(Q58848500)

English

Improved Inhibitors of Trypanothione Reductase by Combination of Motifs: Synthesis, Inhibitory Potency, Binding Mode, and Antiprotozoal Activities

scientific article published on 16 December 2010

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21275053%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Improved inhibitors of trypanothione reductase by combination of motifs: synthesis, inhibitory potency, binding mode, and antiprotozoal activities (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21275053%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Daniel Fankhauser

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21275053%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21275053%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

5

object named as

Reto Brun

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21275053%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

François Diederich

7

object named as

François Diederich

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21275053%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

author name string

Christian Eberle

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21275053%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Birgit Sophia Lauber

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21275053%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

R Luise Krauth-Siegel

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21275053%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

publication date

16 December 2010

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21275053%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21275053%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21275053%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21275053%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

292-301

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21275053%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Chagas disease: a new worldwide challenge.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Chemotherapy of human African trypanosomiasis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Kinetoplastids: related protozoan pathogens, different diseases

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Chemotherapy of human African trypanosomiasis: current and future prospects

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

The fall and rise of sleeping sickness

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Drug resistance in leishmaniasis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Dithiol proteins as guardians of the intracellular redox milieu in parasites: old and new drug targets in trypanosomes and malaria-causing plasmodia

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Parasite-specific trypanothione reductase as a drug target molecule

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Target assessment for antiparasitic drug discovery

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Metabolism and functions of trypanothione in the Kinetoplastida

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Picking pockets to fuel antimicrobial drug discovery

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Synthesis, inhibition potency, binding mode, and antiprotozoal activities of fluorescent inhibitors of trypanothione reductase based on mepacrine-conjugated diaryl sulfide scaffolds

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structures

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Use of an additional hydrophobic binding site, the Z site, in the rational drug design of a new class of stronger trypanothione reductase inhibitor, quaternary alkylammonium phenothiazines

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug design

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Diaryl sulfide-based inhibitors of trypanothione reductase: inhibition potency, revised binding mode and antiprotozoal activities

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

MAB, a generally applicable molecular force field for structure modelling in medicinal chemistry.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Docking and molecular dynamics simulation of quinone compounds with trypanocidal activity.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Structure-activity relationship study to understand the estrogen receptor-dependent gene activation of aryl- and alkyl-substituted 1H-imidazoles

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Synthesis and biological evaluation of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine homologues at dopamine-uptake and phencyclidine- and sigma-binding sites

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Design of new potent and selective secretory phospholipase A2 inhibitors. Part 5: synthesis and biological activity of 1-alkyl-4-[4,5-dihydro-1,2,4-[4H]-oxadiazol-5-one-3-ylmethylbenz-4'-yl(oyl)] piperazines

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Regioselective synthesis of 1-(2,6-dichloro-4-trifluoromethylphenyl)- 4-alkyl-1H-[1,2,3]-triazoles.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Ellman's-reagent-mediated regeneration of trypanothione in situ: substrate-economical microplate and time-dependent inhibition assays for trypanothione reductase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Trypanothione reductase from Trypanosoma cruzi. Catalytic properties of the enzyme and inhibition studies with trypanocidal compounds

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfi

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Pentafluorosulfanyl as a novel building block for enzyme inhibitors: trypanothione reductase inhibition and antiprotozoal activities of diarylamines

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

21 January 2018

Charge is the major discriminating factor for glutathione reductase versus trypanothione reductase inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of the Trypanosoma cruzi trypanothione reductase.mepacrine complex

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

7 January 2021

based on heuristic

inferred from DOI database lookup

2-Amino diphenylsulfides as new inhibitors of trypanothione reductase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

7 January 2021

based on heuristic

inferred from DOI database lookup

Cyclodextrin-based bioactive supramolecular assemblies

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

7 January 2021

based on heuristic

inferred from DOI database lookup

New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi Trypanothione Reductase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000420

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/CMDC.201000420

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21275053%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21275053%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q58848500&oldid=2128254952"