(Q42232469)

19 October 2017

Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety (English)

1 reference

19 October 2017

32

Ravi P Nargund

1 reference

19 October 2017

Shuwen He

1

1 reference

19 October 2017

Qingmei Hong

2

1 reference

19 October 2017

Zhong Lai

3

1 reference

19 October 2017

David X Yang

4

1 reference

19 October 2017

Pauline C Ting

5

1 reference

19 October 2017

Jeffrey T Kuethe

6

1 reference

19 October 2017

Timothy A Cernak

7

1 reference

19 October 2017

Kevin D Dykstra

8

1 reference

19 October 2017

Donald M Sperbeck

9

1 reference

19 October 2017

Zhicai Wu

10

1 reference

19 October 2017

Yang Yu

11

1 reference

19 October 2017

Ginger X Yang

12

1 reference

19 October 2017

Tianying Jian

13

1 reference

19 October 2017

Jian Liu

14

1 reference

19 October 2017

Deodial Guiadeen

15

1 reference

19 October 2017

Arto D Krikorian

16

1 reference

19 October 2017

Lisa M Sonatore

17

1 reference

19 October 2017

Judyann Wiltsie

18

1 reference

19 October 2017

Jinqi Liu

19

1 reference

19 October 2017

Judith N Gorski

20

1 reference

19 October 2017

Christine C Chung

21

1 reference

19 October 2017

Jack T Gibson

22

1 reference

19 October 2017

JeanMarie Lisnock

23

1 reference

19 October 2017

Jianying Xiao

24

1 reference

19 October 2017

Michael Wolff

25

1 reference

19 October 2017

Sharon X Tong

26

1 reference

19 October 2017

Maria Madeira

27

1 reference

19 October 2017

Bindhu V Karanam

28

1 reference

19 October 2017

Dong-Ming Shen

29

1 reference

19 October 2017

James M Balkovec

30

1 reference

19 October 2017

Shirly Pinto

31

1 reference

19 October 2017

Robert J DeVita

33

1 reference

19 October 2017

8 September 2014

1 reference

ACS Medicinal Chemistry Letters

19 October 2017

1 reference

19 October 2017

5

1 reference

19 October 2017

1082-1087

1 reference

19 October 2017

10

1 reference

Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety

19 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207266

Intestinally Targeted Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitors Robustly Suppress Postprandial Triglycerides

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207266

Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207266

Identification and characterization of sebaceous gland atrophy-sparing DGAT1 inhibitors

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207266

Adenosine A2A receptor as a drug discovery target

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207266

Current status of the research and development of diacylglycerol O-acyltransferase 1 (DGAT1) inhibitors

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207266

Recent developments in adenosine receptor ligands and their potential as novel drugs

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207266

DGAT1 inhibitors as anti-obesity and anti-diabetic agents.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207266

Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207266

Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207266

Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207266

Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207266

Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207266

Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687).

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207266

Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release--potential insight into mechanism of action.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207266

ACAT-selective and nonselective DGAT1 inhibition: adrenocortical effects--a cross-species comparison.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207266

Proof of mechanism for the DGAT1 inhibitor AZD7687: results from a first-time-in-human single-dose study.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207266

Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of acyl-CoA:diacylglycerol acyltransferase 1.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207266

Synthesis of the first sulfur-35-labeled hERG radioligand

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207266

Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:diacylglycerol acyltransferase 1.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207266

Diacylglycerol acyltransferase 1 inhibition with AZD7687 alters lipid handling and hormone secretion in the gut with intolerable side effects: a randomized clinical trial

17 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25349648

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Comparative evaluation of in silico systems for ames test mutagenicity prediction: scope and limitations

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25349648

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ML5003426

1 reference

19 October 2017

1 reference

19 October 2017

1 reference