(Q42121954)

16 October 2017

Oligobenzamide proteomimetic inhibitors of the p53-hDM2 protein-protein interaction (English)

1 reference

Design and Synthesis of Functional Aromatic Oligoamide Foldamers

16 October 2017

1 reference

Gateway to Research Project ID

Gateway to Research

EP/D077842/1

protein-protein interaction

27 April 2019

main subject

1 reference

5

1 reference

16 October 2017

7

Andrew J Wilson

0 references

Thomas A Edwards

6

Thomas A Edwards

0 references

Michael E. Webb

Michael E Webb

4

0 references

Jeffrey P Plante

Jeffrey P Plante

1

0 references

Barbora Malkova

3

Barbora Malkova

1 reference

16 October 2017

Thomas Burnley

2

1 reference

PMCID

2898631

16 October 2017

language of work or name

English

0 references

publication date

24 June 2009

1 reference

16 October 2017

Chemical Communications

1 reference

16 October 2017

34

1 reference

16 October 2017

5091-5093

1 reference

Beta-peptides with improved affinity for hDM2 and hDMX.

16 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898631

Synthesis and biological evaluation of a 5-6-5 imidazole-phenyl-thiazole based alpha-helix mimetic

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898631

alpha-Helix mimetics as inhibitors of protein-protein interactions

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898631

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898631

Heterocyclic alpha-helix mimetics for targeting protein-protein interactions

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898631

Shape-persistent aromatic amide oligomers: new tools for supramolecular chemistry

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898631

p53--a natural cancer killer: structural insights and therapeutic concepts

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898631

Inhibiting HIV fusion with a beta-peptide foldamer

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898631

Terphenyl-Based Bak BH3 alpha-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898631

Strategies for targeting protein-protein interactions with synthetic agents.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898631

Terephthalamide derivatives as mimetics of helical peptides: disruption of the Bcl-x(L)/Bak interaction

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898631

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898631

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898631

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898631

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898631

Synthetic inhibitors of extended helix-protein interactions based on a biphenyl 4,4'-dicarboxamide scaffold

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898631

Controlling curvature in a family of oligoamide alpha-helix mimetics.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898631

Synthesis of functionalised aromatic oligamide rods

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898631

Benzoylurea oligomers: synthetic foldamers that mimic extended alpha helices

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898631

Macrocyclic scaffolds derived from p-aminobenzoic acid.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898631

Recognition of solvent exposed protein surfaces using anthracene derived receptors.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898631

Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898631

Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898631

Helical beta-peptide inhibitors of the p53-hDM2 interaction.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898631

Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898631

Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an alpha-helix

17 August 2018

1 reference

12 December 2020

Protein−Protein Interactions: Interface Structure, Binding Thermodynamics, and Mutational Analysis

1 reference

12 December 2020

Small-molecule inhibitors of the p53-HDM2 interaction for the treatment of cancer

1 reference

12 December 2020

Synthesis and structure of 1,4-dipiperazino benzenes: chiral terphenyl-type peptide helix mimetics

1 reference

12 December 2020

Helix mimetics as inhibitors of the interaction of the estrogen receptor with coactivator peptides

1 reference

12 December 2020

(alpha/beta+alpha)-peptide antagonists of BH3 domain/Bcl-x(L) recognition: toward general strategies for foldamer-based inhibition of protein-protein interactions

1 reference

12 December 2020

Identifiers

DOI

10.1039/B908207G

1 reference

16 October 2017

0 references

1 reference

16 October 2017

1 reference

PMCID

2898631