(Q42284817)

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Current knowledge on the mechanism of atherosclerosis and pro-atherosclerotic properties of oxysterols

scientific article published on 2 October 2017

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scholarly article

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Europe PubMed Central

19 October 2017

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19 November 2019

26 October 2022

Current knowledge on the mechanism of atherosclerosis and pro-atherosclerotic properties of oxysterols (English)

1 reference

Europe PubMed Central

19 October 2017

1 reference

8 August 2019

1 reference

13 November 2019

LDL cholesterol

1 reference

19 November 2019

atherosclerosis

1 reference

19 November 2019

low-density lipoprotein

1 reference

Adam Zmysłowski

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28969682%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Arkadiusz Szterk

2

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1 June 2020

author name string

Adam Zmysłowski

1

1 reference

Europe PubMed Central

19 October 2017

Arkadiusz Szterk

2

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Europe PubMed Central

19 October 2017

language of work or name

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inferred from title

publication date

2 October 2017

8 references

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19 October 2017

22 March 2019

24 March 2019

17 June 2019

8 August 2019

13 November 2019

19 November 2019

26 October 2022

Lipids in Health and Disease

8 references

22 March 2019

24 March 2019

17 June 2019

8 August 2019

13 November 2019

19 November 2019

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28969682%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

26 October 2022

16

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1 June 2020

1

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1 June 2020

188

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1 June 2020

copyright license

Creative Commons Attribution 4.0 International

7 references

Europe PubMed Central

22 March 2019

Europe PubMed Central

24 March 2019

Europe PubMed Central

17 June 2019

Europe PubMed Central

8 August 2019

Europe PubMed Central

13 November 2019

Europe PubMed Central

19 November 2019

Europe PubMed Central

26 October 2022

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on focus list of Wikimedia project

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https://scigraph.springernature.com/pub.10.1186/s12944-017-0579-2

0 references

Oxysterols and 4-hydroxy-2-nonenal contribute to atherosclerotic plaque destabilization.

1 reference

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26 October 2017

Current Knowledge about Oxysterols: A Review.

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Impact of Cooking, Storage, and Reheating Conditions on the Formation of Cholesterol Oxidation Products in Pork Loin.

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Plant sterols, cholesterol precursors and oxysterols: Minute concentrations-Major physiological effects

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26 October 2017

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

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The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha

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Endothelial dysfunction: the early predictor of atherosclerosis.

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Cholesterol-5,6-epoxides: chemistry, biochemistry, metabolic fate and cancer.

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26 October 2017

The role of oxysterols in control of endothelial stiffness

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26 October 2017

Smooth muscle cell phenotypic switching in atherosclerosis

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26 October 2017

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Estrogens and atherosclerosis: insights from animal models and cell systems

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Coronary heart disease in young adults

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26 October 2017

Progress and challenges in translating the biology of atherosclerosis

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26 October 2017

Mechanisms of oxysterol-induced carcinogenesis.

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26 October 2017

Mechanisms of LDL oxidation

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26 October 2017

High-density lipoprotein heterogeneity and function in reverse cholesterol transport

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26 October 2017

The NO cascade, eNOS location, and microvascular permeability

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26 October 2017

The NF-kappaB family of transcription factors and its regulation

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26 October 2017

Oxidized LDL: diversity, patterns of recognition, and pathophysiology

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26 October 2017

Cytotoxic effects of oxysterols associated with human diseases: Induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis.

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26 October 2017

Monocyte-endothelial cell interactions in the development of atherosclerosis

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26 October 2017

Macrophage scavenger receptors and host-derived ligands

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26 October 2017

Regulation and characteristics of vascular smooth muscle cell phenotypic diversity.

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26 October 2017

CD36 and macrophages in atherosclerosis

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26 October 2017

Oxysterol mixtures, in atheroma-relevant proportions, display synergistic and proapoptotic effects

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26 October 2017

Mechanotransduction and the glycocalyx

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26 October 2017

Role of cholesterol and lipid organization in disease

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26 October 2017

Activation of caspase-3-dependent and -independent pathways during 7-ketocholesterol- and 7beta-hydroxycholesterol-induced cell death: a morphological and biochemical study

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26 October 2017

Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice

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26 October 2017

Differential effects of mixtures of cholesterol oxidation products on bovine aortic endothelial cells and human monocytic U937 cells

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26 October 2017

Generation of an oxidative stress precedes caspase activation during 7beta-hydroxycholesterol-induced apoptosis in U937 cells

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26 October 2017

Oxysterol mixtures prevent proapoptotic effects of 7-ketocholesterol in macrophages: implications for proatherogenic gene modulation

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26 October 2017

Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625595

26 October 2017

Oxysterols induce apoptosis and accumulation of cell cycle at G(2)/M phase in the human monocytic THP-1 cell line

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26 October 2017

Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime

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26 October 2017

Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages

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26 October 2017

Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36

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26 October 2017

Lipoprotein size and atherosclerosis susceptibility in Apoe(-/-) and Ldlr(-/-) mice.

