(Q42099426)

16 October 2017

DNA damage measured by the comet assay in head and neck cancer patients treated with tirapazamine (English)

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16 October 2017

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head and neck carcinoma

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M J Dorie

1

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16 October 2017

M S Kovacs

2

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16 October 2017

E C Gabalski

3

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16 October 2017

M Adam

4

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16 October 2017

Q T Le

5

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16 October 2017

D A Bloch

6

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16 October 2017

H A Pinto

7

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16 October 2017

D J Terris

8

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16 October 2017

J M Brown

9

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16 October 2017

1 November 1999

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16 October 2017

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16 October 2017

1

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16 October 2017

461-467

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16 October 2017

5

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describes a project that uses

16 October 2017

1 reference

Cisplatin anti-tumour potentiation by tirapazamine results from a hypoxia-dependent cellular sensitization to cisplatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1508108

Tissue oxygen distribution in head and neck cancer patients

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1508108

Tirapazamine: laboratory data relevant to clinical activity.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1508108

Tirapazamine-induced cytotoxicity and DNA damage in transplanted tumors: relationship to tumor hypoxia.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1508108

Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1508108

Cells at intermediate oxygen levels can be more important than the "hypoxic fraction" in determining tumor response to fractionated radiotherapy

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1508108

Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a phase I trial

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1508108

Tirapazamine-induced DNA damage measured using the comet assay correlates with cytotoxicity towards hypoxic tumour cells in vitro

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1508108

SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1508108

Unusual oxygen concentration dependence of toxicity of SR-4233, a hypoxic cell toxin.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1508108

A new mouse tumor model system (RIF-1) for comparison of end-point studies

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1508108

Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1508108

SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1508108

Detection of etoposide resistance by measuring DNA damage in individual Chinese hamster cells

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1508108

Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet" assay

29 May 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1508108

29 May 2018

https://api.crossref.org/works/10.1038%2FSJ.NEO.7900060

7 January 2021

inferred from DOI database lookup

Potentiation by the hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1508108

Therapeutic advantage of hypoxic cells in tumors: a theoretical study

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1508108

Factors influencing DNA migration from individual cells subjected to gel electrophoresis

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1508108

Oxygen tension measurements of tumors growing in mice.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1508108

Tirapazamine is metabolized to its DNA-damaging radical by intranuclear enzymes.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1508108

Stable translocations detected by fluorescence in situ hybridization: a rapid surrogate end point to evaluate the efficacy of a potentiator of tumor response to radiotherapy.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1508108

Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatin.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1508108

Oxygen tension measurements of head and neck cancers.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1508108

Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck

17 August 2018

1 reference

12 December 2020

Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy

1 reference

12 December 2020

Concurrent tirapazamine and radiotherapy for advanced head and neck carcinomas: a Phase II study

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12 December 2020

SR 4233: a tumor specific radiosensitizer active in fractionated radiation regimes

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12 December 2020

Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma

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12 December 2020

Detection of DNA-crosslinking agents with the alkaline comet assay

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12 December 2020

Tumor hypoxia can be exploited to preferentially sensitize tumors to fractionated irradiation

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12 December 2020

Measuring DNA damage in individual cells of heterogeneous mixtures: a novel application of an immunological typing technique

1 reference

12 December 2020

The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy

1 reference

12 December 2020

Oxygenation of head and neck tumors

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12 December 2020

Use of the comet assay to identify cells sensitive to tirapazamine in multicell spheroids and tumors in mice

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12 December 2020

Effect of partition coefficient on the ability of nitroimidazoles to enhance the cytotoxicity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea

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12 December 2020

Reoxygenation and rehypoxiation in the SCCVII mouse tumor

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12 December 2020

Physiologic and cytotoxic effects of tirapazamine in tumor-bearing mice

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12 December 2020

Measurement of Human Tumour Oxygenation Status by a Polarographic Needle Electrode: An analysis of inter- and intratumour heterogeneity

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12 December 2020

Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix

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12 December 2020

Identifiers

DOI

10.1038/SJ.NEO.7900060

1 reference

16 October 2017

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16 October 2017

1 reference