(Q42058134)

English

High throughput screening against the peroxidase cascade of African trypanosomes identifies antiparasitic compounds that inactivate tryparedoxin

scientific article published on 23 January 2012

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

High throughput screening against the peroxidase cascade of African trypanosomes identifies antiparasitic compounds that inactivate tryparedoxin (English)

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

author name string

Florian Fueller

1

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

Britta Jehle

2

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

Kerstin Putzker

3

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

Joe D Lewis

4

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

R Luise Krauth-Siegel

5

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

language of work or name

0 references

publication date

23 January 2012

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

number of pages

11

1 reference

based on heuristic

inferred from page(s)

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

287

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

12

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

8792-8802

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

The resurgence of covalent drugs

1 reference

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Antitumor quinol PMX464 is a cytocidal anti-trypanosomal inhibitor targeting trypanothione metabolism

1 reference

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Structure ofMycobacterium tuberculosisthioredoxin in complex with quinol inhibitor PMX464

1 reference

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1 reference

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New therapeutic targets for drug design against Trypanosoma cruzi, advances and perspectives.

1 reference

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Preparative enzymatic synthesis of trypanothione and trypanothione analogues.

1 reference

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Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity

1 reference

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Structural Basis for a Distinct Catalytic Mechanism in Trypanosoma brucei Tryparedoxin Peroxidase

1 reference

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Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy

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1 reference

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Peroxidases of trypanosomatids

1 reference

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Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism

1 reference

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Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade

1 reference

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A cellular and molecular investigation of the action of PMX464, a putative thioredoxin inhibitor, in normal and colorectal cancer cell lines.

1 reference

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Evaluation of different glutathione S-transferase-tagged protein captures for screening E6/E6AP interaction inhibitors using AlphaScreen

1 reference

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High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity

1 reference

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Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomes

1 reference

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Elucidation of thioredoxin as a molecular target for antitumor quinols.

1 reference

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Dithiol proteins as guardians of the intracellular redox milieu in parasites: old and new drug targets in trypanosomes and malaria-causing plasmodia

1 reference

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Identification and characterization of TRP14, a thioredoxin-related protein of 14 kDa. New insights into the specificity of thioredoxin function

1 reference

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RNA interference identifies two hydroperoxide metabolizing enzymes that are essential to the bloodstream form of the african trypanosome.

1 reference

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Kinetics and Redox-Sensitive Oligomerisation Reveal Negative Subunit Cooperativity in Tryparedoxin Peroxidase of Trypanosoma brucei brucei

1 reference

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5 June 2018

Structures of tryparedoxins revealing interaction with trypanothione

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308743

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

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Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase

1 reference

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

1 reference

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Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress

1 reference

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The high resolution crystal structure of recombinant Crithidia fasciculata tryparedoxin-I

1 reference

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A unique cascade of oxidoreductases catalyses trypanothione-mediated peroxide metabolism in Crithidia fasciculata

1 reference

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Cloning, sequencing, overproduction and purification of trypanothione reductase from Trypanosoma cruzi.

1 reference

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Metabolism and functions of trypanothione in the Kinetoplastida

1 reference

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A tryparedoxin-dependent peroxidase protects African trypanosomes from membrane damage

1 reference

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Functional characterization of methionine sulfoxide reductase A from Trypanosoma spp.

1 reference

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1 reference

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1H, 13C, and 15N assignment of the oxidized and reduced forms of T. brucei glutathione peroxidase-type tryparedoxin peroxidase.

1 reference

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Catalytic mechanism of the glutathione peroxidase-type tryparedoxin peroxidase of Trypanosoma brucei

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Trypanosoma brucei tryparedoxin, a thioredoxin-like protein in African trypanosomes.

1 reference

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Trypanothione-dependent peroxide metabolism in Trypanosoma cruzi different stages.

1 reference

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2 references

https://api.crossref.org/works/10.1074%2FJBC.M111.338285

21 January 2018

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Improved Inhibitors of Trypanothione Reductase by Combination of Motifs: Synthesis, Inhibitory Potency, Binding Mode, and Antiprotozoal Activities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.338285

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Rapid desalting of protein samples for on-line microflow electrospray ionization mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/22275351

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catalytic characteristics of tryparedoxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22275351

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.338285

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

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