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26 October 2017

Structure of apolipoprotein B-100 in low density lipoproteins.

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26 October 2017

Lysosomal destabilization during macrophage damage induced by cholesterol oxidation products

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26 October 2017

Structure of low density lipoprotein (LDL) particles: basis for understanding molecular changes in modified LDL.

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26 October 2017

Aggregation, fusion, and vesicle formation of modified low density lipoprotein particles: molecular mechanisms and effects on matrix interactions

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26 October 2017

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26 October 2017

The oxidative modification hypothesis of atherogenesis: an overview

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26 October 2017

Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1.

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26 October 2017

Oxidized cholesterol in the diet accelerates the development of atherosclerosis in LDL receptor- and apolipoprotein E-deficient mice

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26 October 2017

Cholesterol and oxysterol metabolism and subcellular distribution in macrophage foam cells. Accumulation of oxidized esters in lysosomes

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26 October 2017

Chemokines and atherosclerosis

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26 October 2017

LDL particle size: an important drug target?

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26 October 2017

Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice

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26 October 2017

Role of group II secretory phospholipase A2 in atherosclerosis: 1. Increased atherogenesis and altered lipoproteins in transgenic mice expressing group IIa phospholipase A2.

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26 October 2017

Characterization and comparison of the mode of cell death, apoptosis versus necrosis, induced by 7beta-hydroxycholesterol and 7-ketocholesterol in the cells of the vascular wall

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26 October 2017

Induction of apoptosis in endothelial cells treated with cholesterol oxides

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26 October 2017

TGF-beta 1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify.

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26 October 2017

Oxidized low density lipoprotein leads to macrophage accumulation of unesterified cholesterol as a result of lysosomal trapping of the lipoprotein hydrolyzed cholesteryl ester.

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26 October 2017

7 beta-hydroperoxycholest-5-en-3 beta-ol, a component of human atherosclerotic lesions, is the primary cytotoxin of oxidized human low density lipoprotein

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26 October 2017

The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters.

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26 October 2017

Visualization of the binding, endocytosis, and transcytosis of low-density lipoprotein in the arterial endothelium in situ

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26 October 2017

Complete cDNA and derived protein sequence of human apolipoprotein B-100.

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26 October 2017

Cholesterol autoxidation 1981-1986.

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26 October 2017

Angiotoxicity and atherogenicity of cholesterol oxides

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26 October 2017

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26 October 2017

Nitric oxide inhibits platelet adhesion to collagen through cGMP-dependent and independent mechanisms: the potential role for S-nitrosylation

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29 May 2018

Effect of cell turnover and leaky junctions on arterial macromolecular transport.

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29 May 2018

Vascular effects of oxysterols and oxyphytosterols in apoE -/- mice.

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17 August 2018

Oxidised plant sterols as well as oxycholesterol increase the proportion of severe atherosclerotic lesions in female LDL receptor+/ - mice.

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17 August 2018

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17 August 2018

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17 August 2018

Mapping oxidations of apolipoprotein B-100 in human low-density lipoprotein by liquid chromatography-tandem mass spectrometry.

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17 August 2018

Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis

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17 August 2018

The role of the mitochondria in apoptosis induced by 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide

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17 August 2018

A mechanosensory complex that mediates the endothelial cell response to fluid shear stress

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17 August 2018

7-Ketocholesterol induces reversible cytochrome c release in smooth muscle cells in absence of mitochondrial swelling

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17 August 2018

Trojan horse-like behavior of a biologically representative mixture of oxysterols

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17 August 2018

Oxidized cholesterol in the diet is a source of oxidized lipoproteins in human serum

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17 August 2018

Dietary cholesterol-oxidation products accumulate in serum and liver in apolipoprotein E-deficient mice, but do not accelerate atherosclerosis

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17 August 2018

Effects of dietary oxysterols on coronary arteries in hyperlipidaemic hamsters

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17 August 2018

12/15-Lipoxygenase gene disruption attenuates atherogenesis in LDL receptor-deficient mice

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17 August 2018

Pressurized liquid extraction of lipids for the determination of oxysterols in egg-containing food.

