(Q33474992)

27 July 2017

title

Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis (English)

1 reference

27 July 2017

Ian H Gilbert

5

0 references

Alan Fairlamb

object named as

Alan H Fairlamb

6

0 references

Deuan C Jones

3

object named as

Deuan C Jones

1 reference

27 July 2017

John L Richardson

1

1 reference

27 July 2017

Isabelle R E Nett

2

1 reference

27 July 2017

Mohamed H Abdille

4

1 reference

27 July 2017

publication date

1 August 2009

1 reference

27 July 2017

1 reference

27 July 2017

volume

4

1 reference

27 July 2017

issue

8

1 reference

27 July 2017

page(s)

1333-1340

1 reference

Enzymatic inhibitory activity and trypanocidal effects of extracts and compounds from Siphoneugena densiflora O. Berg and Vitex polygama Cham

27 July 2017

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Kinetoplastids: related protozoan pathogens, different diseases

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Betraying the parasite's redox system: diaryl sulfide-based inhibitors of trypanothione reductase: subversive substrates and antitrypanosomal properties

14 July 2018

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Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro

14 July 2018

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High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity

14 July 2018

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Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening

14 July 2018

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Drug resistance in leishmaniasis

14 July 2018

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Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfi

14 July 2018

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Time-dependent inhibitors of trypanothione reductase: analogues of the spermidine alkaloid lunarine and related natural products

14 July 2018

1 reference

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Mechanism and structure-activity relationships of norspermidine-based peptidic inhibitors of trypanothione reductase

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929371

Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani

14 July 2018

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Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug design

14 July 2018

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Enzymes of the trypanothione metabolism as targets for antitrypanosomal drug development

14 July 2018

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Ebselen: a substrate for human thioredoxin reductase strongly stimulating its hydroperoxide reductase activity and a superfast thioredoxin oxidant

14 July 2018

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Potent and specific inhibitors of trypanothione reductase from Trypanosoma cruzi: bis(2-aminodiphenylsulfides) for fluorescent labeling studies

14 July 2018

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

14 July 2018

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Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents

14 July 2018

1 reference

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2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.

14 July 2018

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Trypanothione reductase inhibition/trypanocidal activity relationships in a 1,4-bis(3-aminopropyl)piperazine series

14 July 2018

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Use of an additional hydrophobic binding site, the Z site, in the rational drug design of a new class of stronger trypanothione reductase inhibitor, quaternary alkylammonium phenothiazines

14 July 2018

1 reference

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Antimalarial, antitrypanosomal, and antileishmanial activities and cytotoxicity of bis(9-amino-6-chloro-2-methoxyacridines): influence of the linker

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929371

Synthesis and evaluation of 9,9-dimethylxanthene tricyclics against trypanothione reductase, Trypanosoma brucei, Trypanosoma cruzi and Leishmania donovani

14 July 2018

1 reference

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Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress

14 July 2018

1 reference

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Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors

14 July 2018

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Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survival

14 July 2018

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Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.

14 July 2018

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Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909).

14 July 2018

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Synthesis and psychoanaleptic properties of new compounds structurally related to diphenhydramine

14 July 2018

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Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids

14 July 2018

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Trypanothione is the primary target for arsenical drugs against African trypanosomes

14 July 2018

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14 July 2018

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Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers

14 July 2018

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Molecular characterization of the trypanothione reductase gene from Crithidia fasciculata and Trypanosoma brucei: comparison with other flavoprotein disulphide oxidoreductases with respect to substrate specificity and catalytic mechanism

14 July 2018

1 reference

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Metabolism and functions of trypanothione in the Kinetoplastida

14 July 2018

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Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structures

14 July 2018

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Effects of clomipramine on Trypanosoma cruzi infection in mice

14 July 2018

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Peptoid inhibition of trypanothione reductase as a potential antitrypanosomal and antileishmanial drug lead

21 January 2018

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Ellman's-reagent-mediated regeneration of trypanothione in situ: substrate-economical microplate and time-dependent inhibition assays for trypanothione reductase

21 January 2018

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Synthesis of dihydronaphthofurandiones and dihydrofuroquinolinediones with trypanocidal activity and analysis of their stereoelectronic properties

21 January 2018

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Inhibitors of Trypanosoma cruzi trypanothione reductase revealed by virtual screening and parallel synthesis

21 January 2018

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A scoring scheme for discriminating between drugs and nondrugs.

21 January 2018

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Drug cytotoxicity assay for African trypanosomes and Leishmania species

21 January 2018

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8-Methoxy-naphtho[2,3-b]thiophen-4,9-quinone, a non-competitive inhibitor of trypanothione reductase

21 January 2018

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7 January 2021

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In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei

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Substrate specificity of the flavoprotein trypanothione disulfide reductase from Crithidia fasciculata

21 January 2018

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Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs

21 January 2018

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21 January 2018

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Novel antitrypanosomal agents based on palladium nitrofurylthiosemicarbazone complexes: DNA and redox metabolism as potential therapeutic targets

10 December 2018

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21 January 2018

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Inhibition of trypanothione reductase and glutathione reductase by ferrocenic 4-aminoquinoline ureas

10 December 2018

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2-Amino diphenylsulfides as inhibitors of trypanothione reductase: modification of the side chain

21 January 2018

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Inhibition of Trypanosoma cruzi trypanothione reductase by crystal violet

10 December 2018

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12 December 2020

Chinifur, a selective inhibitor and "subversive substrate" for Trypanosoma congolense trypanothione reductase

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12 December 2020

Charge is the major discriminating factor for glutathione reductase versus trypanothione reductase inhibitors

1 reference

12 December 2020

New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi Trypanothione Reductase

1 reference

12 December 2020

Polyamine derivatives as inhibitors of trypanothione reductase and assessment of their trypanocidal activities

1 reference

12 December 2020

Structure-activity relationships in 2-aminodiphenylsulfides against trypanothione reductase from Trypanosoma cruzi

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12 December 2020

Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity

1 reference

12 December 2020

Inhibition of Trypanosoma cruzi trypanothione reductase by acridines: kinetic studies and structure-activity relationships

1 reference

12 December 2020

New potent inhibitors of trypanothione reductase from Trypanosoma cruzi in the 2-aminodiphenylsulfide series

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7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1002/CMDC.200900097

1 reference

27 July 2017

1 reference

27 July 2017

1 reference