(Q43256895)

English

Synthesis, inhibition potency, binding mode, and antiprotozoal activities of fluorescent inhibitors of trypanothione reductase based on mepacrine-conjugated diaryl sulfide scaffolds

scientific article published in December 2009

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

17 November 2017

Synthesis, inhibition potency, binding mode, and antiprotozoal activities of fluorescent inhibitors of trypanothione reductase based on mepacrine-conjugated diaryl sulfide scaffolds (English)

1 reference

Europe PubMed Central

PubMed publication ID

17 November 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

17 November 2017

object named as

Bernhard Stump

3

0 references

François Diederich

7

object named as

François Diederich

1 reference

Europe PubMed Central

PubMed publication ID

17 November 2017

5

object named as

Reto Brun

1 reference

Europe PubMed Central

PubMed publication ID

17 November 2017

author name string

Christian Eberle

1

1 reference

Europe PubMed Central

PubMed publication ID

17 November 2017

Johannes A Burkhard

2

1 reference

Europe PubMed Central

PubMed publication ID

17 November 2017

R Luise Krauth-Siegel

6

1 reference

Europe PubMed Central

PubMed publication ID

17 November 2017

publication date

1 December 2009

1 reference

Europe PubMed Central

PubMed publication ID

17 November 2017

1 reference

Europe PubMed Central

PubMed publication ID

17 November 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

17 November 2017

12

1 reference

Europe PubMed Central

PubMed publication ID

17 November 2017

2034-2044

1 reference

Europe PubMed Central

PubMed publication ID

17 November 2017

Leishmaniasis and poverty

1 reference

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Parasitology. Drugs to combat tropical protozoan parasites

1 reference

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21 January 2018

New drugs for the treatment of human African trypanosomiasis: research and development

1 reference

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Mission possible

1 reference

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Dithiol proteins as guardians of the intracellular redox milieu in parasites: old and new drug targets in trypanosomes and malaria-causing plasmodia

1 reference

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21 January 2018

Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids

1 reference

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21 January 2018

Parasite-specific trypanothione reductase as a drug target molecule

1 reference

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21 January 2018

Target assessment for antiparasitic drug discovery

1 reference

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Picking pockets to fuel antimicrobial drug discovery

1 reference

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Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis

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Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase

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Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structures

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Use of an additional hydrophobic binding site, the Z site, in the rational drug design of a new class of stronger trypanothione reductase inhibitor, quaternary alkylammonium phenothiazines

1 reference

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21 January 2018

Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfi

1 reference

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21 January 2018

Diaryl sulfide-based inhibitors of trypanothione reductase: inhibition potency, revised binding mode and antiprotozoal activities

1 reference

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21 January 2018

Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors

1 reference

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21 January 2018

MAB, a generally applicable molecular force field for structure modelling in medicinal chemistry.

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Synthesis and in vitro evaluation of novel morpholinyl- and methylpiperazinylacyloxyalkyl prodrugs of 2-(6-methoxy-2-naphthyl)propionic acid (Naproxen) for topical drug delivery

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2,3-Dihydro-2-oxo-1H-benzimidazole-1-carboxamides with selective affinity for the 5-HT(4) receptor: synthesis and structure-affinity and structure-activity relationships of a new series of partial agonist and antagonist derivatives

1 reference

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"Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease

1 reference

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21 January 2018

Betraying the parasite's redox system: diaryl sulfide-based inhibitors of trypanothione reductase: subversive substrates and antitrypanosomal properties

1 reference

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21 January 2018

Accumulation and intracellular distribution of antitrypanosomal diamidine compounds DB75 and DB820 in African trypanosomes

1 reference

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21 January 2018

Transporters in African trypanosomes: role in drug action and resistance

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Uptake of diamidine drugs by the P2 nucleoside transporter in melarsen-sensitive and -resistant Trypanosoma brucei brucei

1 reference

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21 January 2018

Interaction energies of nitrofurans with trypanothione reductase and glutathione reductase studied by molecular docking

1 reference

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21 January 2018

Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs

1 reference

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21 January 2018

Crystal structure of the Trypanosoma cruzi trypanothione reductase.mepacrine complex

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

2-Amino diphenylsulfides as new inhibitors of trypanothione reductase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900327

7 January 2021

based on heuristic

inferred from DOI database lookup

New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi Trypanothione Reductase

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

2-Amino diphenylsulfides as inhibitors of trypanothione reductase: modification of the side chain

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900327

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of Trypanosoma cruzi trypanothione reductase by acridines: kinetic studies and structure-activity relationships

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900327

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanism of reduction of quinones by Trypanosoma congolense trypanothione reductase

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/CMDC.200900327

1 reference

Europe PubMed Central

PubMed publication ID

17 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 November 2017

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