(Q42288961)

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HER3 targeting of adenovirus by fiber modification increases infection of breast cancer cells in vitro, but not following intratumoral injection in mice.

scientific article published on 26 October 2012

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16 February 2020

HER3 targeting of adenovirus by fiber modification increases infection of breast cancer cells in vitro, but not following intratumoral injection in mice (English)

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16 February 2020

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16 February 2020

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S H MacLeod

1

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16 February 2020

M M Elgadi

2

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16 February 2020

U Sankar

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16 February 2020

A Pisio

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16 February 2020

K Agopsowicz

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16 February 2020

D Sharon

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16 February 2020

F L Graham

8

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16 February 2020

M M Hitt

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16 February 2020

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26 October 2012

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16 February 2020

Cancer Gene Therapy

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16 February 2020

19

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16 February 2020

12

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16 February 2020

888-898

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16 February 2020

https://scigraph.springernature.com/pub.10.1038/cgt.2012.79

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Current status of gendicine in China: recombinant human Ad-p53 agent for treatment of cancers

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Clinical trials with oncolytic adenovirus in China

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Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5

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Receptors mediating adenovirus attachment and internalization.

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HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses

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What does it take to bind CAR?

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Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment

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Integrin alpha v beta 5 selectively promotes adenovirus mediated cell membrane permeabilization.

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CAR: a virus receptor within the tight junction

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Expression of coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers

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The presence of human coxsackievirus and adenovirus receptor is associated with efficient adenovirus-mediated transgene expression in human melanoma cell cultures

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Coxsackie B and adenovirus receptor, integrin and major histocompatibility complex class I expression in human prostate cancer cell lines: implications for gene therapy strategies.

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Genetic targeting of adenoviral vectors

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Current advances and future challenges in Adenoviral vector biology and targeting

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Structure of adenovirus fibre. I. Analysis of crystals of fibre from adenovirus serotypes 2 and 5 by electron microscopy and X-ray crystallography

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Deletion analysis of functional domains in baculovirus-expressed adenovirus type 2 fiber

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Crystal structure of the receptor-binding domain of adenovirus type 5 fiber protein at 1.7 A resolution

1 reference

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A triple beta-spiral in the adenovirus fibre shaft reveals a new structural motif for a fibrous protein

1 reference

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21 January 2018

Ablating adenovirus type 5 fiber-CAR binding and HI loop insertion of the SIGYPLP peptide generate an endothelial cell-selective adenovirus

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21 January 2018

Fiber-modified adenovirus vectors containing the TAT peptide derived from HIV-1 in the fiber knob have efficient gene transfer activity

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21 January 2018

Modulation of adenovirus vector tropism via incorporation of polypeptide ligands into the fiber protein

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Identification of heregulin, a specific activator of p185erbB2

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Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells

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Identification of a heregulin binding site in HER3 extracellular domain

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Heregulin induces tyrosine phosphorylation of HER4/p180erbB4

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A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling

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The structural basis for the specificity of epidermal growth factor and heregulin binding

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High-resolution solution structure of the EGF-like domain of heregulin-alpha

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Expression of the ERBB3 gene product in breast cancer

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The ErbB receptors and their role in cancer progression.

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The status and role of ErbB receptors in human cancer.

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Ligand-directed retroviral targeting of human breast cancer cells

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Intratumoral injection of an adenovirus expressing interleukin 2 induces regression and immunity in a murine breast cancer model

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Characteristics of a human cell line transformed by DNA from human adenovirus type 5

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Production and characterization of human 293 cell lines expressing the site-specific recombinase Cre.

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Single-step assembly of a gene and entire plasmid from large numbers of oligodeoxyribonucleotides

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A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal

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Both the 5' untranslated region and the sequences surrounding the start site contribute to efficient initiation of translation in vitro

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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An enhanced system for construction of adenoviral vectors by the two-plasmid rescue method

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Ectodomain of coxsackievirus and adenovirus receptor genetically fused to epidermal growth factor mediates adenovirus targeting to epidermal growth factor receptor-positive cells

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Adaptable modification of adenoviral tropism using a bifunctional ligand protein

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Engineering of adenovirus vectors containing heterologous peptide sequences in the C terminus of capsid protein IX.

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A simplified system for constructing recombinant adenoviral vectors containing heterologous peptides in the HI loop of their fiber knob

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Recombinant human adenovirus: targeting to the human transferrin receptor improves gene transfer to brain microcapillary endothelium

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Bovine adenovirus type 3 containing heterologous protein in the C-terminus of minor capsid protein IX.

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Retargeting of adenovirus vectors through genetic fusion of a single-chain or single-domain antibody to capsid protein IX.

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Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types

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Cryo-EM visualization of an exposed RGD epitope on adenovirus that escapes antibody neutralization

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Cytotoxicity and specificity of directed toxins composed of diphtheria toxin and the EGF-like domain of heregulin beta1.

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Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling

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Heregulin reverses the oligomerization of HER3.

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Identification of a conserved receptor-binding site on the fiber proteins of CAR-recognizing adenoviridae

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Vitronectin receptor antibodies inhibit infection of HeLa and A549 cells by adenovirus type 12 but not by adenovirus type 2.

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Characterization of the knob domain of the adenovirus type 5 fiber protein expressed in Escherichia coli

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An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism

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Bioactive synthetic peptide of NDF/heregulin

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NDF/heregulin stimulates the phosphorylation of Her3/erbB3

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7 January 2021

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Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4

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The polypeptides of adenovirus. I. Evidence for multiple protein components in the virion and a comparison of types 2, 7A, and 12

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Covalently closed circles of human adenovirus DNA are infectious.

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Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins.

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10.1038/CGT.2012.79

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16 February 2020

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16 February 2020

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