(Q42166594)

17 October 2017

title

Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling (English)

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17 October 2017

5

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17 October 2017

Eric Sebzda

1

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17 October 2017

Madelon Bracke

series ordinal

2

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17 October 2017

Tamara Tugal

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3

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17 October 2017

Nancy Hogg

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4

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17 October 2017

language of work or name

English

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publication date

11 February 2002

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17 October 2017

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17 October 2017

volume

3

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17 October 2017

issue

3

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17 October 2017

page(s)

251-258

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Costimulation through CD28 suppresses T cell receptor-dependent activation of the Ras-like small GTPase Rap1 in human T lymphocytes

17 October 2017

cites work

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7 January 2021

Activation of the Rap1 GTPase by the B cell antigen receptor

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7 January 2021

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7 January 2021

RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts

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7 January 2021

Ras and Rap1: two highly related small GTPases with distinct function

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7 January 2021

Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1

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7 January 2021

Combinatorial effect of T-cell receptor ligation and CD45 isoform expression on the signaling contribution of the small GTPases Ras and Rap1.

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7 January 2021

CD28 and the tyrosine kinase lck stimulate mitogen-activated protein kinase activity in T cells via inhibition of the small G protein Rap1.

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7 January 2021

Spatio-temporal images of growth-factor-induced activation of Ras and Rap1.

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7 January 2021

Rap1 is activated by erythropoietin or interleukin-3 and is involved in regulation of beta1 integrin-mediated hematopoietic cell adhesion

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7 January 2021

The GTPase Rap1 controls functional activation of macrophage integrin alphaMbeta2 by LPS and other inflammatory mediators

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7 January 2021

Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase

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7 January 2021

The small GTPase, Rap1, mediates CD31-induced integrin adhesion

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7 January 2021

Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion

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7 January 2021

CD98 induces LFA-1-mediated cell adhesion in lymphoid cells via activation of Rap1.

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7 January 2021

Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap

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7 January 2021

Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor

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7 January 2021

Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice

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7 January 2021

Raf regulates positive selection

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7 January 2021

Selective requirement for MAP kinase activation in thymocyte differentiation

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7 January 2021

Positive and negative selection invoke distinct signaling pathways.

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7 January 2021

Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

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7 January 2021

CD69 expression during selection and maturation of CD4+8+ thymocytes.

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7 January 2021

Discrimination between maintenance- and differentiation-inducing signals during initial and intermediate stages of positive selection

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7 January 2021

Involvement of p21ras activation in T cell CD69 expression

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7 January 2021

Raf-1 provides a dominant but not exclusive signal for the induction of CD69 expression on T cells

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7 January 2021

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

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7 January 2021

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

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7 January 2021

Tolerance induction by clonal deletion of CD4+8+ thymocytes in vitro does not require dedicated antigen-presenting cells

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7 January 2021

Mature T cell reactivity altered by peptide agonist that induces positive selection

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7 January 2021

Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation

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7 January 2021

Regulation of leukocyte integrin function: affinity vs. avidity

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7 January 2021

Divalent cation regulation of the function of the leukocyte integrin LFA-1

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7 January 2021

Lipopolysaccharide-induced activation of beta2-integrin function in macrophages requires Irak kinase activity, p38 mitogen- activated protein kinase, and the Rap1 GTPase

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7 January 2021

LFA-1-mediated adhesion is regulated by cytoskeletal restraint and by a Ca2+-dependent protease, calpain

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7 January 2021

The actin cytoskeleton regulates LFA-1 ligand binding through avidity rather than affinity changes

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7 January 2021

PI 3-K and T-cell activation: limitations of T-leukemic cell lines as signaling models.

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7 January 2021

Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

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7 January 2021

Viral escape at the molecular level explained by quantitative T-cell receptor/peptide/MHC interactions and the crystal structure of a peptide/MHC complex

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7 January 2021

ZAP-70 tyrosine kinase is required for LFA-1-dependent T cell migration

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7 January 2021

Regulation of beta 1 integrin-mediated adhesion by T cell receptor signaling involves ZAP-70 but differs from signaling events that regulate transcriptional activity

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7 January 2021

A novel function for the Tec family tyrosine kinase Itk in activation of beta 1 integrins by the T-cell receptor

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7 January 2021

Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap

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7 January 2021

Coupling of the TCR to integrin activation by Slap-130/Fyb.

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7 January 2021

Identifiers

DOI

10.1038/NI765

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17 October 2017

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