(Q42152987)

17 October 2017

Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structures (English)

1 reference

17 October 2017

5

A. H. Fairlamb

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1355650

17 September 2022

author name string

T. J. Benson

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1355650

17 September 2022

J. H. McKie

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1355650

17 September 2022

J. Garforth

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1355650

17 September 2022

A. Borges

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1355650

17 September 2022

K. T. Douglas

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1355650

17 September 2022

language of work or name

English

0 references

publication date

1 August 1992

1 reference

PMC publication ID

1133010

17 October 2017

15 August 1992

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1355650

full work available at URL

17 September 2022

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/1355650/?tool=EBI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1355650

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/1355650/pdf/?tool=EBI

17 September 2022

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1355650

https://europepmc.org/articles/PMC1133010

17 September 2022

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1355650

https://europepmc.org/articles/PMC1133010?pdf=render

17 September 2022

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1355650

17 September 2022

1 reference

17 October 2017

286 ( Pt 1)

1 reference

17 October 2017

9-11

1 reference

Antidepressants cause lethal disruption of membrane function in the human protozoan parasite Leishmania.

17 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133010

Human glutathione reductase: purification of the crystalline enzyme from erythrocytes.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133010

Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133010

Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133010

Refined structure of glutathione reductase at 1.54 A resolution

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133010

Fast purification of a functional elongator tRNAmetexpressed from a synthetic genein vivo

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133010

Redox enzyme engineering: conversion of human glutathione reductase into a trypanothione reductase

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133010

Cloning, sequencing, overproduction and purification of trypanothione reductase from Trypanosoma cruzi.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133010

Mutational analysis of parasite trypanothione reductase: acquisition of glutathione reductase activity in a triple mutant

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133010

Engineering the substrate specificity of glutathione reductase toward that of trypanothione reduction

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133010

X-ray structure of trypanothione reductase from Crithidia fasciculata at 2.4-A resolution

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133010

New enzymes for old: Redesigning the coenzyme and substrate specificities of glutathione reductase

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133010

Trypanocidal action of neuroleptic phenothiazines in Trypanosoma brucei

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133010

An assay for screening drugs against animal-infective bloodstream forms of Trypanosoma brucei brucei in vitro.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133010

Trypanothione reductase from Trypanosoma cruzi. Purification and characterization of the crystalline enzyme.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133010

Trypanosoma cruzi: possible control of parasite transmission by blood transfusion using amphiphilic cationic drugs

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133010

Synthesis of N-benzyloxycarbonyl-l-cysteinylglycine 3-dimethylaminopropylamide disulfide: A cheap and convenient new assay for trypanothione reductase

1 December 2018

1 reference

12 December 2020

Lethal Effect of Phenothiazine Neuroleptics on the Pathogenic ProtozoanLeishmania donovani

1 reference

12 December 2020

A crystallographic study of the glutathione binding site of glutathione reductase at 0.3-nm resolution

1 reference

12 December 2020

Substrate specificity of the flavoprotein trypanothione disulfide reductase from Crithidia fasciculata

1 reference

12 December 2020

Identifiers

DOI

10.1042/BJ2860009

1 reference

17 October 2017

1 reference

PMC publication ID

1133010

17 October 2017

1 reference

PMC publication ID

1133010