(Q74154992)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9459012%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

title

Polyamine derivatives as inhibitors of trypanothione reductase and assessment of their trypanocidal activities (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9459012%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

author name string

M C O'Sullivan

1

1 reference

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9 November 2019

Q Zhou

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9459012%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Z Li

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9459012%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

T B Durham

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9459012%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

D Rattendi

5

1 reference

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9 November 2019

S Lane

6

1 reference

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9 November 2019

C J Bacchi

7

1 reference

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9 November 2019

language of work or name

English

0 references

publication date

1 December 1997

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9459012%20AND%20SRC:MED&resulttype=core&format=json

Bioorganic & Medicinal Chemistry

9 November 2019

published in

1 reference

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9 November 2019

volume

5

1 reference

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9 November 2019

issue

12

1 reference

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9 November 2019

page(s)

2145-2155

1 reference

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Trypanothione metabolism: a chemotherapeutic target in trypanosomatids

9 November 2019

cites work

1 reference

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7 January 2021

Future prospects for the chemotherapy of human trypanosomiasis. 1. Novel approaches to the chemotherapy of trypanosomiasis

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7 January 2021

Trypanothione metabolism and rational approaches to drug design

1 reference

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7 January 2021

Molecular studies on trypanothione reductase: an antiparasitic target enzyme

1 reference

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7 January 2021

Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids

1 reference

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7 January 2021

Simple methods for the detection and quantification of thiols from Crithidia fasciculata and for the isolation of trypanothione

1 reference

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7 January 2021

Identification of a novel, thiol-containing co-factor essential for glutathione reductase enzyme activity in trypanosomatids.

1 reference

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7 January 2021

The treatment of human African trypanosomiasis

1 reference

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7 January 2021

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7 January 2021

Metabolism and functions of trypanothione in the Kinetoplastida

1 reference

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7 January 2021

Purification and characterization of a trypanothione-glutathione thioltransferase from Trypanosoma cruzi

1 reference

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7 January 2021

Substrate specificity of the flavoprotein trypanothione disulfide reductase from Crithidia fasciculata

1 reference

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7 January 2021

Flavoprotein structure and mechanism. 5. Trypanothione reductase and lipoamide dehydrogenase as targets for a structure-based drug design.

1 reference

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7 January 2021

Disulfide-Reductase Inhibitors as Chemotherapeutic Agents: The Design of Drugs for Trypanosomiasis and Malaria

1 reference

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7 January 2021

Trypanothione reductase from Trypanosoma cruzi. Catalytic properties of the enzyme and inhibition studies with trypanocidal compounds

1 reference

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7 January 2021

Synthesis of N-benzyloxycarbonyl-l-cysteinylglycine 3-dimethylaminopropylamide disulfide: A cheap and convenient new assay for trypanothione reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2897%2900157-0

7 January 2021

Rational design of peptide-based inhibitors of trypanothione reductase as potential antitrypanosomal drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2897%2900157-0

7 January 2021

Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2897%2900157-0

7 January 2021

Compared recognition of di- and trisulfide substrates by glutathione and trypanothione reductases

1 reference

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7 January 2021

Inhibition of Trypanosoma cruzi trypanothione reductase by crystal violet

1 reference

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7 January 2021

Chinifur, a selective inhibitor and "subversive substrate" for Trypanosoma congolense trypanothione reductase

1 reference

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7 January 2021

Fluphenazine photoaffinity labelling of binding sites for phenothiazine inhibitors of trypanothione reductase

1 reference

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7 January 2021

Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structures

1 reference

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7 January 2021

Inhibiting effects of spermidine derivatives on Trypanosoma cruzi trypanothione reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2897%2900157-0

7 January 2021

2-Amino diphenylsulfides as inhibitors of trypanothione reductase: modification of the side chain

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2897%2900157-0

7 January 2021

Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2897%2900157-0

7 January 2021

Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2897%2900157-0

7 January 2021

Expression of Trypanosoma congolense trypanothione reductase in Escherichia coli: overproduction, purification, and characterization

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2897%2900157-0

7 January 2021

Cloning, sequencing, overproduction and purification of trypanothione reductase from Trypanosoma cruzi.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2897%2900157-0

7 January 2021

Crystal structure of the Trypanosoma cruzi trypanothione reductase.mepacrine complex

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2897%2900157-0

7 January 2021

Mutational analysis of parasite trypanothione reductase: acquisition of glutathione reductase activity in a triple mutant

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2897%2900157-0

7 January 2021

Charge is the major discriminating factor for glutathione reductase versus trypanothione reductase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2897%2900157-0

7 January 2021

Regulation of a high-affinity diamine transport system in Trypanosoma cruzi epimastigotes

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2897%2900157-0

7 January 2021

Putrescine active uptake system in the Trypanosomatid Crithidia fasciculata.

1 reference

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7 January 2021

Resistance to DL-alpha-difluoromethylornithine by clinical isolates of Trypanosoma brucei rhodesiense. Role of S-adenosylmethionine

1 reference

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7 January 2021

Substrate interactions between trypanothione reductase and N1-glutathionylspermidine disulphide at 0.28-nm resolution

1 reference

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7 January 2021

10.1016/S0968-0896(97)00157-0

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9459012%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

1 reference