(Q34519134)

2 August 2017

1 reference

title

The therapeutic potential of inhibitors of the trypanothione cycle (English)

1 reference

2 August 2017

Claudius D'Silva

1

1 reference

2 August 2017

Sylvie Daunes

series ordinal

2

1 reference

2 August 2017

language of work or name

English

0 references

publication date

1 February 2002

1 reference

Expert Opinion on Investigational Drugs

2 August 2017

1 reference

2 August 2017

11

1 reference

2 August 2017

2

1 reference

2 August 2017

217-231

1 reference

The biochemical basis of arsenical-diamidine crossresistance in African trypanosomes

2 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Placebo-Controlled Clinical Trial of Sodium Stibogluconate (Pentostam) versus Ketoconazole for Treating Cutaneous Leishmaniasis in Guatemala

21 January 2018

1 reference

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The challenge of Chagas' disease chemotherapy: an update of drugs assayed against Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Amphotericin B: new life for an old drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Topical treatment of Old World cutaneous leishmaniasis caused by Leishmania major: A double-blind control study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Practical progress and new drugs for changing patterns of leishmaniasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Heteroatom-substituted fatty acid analogs as substrates for N-myristoyltransferase: an approach for studying both the enzymology and function of protein acylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

An analog of myristic acid with selective toxicity for African trypanosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Ribonucleotide reductase: A new target for antiparasite therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Enzymes of parasite thiol metabolism as drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Cloning, sequencing, and demonstration of polymorphism in trypanothione reductase from Crithidia fasciculata

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Trypanothione reductase of Trypanosoma congolense: gene isolation, primary sequence determination, and comparison to glutathione reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Cloning, sequencing, overproduction and purification of trypanothione reductase from Trypanosoma cruzi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Substrate interactions between trypanothione reductase and N1-glutathionylspermidine disulphide at 0.28-nm resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Comparison of resin and solution screening methodologies in combinatorial chemistry and the identification of a 100 nM inhibitor of trypanothione reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Interaction of AZA analogs of chlorpromazine with the dopamine D2 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Potent and specific inhibitors of trypanothione reductase from Trypanosoma cruzi: bis(2-aminodiphenylsulfides) for fluorescent labeling studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

"Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: crystallographic, kinetic, and spectroscopic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Trypanosoma brucei tryparedoxin, a thioredoxin-like protein in African trypanosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Subcellular distribution of trypanothione reductase in bloodstream and procyclic forms of Trypanosoma brucei.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Molecular characterisation of mitochondrial and cytosolic trypanothione-dependent tryparedoxin peroxidases in Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

The high resolution crystal structure of recombinant Crithidia fasciculata tryparedoxin-I

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Photo-labelling of glutaredoxin from Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Role of the N-terminus of glutathione in the action of yeast glyoxalase I

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

QSAR study on the contribution of log P and E(s) to the in vitro antiprotozoal activity of glutathione derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Glutathione derivatives active against Trypanosoma brucei rhodesiense and T. brucei brucei in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

The Organosulfur Chemistry of the GenusAllium - Implications for the Organic Chemistry of Sulfur

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Anti-sleeping Sickness Drugs and Cancer Chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Substrate specificity of the flavoprotein trypanothione disulfide reductase from Crithidia fasciculata

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Synthesis of N-benzyloxycarbonyl-l-cysteinylglycine 3-dimethylaminopropylamide disulfide: A cheap and convenient new assay for trypanothione reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

Bimane cyclic esters, possible stereologues of trypanothione as antitrypanosomal agents. Bimanes 29

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.2.217

10.1517/13543784.11.2.217

21 January 2018

Identifiers

DOI

1 reference

release_m4px53nhbzc3fo7azu5v3t3a54

2 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/m4px53nhbzc3fo7azu5v3t3a54

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference