(Q42400888)

English

Prolyl Hydroxylase Domain (PHD) 2 Affects Cell Migration and F-actin Formation via RhoA/Rho-associated Kinase-dependent Cofilin Phosphorylation

scientific article published on August 27, 2010

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scholarly article

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Europe PubMed Central

PMC publication ID

29 October 2017

Prolyl hydroxylase domain (PHD) 2 affects cell migration and F-actin formation via RhoA/rho-associated kinase-dependent cofilin phosphorylation (English)

1 reference

Europe PubMed Central

PMC publication ID

29 October 2017

Prolyl Hydroxylase Domain (PHD) 2 Affects Cell Migration and F-actin Formation via RhoA/Rho-associated Kinase-dependent Cofilin Phosphorylation (English)

1 reference

10.1074/JBC.M110.132985

https://api.crossref.org/works/10.1074/JBC.M110.132985

3 July 2024

phosphorylation

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Sabine Vogel

1

1 reference

Europe PubMed Central

PMC publication ID

29 October 2017

Marieke Wottawa

2

1 reference

Europe PubMed Central

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29 October 2017

Katja Farhat

3

1 reference

Europe PubMed Central

PMC publication ID

29 October 2017

Anke Zieseniss

4

1 reference

Europe PubMed Central

PMC publication ID

29 October 2017

Moritz Schnelle

5

1 reference

Europe PubMed Central

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29 October 2017

Sinja Le-Huu

6

1 reference

Europe PubMed Central

PMC publication ID

29 October 2017

Melanie von Ahlen

7

1 reference

Europe PubMed Central

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29 October 2017

Cordula Malz

8

1 reference

Europe PubMed Central

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29 October 2017

Gieri Camenisch

9

1 reference

Europe PubMed Central

PMC publication ID

29 October 2017

Dörthe M. Katschinski

10

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20801873

3 July 2024

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27 August 2010

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29 October 2017

full work available at URL

http://www.jbc.org/article/S0021925820470875/pdf

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20801873

3 July 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20801873/pdf/?tool=EBI

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20801873

3 July 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20801873/?tool=EBI

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1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20801873

3 July 2024

http://intl.jbc.org/cgi/content/abstract/285/44/33756

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20801873

3 July 2024

https://europepmc.org/articles/PMC2962474

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content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20801873

3 July 2024

https://europepmc.org/articles/PMC2962474?pdf=render

Portable Document Format

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20801873

3 July 2024

https://doi.org/10.1074/jbc.m110.132985

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20801873

3 July 2024

https://api.elsevier.com/content/article/PII:S0021925820470875?httpAccept=text/xml

1 reference

10.1074/JBC.M110.132985

https://api.crossref.org/works/10.1074/JBC.M110.132985

3 July 2024

https://api.elsevier.com/content/article/PII:S0021925820470875?httpAccept=text/plain

1 reference

10.1074/JBC.M110.132985

https://api.crossref.org/works/10.1074/JBC.M110.132985

3 July 2024

https://syndication.highwire.org/content/doi/10.1074/jbc.M110.132985

1 reference

10.1074/JBC.M110.132985

https://api.crossref.org/works/10.1074/JBC.M110.132985

3 July 2024

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

29 October 2017

285

1 reference

Europe PubMed Central

PMC publication ID

29 October 2017

44

1 reference

Europe PubMed Central

PMC publication ID

29 October 2017

33756-33763

1 reference

Europe PubMed Central

PMC publication ID

29 October 2017

Inhibition of hypoxia-inducible factor-targeting prolyl hydroxylase domain-containing protein 2 (PHD2) enhances matrix synthesis by human chondrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962474

28 May 2018

Control of actin filament treadmilling in cell motility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962474

28 May 2018

ADF/cofilin: a functional node in cell biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962474

28 May 2018

Epithelial-mesenchymal transitions in development and disease

1 reference

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28 May 2018

HIF prolyl 4-hydroxylases and their potential as drug targets

1 reference

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28 May 2018

Role of hypoxia in the hallmarks of human cancer

1 reference

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28 May 2018

Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment

1 reference

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28 May 2018

Rho GTPase function in tumorigenesis

1 reference

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28 May 2018

In vivo functions of the prolyl-4-hydroxylase domain oxygen sensors: direct route to the treatment of anaemia and the protection of ischaemic tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962474

28 May 2018

Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962474

28 May 2018

iTRAQ proteomic identification of pVHL-dependent and -independent targets of Egln1 prolyl hydroxylase knockdown in renal carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962474

28 May 2018

Ins and outs of ADF/cofilin activity and regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962474

28 May 2018

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962474

28 May 2018

The actin cytoskeleton in cancer cell motility

1 reference

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28 May 2018

Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962474

28 May 2018

The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962474

28 May 2018

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962474

28 May 2018

The cofilin pathway in breast cancer invasion and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962474

28 May 2018

Hypoxia, gene expression, and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962474

28 May 2018

Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962474

28 May 2018

Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962474

28 May 2018

Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962474

28 May 2018

Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962474

28 May 2018

Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962474

28 May 2018

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962474

28 May 2018

The role of iron and 2-oxoglutarate oxygenases in signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962474

28 May 2018

HIF-1α mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962474

28 May 2018

Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962474

28 May 2018

Polarised migration: cofilin holds the front.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962474

28 May 2018

Structural insights into actin-binding, branching and bundling proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962474

28 May 2018

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

1 reference

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28 May 2018

Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression

1 reference

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28 May 2018

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

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28 May 2018

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

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28 May 2018

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

1 reference

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28 May 2018

Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

1 reference

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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28 May 2018

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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Small G-protein networks: their crosstalk and signal cascades.

1 reference

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Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop

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28 May 2018

Visualising the actin cytoskeleton

1 reference

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28 May 2018

Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization

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28 May 2018

Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase

1 reference

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The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

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Increased chemoresistance induced by inhibition of HIF-prolyl-hydroxylase domain enzymes

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Regulation of the SM-20 prolyl hydroxylase gene in smooth muscle cells

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Mammalian EGLN genes have distinct patterns of mRNA expression and regulation

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Assembling an actin cytoskeleton for cell attachment and movement

1 reference

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Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor

1 reference

https://pubmed.ncbi.nlm.nih.gov/20801873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Visualising the actin cytoskeleton

25

1 reference

10.1074/JBC.M110.132985

https://api.crossref.org/works/10.1074/JBC.M110.132985

3 July 2024

Biochimica et Biophysica Acta

46

1796

91

author name string

Karlsson

publication date

2009

1 reference

10.1074/JBC.M110.132985

https://api.crossref.org/works/10.1074/JBC.M110.132985

3 July 2024

Identifiers

10.1074/JBC.M110.132985

1 reference

Europe PubMed Central

PMC publication ID

29 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

29 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

29 October 2017

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