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17 August 2018

Ceramide generation occurring during 7beta-hydroxycholesterol- and 7-ketocholesterol-induced apoptosis is caspase independent and is not required to trigger cell death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625595

17 August 2018

Impairment with various antioxidants of the loss of mitochondrial transmembrane potential and of the cytosolic release of cytochrome c occuring during 7-ketocholesterol-induced apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625595

17 August 2018

Oxidized cholesterol in the diet accelerates the development of aortic atherosclerosis in cholesterol-fed rabbits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625595

17 August 2018

Transport of side-chain oxidized oxysterols in the human circulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625595

17 August 2018

Sterol efflux is impaired from macrophage foam cells selectively enriched with 7-ketocholesterol.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625595

17 August 2018

A macrophage Fc receptor for IgG is also a receptor for oxidized low density lipoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5625595

17 August 2018

Absorption of Cholesterol Oxidation Products from Ordinary Foodstuff in Humans

1 reference

https://api.crossref.org/works/10.1186%2FS12944-017-0579-2

21 January 2018

Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6C hi and Ly6C lo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice

1 reference

https://api.crossref.org/works/10.1186%2FS12944-017-0579-2

21 January 2018

Sequence, structure, receptor-binding domains and internal repeats of human apolipoprotein B-100

1 reference

https://api.crossref.org/works/10.1186%2FS12944-017-0579-2

21 January 2018

Oxysterol-induced apoptosis in human monocytic cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary oxysterols are incorporated in plasma triglyceride-rich lipoproteins, increase their susceptibility to oxidation and increase aortic cholesterol concentration of rabbits

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proapoptotic effects of ANG II in human coronary artery endothelial cells: role of AT1 receptor and PKC activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione is implied in the control of 7-ketocholesterol-induced apoptosis, which is associated with radical oxygen species production

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sphingomyelinase Induces Aggregation and Fusion, but Phospholipase A2Only Aggregation, of Low Density Lipoprotein (LDL) Particles

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

7beta-hydroxycholesterol induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxysterols induced apoptosis in cultured smooth muscle cells through CPP32 protease activation and bcl-2 protein downregulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of cholesterol oxidation products from animal fat using aminopropyl solid-phase extraction

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Patterns of atherosclerosis and their surgical significance

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoelectron microscopic visualization of the transcytosis of low density lipoproteins in perfused rat arteries

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early stages of LDL oxidation: apolipoprotein B structural changes monitored by infrared spectroscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipids of human atherosclerotic plaques and xanthomas: clues to the mechanism of plaque progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein A-I-mediated efflux of sterols from oxidized LDL-loaded macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholesterol transformations during heat treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the low density lipoprotein receptor in penetration of low density lipoprotein into rabbit aortic wall

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The in vivo transfer of free and esterified cholesterol from plasma into the arterial wall of hypercholesterolemic rabbits

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New method to determine free sterols/oxysterols in food matrices using gas chromatography and ion trap mass spectrometry (GC-IT-MS)

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

7-Hydroperoxycholesterol and its products in oxidized low density lipoprotein and human atherosclerotic plaque

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of two lipoproteins containing apolipoproteins B and E from lesion-free human aortic intima

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of P-selectin expression in human endothelial cells by nitric oxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Esterification of oxysterols in human serum: effects on distribution and cellular uptake

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of cholesterol-rich diets with and without added vitamins E and C on the severity of atherosclerosis in rabbits

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

25-Hydroxycholesterol activates a cytochrome c release-mediated caspase cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of oxidizing cholesterol on gastrointestinal absorption, plasma clearance, tissue distribution, and processing by endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Summary of American Heart Association Diet and Lifestyle Recommendations revision 2006

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Free and esterified oxysterol: formation during copper-oxidation of low density lipoprotein and uptake by macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lymphatic absorption of oxidized cholesterol in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative atherogenic effects of cholesterol and cholesterol oxides

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sphingomyelinase, an enzyme implicated in atherogenesis, is present in atherosclerotic lesions and binds to specific components of the subendothelial extracellular matrix

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absorption of dietary cholesterol oxidation products and incorporation into rat lymph chylomicrons

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of modified apolipoprotein B-100 structures formed in oxidized low-density lipoprotein using LC-MS/MS

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atherogenesis in white carneau pigeons. Effects of low-level cholestane-triol feeding

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolytic enzymes of mast cell granules degrade low density lipoproteins and promote their granule-mediated uptake by macrophages in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxysterols and atherosclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of MCP-1 in atherosclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo accuracy of multispectral magnetic resonance imaging for identifying lipid-rich necrotic cores and intraplaque hemorrhage in advanced human carotid plaques

1 reference

https://pubmed.ncbi.nlm.nih.gov/28969682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/S12944-017-0579-2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28969682%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28969682%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28969682%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Sitelinks

Wikipedia(0 entries)

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Wikiquote(0 entries)

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