(Q34007340)

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Betraying the parasite's redox system: diaryl sulfide-based inhibitors of trypanothione reductase: subversive substrates and antitrypanosomal properties

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Europe PubMed Central

PubMed publication ID

30 July 2017

Betraying the parasite's redox system: diaryl sulfide-based inhibitors of trypanothione reductase: subversive substrates and antitrypanosomal properties (English)

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Europe PubMed Central

PubMed publication ID

30 July 2017

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Europe PubMed Central

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30 July 2017

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Bernhard Stump

1

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François Diederich

5

object named as

François Diederich

1 reference

Europe PubMed Central

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30 July 2017

3

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Reto Brun

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30 July 2017

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R Luise Krauth-Siegel

4

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30 July 2017

publication date

1 December 2007

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30 July 2017

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Europe PubMed Central

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30 July 2017

2

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30 July 2017

12

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Europe PubMed Central

PubMed publication ID

30 July 2017

1708-1712

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Europe PubMed Central

PubMed publication ID

30 July 2017

Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structures

1 reference

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Strategic emphases for tropical diseases research: a TDR perspective.

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Chemotherapy of human African trypanosomiasis

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Metabolism and functions of trypanothione in the Kinetoplastida

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The therapeutic potential of inhibitors of the trypanothione cycle

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Trypanothione reductase from Trypanosoma cruzi. Catalytic properties of the enzyme and inhibition studies with trypanocidal compounds

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An approach to the development of new drugs for African trypanosomiasis

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Generation of superoxide anion and hydrogen peroxide induced by nifurtimox in Trypanosoma cruzi

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Nitrofuran drugs as common subversive substrates of Trypanosoma cruzi lipoamide dehydrogenase and trypanothione reductase

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Chinifur, a selective inhibitor and "subversive substrate" for Trypanosoma congolense trypanothione reductase

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2-Amino diphenylsulfides as new inhibitors of trypanothione reductase

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Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfi

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Synthesis of N-benzyloxycarbonyl-l-cysteinylglycine 3-dimethylaminopropylamide disulfide: A cheap and convenient new assay for trypanothione reductase

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Kinetics and crystallographic analysis of human glutathione reductase in complex with a xanthene inhibitor

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2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.

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MAB, a generally applicable molecular force field for structure modelling in medicinal chemistry.

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Superoxide dismutase: a comparison of rate constants.

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Interactions of nitroaromatic compounds with the mammalian selenoprotein thioredoxin reductase and the relation to induction of apoptosis in human cancer cells

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Identifiers

10.1002/CMDC.200700172

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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