(Q42441155)

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Extended treatment with selective phosphatidylinositol 3-kinase and mTOR inhibitors has effects on metabolism, growth, behaviour and bone strength

scientific article published on 12 August 2013

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Europe PubMed Central

PubMed publication ID

31 October 2017

Extended treatment with selective phosphatidylinositol 3-kinase and mTOR inhibitors has effects on metabolism, growth, behaviour and bone strength (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 October 2017

Michelle Dickinson

8

object named as

Michelle Dickinson

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Europe PubMed Central

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31 October 2017

7

object named as

Greg D Gamble

1 reference

Europe PubMed Central

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31 October 2017

Jillian Cornish

5

object named as

Jillian Cornish

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31 October 2017

author name string

Greg C Smith

1

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31 October 2017

Wee-Kiat Ong

2

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31 October 2017

Jessica L Costa

3

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Europe PubMed Central

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31 October 2017

Maureen Watson

4

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Europe PubMed Central

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31 October 2017

Andrew Grey

6

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Europe PubMed Central

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31 October 2017

Sophie Leung

9

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31 October 2017

Gordon W Rewcastle

10

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31 October 2017

Weiping Han

11

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31 October 2017

Peter R Shepherd

12

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31 October 2017

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publication date

12 August 2013

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31 October 2017

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31 October 2017

280

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31 October 2017

21

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31 October 2017

5337-5349

1 reference

Europe PubMed Central

PubMed publication ID

31 October 2017

PI3K signalling: the path to discovery and understanding.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

The Akt kinases: isoform specificity in metabolism and cancer

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Membrane recognition by phospholipid-binding domains

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Role of protein kinase B in insulin-regulated glucose uptake.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Bridging the GAP between insulin signaling and GLUT4 translocation

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

A role for protein kinase Bbeta/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Insulin signaling diverges into Akt-dependent and -independent signals to regulate the recruitment/docking and the fusion of GLUT4 vesicles to the plasma membrane

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Investigating the role of class-IA PI 3-kinase isoforms in adipocyte differentiation

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Phosphatidylinositol 3-kinase inhibitors block differentiation of skeletal muscle cells

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

The skeleton: a multi-functional complex organ: new insights into osteoblasts and their role in bone formation: the central role of PI3Kinase

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Important roles of PI3Kgamma in osteoclastogenesis and bone homeostasis

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Inhibitory effects of ZSTK474, a novel phosphoinositide 3-kinase inhibitor, on osteoclasts and collagen-induced arthritis in mice

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

NVP-BEZ235, a dual pan class I PI3 kinase and mTOR inhibitor, promotes osteogenic differentiation in human mesenchymal stromal cells.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Evidence for a role for the p110-alpha isoform of PI3K in skeletal function

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Effects of PI3K inhibition and low docosahexaenoic acid on cognition and behavior

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Local infusion of ghrelin enhanced hippocampal synaptic plasticity and spatial memory through activation of phosphoinositide 3-kinase in the dentate gyrus of adult rats

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

High frequency of mutations of the PIK3CA gene in human cancers

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Functional differences between two classes of oncogenic mutation in the PIK3CA gene

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Progress in the preclinical discovery and clinical development of class I and dual class I/IV phosphoinositide 3-kinase (PI3K) inhibitors

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Recognizing and exploiting differences between RNAi and small-molecule inhibitors

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Lifelong accumulation of bone in mice lacking Pten in osteoblasts

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Both p110alpha and p110beta isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

The role of Akt1 in terminal stages of endochondral bone formation: angiogenesis and ossification

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Akt1 in osteoblasts and osteoclasts controls bone remodeling

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Reduced body weight and increased energy expenditure in transgenic mice over-expressing soluble leptin receptor

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

A recurring problem with the analysis of energy expenditure in genetic models expressing lean and obese phenotypes

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

In vitro and in vivo effects of adiponectin on bone

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Skeletal phenotype of the leptin receptor-deficient db/db mouse

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12428

21 January 2018

Identifiers

10.1111/FEBS.12428

1 reference

Europe PubMed Central

PubMed publication ID

31 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 October 2017

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