(Q42208602)

18 October 2017

title

Overexpression of human IGF-I via direct rAAV-mediated gene transfer improves the early repair of articular cartilage defects in vivo (English)

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18 October 2017

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M Cucchiarini

1

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18 October 2017

H Madry

series ordinal

2

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18 October 2017

publication date

3 July 2014

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18 October 2017

number of pages

9

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inferred from page(s)

published in

Gene Therapy

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18 October 2017

volume

21

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18 October 2017

issue

9

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18 October 2017

page(s)

811-819

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https://scigraph.springernature.com/pub.10.1038/gt.2014.58

18 October 2017

exact match

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cites work

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Articular cartilage repair by genetically modified bone marrow aspirate in sheep.

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Adeno-associated viral gene transfer of transforming growth factor-beta1 to human mesenchymal stem cells improves cartilage repair

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Acceleration of cartilage repair by genetically modified chondrocytes over expressing bone morphogenetic protein-7.

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Direct delayed human adenoviral BMP-2 or BMP-6 gene therapy for bone and cartilage regeneration in a pony osteochondral model

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The influence of the stable expression of BMP2 in fibrin clots on the remodelling and repair of osteochondral defects.

21 January 2018

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Combined effects of connective tissue growth factor-modified bone marrow-derived mesenchymal stem cells and NaOH-treated PLGA scaffolds on the repair of articular cartilage defect in rabbits.

21 January 2018

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The promotion of cartilage defect repair using adenovirus mediated Sox9 gene transfer of rabbit bone marrow mesenchymal stem cells

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Direct rAAV SOX9 administration for durable articular cartilage repair with delayed terminal differentiation and hypertrophy in vivo

21 January 2018

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Zinc-finger protein 145, acting as an upstream regulator of SOX9, improves the differentiation potential of human mesenchymal stem cells for cartilage regeneration and repair

21 January 2018

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Repair of articular cartilage defects in rabbits using CDMP1 gene-transfected autologous mesenchymal cells derived from bone marrow.

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Insulin-like growth factor-I enhances cell-based repair of articular cartilage

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Degradable hydrogel scaffolds for in vivo delivery of single and dual growth factors in cartilage repair.

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Osteochondral tissue regeneration using a bilayered composite hydrogel with modulating dual growth factor release kinetics in a rabbit model.

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Genetic modification of chondrocytes with insulin-like growth factor-1 enhances cartilage healing in an equine model

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Reconstruct large osteochondral defects of the knee with hIGF-1 gene enhanced Mosaicplasty

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Enhanced repair of articular cartilage defects in vivo by transplanted chondrocytes overexpressing insulin-like growth factor I (IGF-I).

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Metabolic activities and chondrogenic differentiation of human mesenchymal stem cells following recombinant adeno-associated virus-mediated gene transfer and overexpression of fibroblast growth factor 2.

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SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells

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rAAV-mediated overexpression of TGF-β stably restructures human osteoarthritic articular cartilage in situ

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Benefits of recombinant adeno-associated virus (rAAV)-mediated insulinlike growth factor I (IGF-I) overexpression for the long-term reconstruction of human osteoarthritic cartilage by modulation of the IGF-I axis

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Adenoviral-mediated transfer of TGF-beta1 but not IGF-1 induces chondrogenic differentiation of human mesenchymal stem cells in pellet cultures

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Insulin-like growth factor I releasing silk fibroin scaffolds induce chondrogenic differentiation of human mesenchymal stem cells

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Disruption of insulin-like growth factor-I expression in type IIalphaI collagen-expressing cells reduces bone length and width in mice

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IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway

21 January 2018

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Sox9/Sox6 and Sp1 are involved in the insulin-like growth factor-I-mediated upregulation of human type II collagen gene expression in articular chondrocytes.

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Transgenic mice with osteoblast-targeted insulin-like growth factor-I show increased bone remodeling

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Insulin-like growth factor-I induces early osteoblast gene expression in human mesenchymal stem cells

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IL-1ra/IGF-1 gene therapy modulates repair of microfractured chondral defects

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Remodelling of human osteoarthritic cartilage by FGF-2, alone or combined with Sox9 via rAAV gene transfer

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Igf-I extends the chondrogenic potential of human articular chondrocytes in vitro: Molecular association between Sox9 and Erk1/2

21 January 2018

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Use of genetically modified muscle and fat grafts to repair defects in bone and cartilage

21 January 2018

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7 January 2021

Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells

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https://api.crossref.org/works/10.1038%2FGT.2014.58

7 January 2021

Cartilage and bone regeneration using gene-enhanced tissue engineering

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https://api.crossref.org/works/10.1038%2FGT.2014.58

7 January 2021

Improved tissue repair in articular cartilage defects in vivo by rAAV-mediated overexpression of human fibroblast growth factor 2

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https://api.crossref.org/works/10.1038%2FGT.2014.58

7 January 2021

Local stimulation of articular cartilage repair by transplantation of encapsulated chondrocytes overexpressing human fibroblast growth factor 2 (FGF-2) in vivo

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https://api.crossref.org/works/10.1038%2FGT.2014.58

7 January 2021

SOX trio-co-transduced adipose stem cells in fibrin gel to enhance cartilage repair and delay the progression of osteoarthritis in the rat

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https://api.crossref.org/works/10.1038%2FGT.2014.58

7 January 2021

Chondromodulin 1 stabilizes the chondrocyte phenotype and inhibits endochondral ossification of porcine cartilage repair tissue

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https://api.crossref.org/works/10.1038%2FGT.2014.58

7 January 2021

Enhanced repair of extensive articular defects by insulin-like growth factor-I-laden fibrin composites

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https://api.crossref.org/works/10.1038%2FGT.2014.58

7 January 2021

Cartilage constructs engineered from chondrocytes overexpressing IGF-I improve the repair of osteochondral defects in a rabbit model.

1 reference

https://api.crossref.org/works/10.1038%2FGT.2014.58

7 January 2021

The effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on the healing of full-thickness defects of articular cartilage

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https://api.crossref.org/works/10.1038%2FGT.2014.58

7 January 2021

Effect of somatomedin-C/insulin-like growth factor I and growth hormone on cultured growth plate and articular chondrocytes

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https://api.crossref.org/works/10.1038%2FGT.2014.58

7 January 2021

Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: increased trabecular bone volume without increased osteoblast proliferation

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https://api.crossref.org/works/10.1038%2FGT.2014.58

7 January 2021

Identifiers

DOI

10.1038/GT.2014.58

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Dimensions Publication ID

18 October 2017

1045596721

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