(Q42094447)

16 October 2017

Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata (English)

1 reference

16 October 2017

Crithidia fasciculata

object named as

Crithidia fasciculata

1 reference

Sandra L Oza

1

0 references

Alan Fairlamb

object named as

Alan H Fairlamb

series ordinal

3

0 references

Mark R Ariyanayagam

series ordinal

2

object named as

Mark R Ariyanayagam

1 reference

16 October 2017

PMC publication ID

1222616

language of work or name

English

0 references

publication date

1 June 2002

1 reference

16 October 2017

1 reference

16 October 2017

364

1 reference

16 October 2017

Pt 3

1 reference

16 October 2017

679-686

1 reference

Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents

16 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222616

Target-based drug discovery for malaria, leishmaniasis, and trypanosomiasis

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222616

Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222616

Future prospects for the chemotherapy of Chagas' disease

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222616

Glutathione and trypanothione in parasitic hydroperoxide metabolism

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222616

Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222616

Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survival

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222616

A structure-based approach to drug discovery; crystallography and implications for the development of antiparasite drugs.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222616

Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222616

Glutathionylspermidine metabolism in Escherichia coli.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222616

A self-consistent method for the analysis of protein secondary structure from circular dichroism.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222616

Glutathionylspermidine metabolism in Escherichia coli. Purification, cloning, overproduction, and characterization of a bifunctional glutathionylspermidine synthetase/amidase

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222616

Site-directed mutagenesis of the redox-active cysteines of Trypanosoma cruzi trypanothione reductase.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222616

Flavoprotein structure and mechanism. 5. Trypanothione reductase and lipoamide dehydrogenase as targets for a structure-based drug design.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222616

Efficient amplification using 'megaprimer' by asymmetric polymerase chain reaction

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222616

Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222616

Levels of polyamines, glutathione and glutathione-spermidine conjugates during growth of the insect trypanosomatid Crithidia fasciculata.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222616

Biosynthesis of the trypanosomatid metabolite trypanothione: purification and characterization of trypanothione synthetase from Crithidia fasciculata

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222616

Metabolism and functions of trypanothione in the Kinetoplastida

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222616

Purification of glutathionylspermidine and trypanothione synthetases from Crithidia fasciculata

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222616

Identification of a novel, thiol-containing co-factor essential for glutathione reductase enzyme activity in trypanosomatids.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222616

Ovothiol and trypanothione as antioxidants in trypanosomatids

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222616

Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222616

Drug development output from 1975 to 1996: what proportion for tropical diseases?

17 August 2018

1 reference

12 December 2020

Isolation, characterization, and turnover of glutathionylspermidine from Escherichia coli

1 reference

12 December 2020

Dissection of glutathionylspermidine synthetase/amidase from Escherichia coli into autonomously folding and functional synthetase and amidase domains

1 reference

12 December 2020

Characterization of the peptide substrate specificity of glutathionylspermidine synthetase from Crithidia fasciculata

1 reference

12 December 2020

Convenient isolation and kinetic mechanism of glutathionylspermidine synthetase from Crithidia fasciculata

1 reference

12 December 2020

Evidence for a glutathionyl-enzyme intermediate in the amidase activity of the bifunctional glutathionylspermidine synthetase/amidase from Escherichia coli

1 reference

12 December 2020

Identifiers

DOI

10.1042/BJ20011370

1 reference

16 October 2017

1 reference

PMC publication ID

1222616

16 October 2017

PubMed publication ID

12049631

1 reference

PMC publication ID

1222616