stellate cells

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The chalcone butein from Rhus verniciflua shows antifibrogenic activity

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1 reference

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Pancreatic stellate cell activation by ethanol and acetaldehyde: is it mediated by the mitogen-activated protein kinase signaling pathway?

1 reference

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Butein suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture

1 reference

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Alcohol activates activator protein-1 and mitogen-activated protein kinases in rat pancreatic stellate cells

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1 reference

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Intracellular signaling pathways involved in acetaldehyde-induced collagen and fibronectin gene expression in human hepatic stellate cells

1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/22722906

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Glutathione Levels Discriminate between Oxidative Stress and Transforming Growth Factor-β Signaling in Activated Rat Hepatic Stellate Cells

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Tissue inhibitor of metalloproteinase-I and interstitial collagenase expression in autoimmune chronic active hepatitis and activated human hepatic lipocytes

1 reference

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Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue

1 reference

https://pubmed.ncbi.nlm.nih.gov/22722906

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Ethanol oxidation into acetaldehyde by 16 recombinant human cytochrome P450 isoforms: role of CYP2C isoforms in human liver microsomes

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00535-012-0619-7

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

ResearchGate publication ID

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