(Q35112639)

6 August 2017

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title

Parasite-specific trypanothione reductase as a drug target molecule (English)

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6 August 2017

author name string

R Luise Krauth-Siegel

series ordinal

1

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6 August 2017

Oliver Inhoff

series ordinal

2

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6 August 2017

publication date

23 April 2003

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6 August 2017

published in

Parasitology Research

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6 August 2017

volume

90 Suppl 2

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6 August 2017

page(s)

S77-85

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(2,2':6',2"-Terpyridine)platinum(II) complexes are irreversible inhibitors of Trypanosoma cruzi trypanothione reductase but not of human glutathione reductase

6 August 2017

cites work

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12 December 2020

Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus

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12 December 2020

A virtual screening approach applied to the search for trypanothione reductase inhibitors.

1 reference

12 December 2020

Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survival

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12 December 2020

Cytotoxicity of (2,2':6',2''-terpyridine)platinum(II) complexes to Leishmania donovani, Trypanosoma cruzi, and Trypanosoma brucei

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12 December 2020

Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structures

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12 December 2020

The behavior and significance of slow-binding enzyme inhibitors

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12 December 2020

Charge is the major discriminating factor for glutathione reductase versus trypanothione reductase inhibitors

1 reference

12 December 2020

Polyamine derivatives as inhibitors of trypanothione reductase and assessment of their trypanocidal activities

1 reference

12 December 2020

Specific peptide inhibitors of trypanothione reductase with backbone structures unrelated to that of substrate: potential rational drug design lead frameworks

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12 December 2020

Trypanothione reductase from Trypanosoma cruzi. Catalytic properties of the enzyme and inhibition studies with trypanocidal compounds

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12 December 2020

Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase.

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12 December 2020

Metabolism and functions of trypanothione in the Kinetoplastida

1 reference

12 December 2020

Use of an additional hydrophobic binding site, the Z site, in the rational drug design of a new class of stronger trypanothione reductase inhibitor, quaternary alkylammonium phenothiazines

1 reference

12 December 2020

"Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease

1 reference

12 December 2020

Nitrofuran drugs as common subversive substrates of Trypanosoma cruzi lipoamide dehydrogenase and trypanothione reductase

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12 December 2020

Effects of clomipramine on Trypanosoma cruzi infection in mice

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12 December 2020

Efficacy of the bisbenzylisoquinoline alkaloids in acute and chronic Trypanosoma cruzi murine model

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12 December 2020

New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi Trypanothione Reductase

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12 December 2020

Coupling of a competitive and an irreversible ligand generates mixed type inhibitors of Trypanosoma cruzi trypanothione reductase

1 reference

12 December 2020

Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors

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12 December 2020

Enzymes of parasite thiol metabolism as drug targets

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12 December 2020

Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress

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12 December 2020

Rational design of selective ligands for trypanothione reductase fromtrypanosoma cruzStructural effects on the inhibition by dibenzazepines based on imipramine

1 reference

12 December 2020

Comparison of resin and solution screening methodologies in combinatorial chemistry and the identification of a 100 nM inhibitor of trypanothione reductase

1 reference

12 December 2020

Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine

1 reference

12 December 2020

Rational drug design using trypanothione reductase as a target for anti-trypanosomal and anti-leishmanial drug leads

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12 December 2020

Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs

1 reference

12 December 2020

Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: crystallographic, kinetic, and spectroscopic studies

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12 December 2020

Chinifur, a selective inhibitor and "subversive substrate" for Trypanosoma congolense trypanothione reductase

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12 December 2020

Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.

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12 December 2020

Inhibition of Trypanosoma cruzi trypanothione reductase by crystal violet

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12 December 2020

Activity and structure relationship of acridine derivatives against African trypanosomes

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12 December 2020

Trypanocidal Bisbenzylisoquinoline Alkaloids are Inhibitors of Trypanothione Reductase

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12 December 2020

The therapeutic potential of inhibitors of the trypanothione cycle

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12 December 2020

Enzymes of the trypanothione metabolism as targets for antitrypanosomal drug development

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12 December 2020

Mechanism of reduction of quinones by Trypanosoma congolense trypanothione reductase

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12 December 2020

Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents

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12 December 2020

Optimising inhibitors of trypanothione reductase using solid-phase chemistry

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12 December 2020

2-Amino diphenylsulfides as new inhibitors of trypanothione reductase

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12 December 2020

2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.

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12 December 2020

Crystal structure of the Trypanosoma cruzi trypanothione reductase.mepacrine complex

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12 December 2020

Trypanosoma cruzi trypanothione reductase is inactivated by peroxidase-generated phenothiazine cationic radicals

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12 December 2020

A novel series of chemical structures active in vitro against the trypomastigote form of Trypanosoma cruzi

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12 December 2020

Inhibition of trypanothione reductase by substrate analogues

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12 December 2020

Inhibition of Trypanosoma cruzi trypanothione reductase by acridines: kinetic studies and structure-activity relationships

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12 December 2020

Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents

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12 December 2020

Potent and specific inhibitors of trypanothione reductase from Trypanosoma cruzi: bis(2-aminodiphenylsulfides) for fluorescent labeling studies

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12 December 2020

10.1007/S00436-002-0771-8

Identifiers

DOI

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6 August 2017

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