(Q42369564)

28 October 2017

Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1. (English)

1 reference

28 October 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27452468%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Essam Ghazaly

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27452468%20AND%20SRC:MED&resulttype=core&format=json

Maria Perpétua Mota Freitas

11 June 2020

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27452468%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Marta O. Freitas

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27452468%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Cristiana Lo Nigro

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27452468%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Jun Wang

9

1 reference

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11 June 2020

Claude Chelala

10

1 reference

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11 June 2020

author name string

Mikaella Mitsinga

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27452468%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Laura Lattanzio

6

1 reference

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11 June 2020

Ai Nagano

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27452468%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Peter Szlosarek

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27452468%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Sarah A Martin

12

1 reference

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11 June 2020

publication date

20 July 2016

1 reference

28 October 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27452468%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

volume

16

1 reference

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11 June 2020

issue

6

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11 June 2020

page(s)

1604-1613

1 reference

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describes a project that uses

11 June 2020

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/4978703

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

1 reference

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Amino acid management in cancer

29 May 2018

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limma powers differential expression analyses for RNA-sequencing and microarray studies

29 May 2018

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Down-regulation of argininosuccinate synthetase is associated with cisplatin resistance in hepatocellular carcinoma cell lines: implications for PEGylated arginine deiminase combination therapy.

29 May 2018

1 reference

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The role of arginine and the modified arginine deiminase enzyme ADI-PEG 20 in cancer therapy with special emphasis on Phase I/II clinical trials

29 May 2018

1 reference

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Serine and glycine metabolism in cancer

29 May 2018

1 reference

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Polyamines in biological samples: rapid and robust quantification by solid-phase extraction online-coupled to liquid chromatography-tandem mass spectrometry

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4978703

Prognostic and therapeutic impact of argininosuccinate synthetase 1 control in bladder cancer as monitored longitudinally by PET imaging

29 May 2018

1 reference

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Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction

29 May 2018

1 reference

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ASS1 as a novel tumor suppressor gene in myxofibrosarcomas: aberrant loss via epigenetic DNA methylation confers aggressive phenotypes, negative prognostic impact, and therapeutic relevance

29 May 2018

1 reference

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Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4978703

Passenger deletions generate therapeutic vulnerabilities in cancer

29 May 2018

1 reference

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Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4978703

Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis.

29 May 2018

1 reference

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O-miner: an integrative platform for automated analysis and mining of -omics data.

29 May 2018

1 reference

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Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models

29 May 2018

1 reference

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Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4978703

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4978703

Simultaneous bioanalysis of L-arginine, L-citrulline, and dimethylarginines by LC-MS/MS.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4978703

Glutamine addiction: a new therapeutic target in cancer

29 May 2018

1 reference

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Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

29 May 2018

1 reference

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Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4978703

Resistance to arginine deiminase treatment in melanoma cells is associated with induced argininosuccinate synthetase expression involving c-Myc/HIF-1alpha/Sp4.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4978703

IDH1 and IDH2 mutations in gliomas

29 May 2018

1 reference

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Cross-platform Q-TOF validation of global exo-metabolomic analysis: application to human glioblastoma cells treated with the standard PI 3-Kinase inhibitor LY294002.

29 May 2018

1 reference

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Arginine deprivation as a targeted therapy for cancer

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4978703

Arginine and glycine stimulate creatine synthesis in creatine transporter 1-deficient lymphoblasts.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4978703

Polyamine acetylation modulates polyamine metabolic flux, a prelude to broader metabolic consequences

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4978703

In vivo loss of expression of argininosuccinate synthetase in malignant pleural mesothelioma is a biomarker for susceptibility to arginine depletion

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4978703

Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer.

29 May 2018

1 reference

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Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates

29 May 2018

1 reference

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Polyamines and cancer: old molecules, new understanding

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4978703

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4978703

Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4978703

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4978703

Polyamines: new cues in cellular signal transduction

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4978703

Role of polyamines in mediating malignant transformation and oncogene expression

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4978703

Mucosal polyamine measurements and colorectal cancer risk.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4978703

Colonic polyamine content and ornithine decarboxylase activity as markers for adenomas

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4978703

Deficiency in expression and epigenetic DNA Methylation of ASS1 gene in nasopharyngeal carcinoma: negative prognostic impact and therapeutic relevance

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4978703

Determination of polyamine metabolome in plasma and urine by ultrahigh performance liquid chromatography-tandem mass spectrometry method: application to identify potential markers for human hepatic cancer

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4978703

Metabolic response to pegylated arginine deiminase in mesothelioma with promoter methylation of argininosuccinate synthetase

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4978703

Upregulation of ornithine decarboxylase mRNA expression in Barrett's esophagus and Barrett's-associated adenocarcinoma.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4978703

10.1016/J.CELREP.2016.06.097

17 August 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27452468%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27452468%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference