(Q44560961)

4 December 2017

title

8-Methoxy-naphtho[2,3-b]thiophen-4,9-quinone, a non-competitive inhibitor of trypanothione reductase (English)

1 reference

4 December 2017

Alan H Fairlamb

2

0 references

author name string

Carlos L Zani

series ordinal

1

1 reference

4 December 2017

Alan H Fairlamb

series ordinal

2

1 reference

4 December 2017

publication date

1 June 2003

1 reference

Memórias do Instituto Oswaldo Cruz

4 December 2017

June 2003

0 references

published in

1 reference

4 December 2017

volume

98

1 reference

4 December 2017

issue

4

1 reference

4 December 2017

page(s)

565-568

1 reference

Diamine auxotrophy may be a universal feature of Trypanosoma cruzi epimastigotes

4 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762003000400026

Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762003000400026

Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762003000400026

Site-directed mutagenesis of the redox-active cysteines of Trypanosoma cruzi trypanothione reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762003000400026

Trypanothione Reductase from Leishmania donovani. Purification, Characterisation and Inhibition by Trivalent Antimonials

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762003000400026

Metabolism and functions of trypanothione in the Kinetoplastida

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762003000400026

Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762003000400026

Glutathione and trypanothione in parasitic hydroperoxide metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762003000400026

Trypanocidal Bisbenzylisoquinoline Alkaloids are Inhibitors of Trypanothione Reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762003000400026

Efficacy of the bisbenzylisoquinoline alkaloids in acute and chronic Trypanosoma cruzi murine model

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762003000400026

Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: crystallographic, kinetic, and spectroscopic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762003000400026

Ellman's-reagent-mediated regeneration of trypanothione in situ: substrate-economical microplate and time-dependent inhibition assays for trypanothione reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762003000400026

"Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762003000400026

Docking and molecular dynamics studies at trypanothione reductase and glutathione reductase active sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762003000400026

Trypanothione reductase from Trypanosoma cruzi. Catalytic properties of the enzyme and inhibition studies with trypanocidal compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762003000400026

Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762003000400026

Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762003000400026

2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762003000400026

Parallel synthesis of a library of 1,4-naphthoquinones and automated screening of potential inhibitors of trypanothione reductase from Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762003000400026

Enzymes of the trypanothione metabolism as targets for antitrypanosomal drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762003000400026

Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762003000400026

Target-based drug discovery for malaria, leishmaniasis, and trypanosomiasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762003000400026

Human glutathione reductase: purification of the crystalline enzyme from erythrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762003000400026

Anti-plasmodial and anti-trypanosomal activity of synthetic naphtho[2,3-b]thiopen-4,9-quinones

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0074-02762003000400026

10.1590/S0074-02762003000400026

21 January 2018

Identifiers

DOI

0 references

1 reference