(Q42283688)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22014153%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

title

Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22014153%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22014153%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Anne M Filppula

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22014153%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Janne Backman

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22014153%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

author name string

J Laitila

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22014153%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

language of work or name

English

0 references

publication date

1 April 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22014153%20AND%20SRC:MED&resulttype=core&format=json

British Journal of Pharmacology

14 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22014153%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

volume

165

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22014153%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22014153%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

page(s)

2787-2798

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22014153%20AND%20SRC:MED&resulttype=core&format=json

Guide to Receptors and Channels (GRAC), 5th edition

14 January 2020

cites work

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26 October 2017

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Seeking the causes and solutions to imatinib-resistance in chronic myeloid leukemia

26 October 2017

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Participation of CYP2C8 and CYP3A4 in the N‐demethylation of imatinib in human hepatic microsomes

26 October 2017

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Targeted cancer therapies in the twenty-first century: lessons from imatinib

26 October 2017

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Managing imatinib resistance in chronic myeloid leukaemia

26 October 2017

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Imatinib in the treatment of solid tumours

26 October 2017

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Mechanism-based inhibition of cytochrome P450 enzymes: an evaluation of early decision making in vitro approaches and drug-drug interaction prediction methods

26 October 2017

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Methods for predicting in vivo pharmacokinetics using data from in vitro assays

26 October 2017

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Grapefruit juice-drug interaction studies as a method to assess the extent of intestinal availability: utility and limitations.

26 October 2017

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Cytochrome p450 turnover: regulation of synthesis and degradation, methods for determining rates, and implications for the prediction of drug interactions

26 October 2017

1 reference

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Effects of imatinib (Glivec) on the pharmacokinetics of metoprolol, a CYP2D6 substrate, in Chinese patients with chronic myelogenous leukaemia

26 October 2017

1 reference

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Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring

26 October 2017

1 reference

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Part I: mechanisms of resistance to imatinib in chronic myeloid leukaemia

26 October 2017

1 reference

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How I treat chronic myeloid leukemia in the imatinib era.

26 October 2017

1 reference

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Philadelphia chromosome-positive acute lymphoblastic leukemia: impact of imatinib treatment on remission induction and allogeneic stem cell transplantation

26 October 2017

1 reference

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The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions

26 October 2017

1 reference

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Clinical pharmacokinetics of imatinib

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423228

Population pharmacokinetics of imatinib mesylate in patients with chronic-phase chronic myeloid leukaemia: results of a phase III study

26 October 2017

1 reference

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Active transport of imatinib into and out of cells: implications for drug resistance

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423228

In vitro blood distribution and plasma protein binding of the tyrosine kinase inhibitor imatinib and its active metabolite, CGP74588, in rat, mouse, dog, monkey, healthy humans and patients with acute lymphatic leukaemia

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423228

Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome P450 3A4 substrate, in patients with chronic myeloid leukaemia

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423228

Esters of methanesulfonic acid as irreversible inhibitors of acetylcholinesterase

26 October 2017

1 reference

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Time course of recovery of cytochrome p450 3A function after single doses of grapefruit juice

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423228

MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models

26 October 2017

1 reference

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Grapefruit juice-simvastatin interaction: effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors

26 October 2017

1 reference

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Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport

26 October 2017

1 reference

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An in vitro model for predicting in vivo inhibition of cytochrome P450 3A4 by metabolic intermediate complex formation.

26 October 2017

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Prediction of time-dependent CYP3A4 drug-drug interactions by physiologically based pharmacokinetic modelling: impact of inactivation parameters and enzyme turnover.

29 May 2018

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Population pharmacokinetics and pharmacogenetics of imatinib in children and adults.

17 August 2018

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Multidrug resistance gene (MDR1) polymorphisms are associated with major molecular responses to standard-dose imatinib in chronic myeloid leukemia.

17 August 2018

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In vitro biotransformation of imatinib by the tumor expressed CYP1A1 and CYP1B1.

17 August 2018

1 reference

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Influence of CYP3A4 inhibition on the steady-state pharmacokinetics of imatinib

17 August 2018

1 reference

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Fragmentation study of imatinib and characterization of new imatinib metabolites by liquid chromatography-triple-quadrupole and linear ion trap mass spectrometers

17 August 2018

1 reference

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Metabolism and disposition of imatinib mesylate in healthy volunteers

17 August 2018

1 reference

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Impact of parallel pathways of drug elimination and multiple cytochrome P450 involvement on drug-drug interactions: CYP2D6 paradigm.

17 August 2018

1 reference

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Validated assays for human cytochrome P450 activities

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423228

Pharmacokinetic interaction between ketoconazole and imatinib mesylate (Glivec) in healthy subjects

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423228

Pharmacokinetics and pharmacodynamics of imatinib in a phase I trial with chronic myeloid leukemia patients

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423228

Absolute bioavailability of imatinib (Glivec) orally versus intravenous infusion

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423228

Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423228

Pharmacokinetics and cellular uptake of imatinib and its main metabolite CGP74588.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423228

Simvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazole.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423228

Complex interaction of BCRP/ABCG2 and imatinib in BCR-ABL-expressing cells: BCRP-mediated resistance to imatinib is attenuated by imatinib-induced reduction of BCRP expression

17 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01732.X

Imatinib Disposition and ABCB1 (MDR1, P-Glycoprotein) Genotype

21 January 2018

1 reference

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https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01732.X

Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions

21 January 2018

1 reference

12 December 2020

Mechanism-based enzyme inactivators

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12 December 2020

Inhibition and induction of cytochrome P450 and the clinical implications

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12 December 2020

'In silico' simulations to assess the 'in vivo' consequences of 'in vitro' metabolic drug-drug interactions

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12 December 2020

Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia

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12 December 2020

Diltiazem inhibition of cytochrome P-450 3A activity is due to metabolite intermediate complex formation

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12 December 2020

10.1111/J.1476-5381.2011.01732.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22014153%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22014153%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

PubMed publication ID

22014153

1 reference