(Q42452984)

31 October 2017

Role of PTEN and Akt in the regulation of growth and apoptosis in human osteoblastic cells (English)

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31 October 2017

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3 April 2024

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3 April 2024

author name string

Sheila M. Nielsen-Preiss

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14624456

3 April 2024

Selina R. Silva

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14624456

3 April 2024

Jennifer M. Gillette

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14624456

3 April 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14624456

3 April 2024

publication date

1 December 2003

1 reference

full work available at URL

31 October 2017

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjcb.10709

1 reference

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcb.10709

3 April 2024

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Journal of Cellular Biochemistry

3 April 2024

published in

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31 October 2017

90

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31 October 2017

964-975

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31 October 2017

5

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Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

31 October 2017

1

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The phosphoinositide 3-kinase pathway

3 April 2024

2

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

3 April 2024

3

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Induction of osteoblast differentiation indexes by PTHrP in MG-63 cells involves multiple signaling pathways

3 April 2024

4

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The cell survival signal Akt is differentially activated by PDGF-BB, EGF, and FGF-2 in osteoblastic cells

3 April 2024

5

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PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies

3 April 2024

6

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Calcium regulates the PI3K-Akt pathway in stretched osteoblasts

3 April 2024

7

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

3 April 2024

8

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Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN

3 April 2024

9

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Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

3 April 2024

10

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Drug-induced apoptosis in osteosarcoma cell lines is mediated by caspase activation independent of CD95-receptor/ligand interaction

3 April 2024

11

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Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription.

3 April 2024

12

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Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors

3 April 2024

13

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Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways

3 April 2024

15

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Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay

3 April 2024

16

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A nude mouse model of human osteosarcoma lung metastases for evaluating new therapeutic strategies

3 April 2024

17

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Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

3 April 2024

19

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A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

3 April 2024

20

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Localization of a novel tumor suppressor locus on human chromosome 3q important in osteosarcoma tumorigenesis

3 April 2024

21

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The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes quiescent but not proliferating MG-63 human osteosarcoma cells to radiation

3 April 2024

22

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Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

3 April 2024

23

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A role for nuclear PTEN in neuronal differentiation.

3 April 2024

24

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MDM2 gene amplification in metastatic osteosarcoma

3 April 2024

25

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Erk is essential for growth, differentiation, integrin expression, and cell function in human osteoblastic cells

3 April 2024

27

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Reversible inactivation of the tumor suppressor PTEN by H2O2

3 April 2024

28

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Tumor suppressor PTEN is mutated in canine osteosarcoma cell lines and tumors

3 April 2024

29

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

3 April 2024

30

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PTEN mutation is rare in chondrosarcoma.

3 April 2024

31

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Involvement of ERK in BMP-2 induced osteoblastic differentiation of mesenchymal progenitor cell line C3H10T1/2.

3 April 2024

32

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

3 April 2024

33

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A sensitive assay for phosphoinositide phosphatases

3 April 2024

34

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Chemotherapy for nonmetastatic osteogenic sarcoma: the Memorial Sloan-Kettering experience

3 April 2024

35

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Osteogenic sarcoma with clinically detectable metastasis at initial presentation

3 April 2024

36

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P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

3 April 2024

38

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The lipid phosphatase activity of PTEN is critical for its tumor supressor function

3 April 2024

39

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The Ras/Raf/MEK/extracellular signal-regulated kinase pathway induces autocrine-paracrine growth inhibition via the leukemia inhibitory factor/JAK/STAT pathway

3 April 2024

40

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Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells

3 April 2024

41

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Induction in human osteoblastic cells (SaOS2) of the early response genes fos, jun, and myc by the amino terminal fragment (ATF) of urokinase

3 April 2024

42

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Terminal differentiation and apoptosis in experimental lung metastases of human osteogenic sarcoma cells by wild type p53

3 April 2024

43

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Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

3 April 2024

44

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Systemic relapse of patients with osteogenic sarcoma. Prognostic factors for long term survival

3 April 2024

45

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Complete association of loss of heterozygosity of chromosomes 13 and 17 in osteosarcoma

3 April 2024

46

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Inhibition of phosphatidylinositol 3-kinase and p70S6 kinase blocks osteogenic protein-1 induction of alkaline phosphatase activity in fetal rat calvaria cells

3 April 2024

47

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Identification of two essential phosphorylated threonine residues in the catalytic domain of Mekk1. Indirect activation by Pak3 and protein kinase C

3 April 2024

48

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Activations of ERK1/2 and JNK by transforming growth factor beta negatively regulate Smad3-induced alkaline phosphatase activity and mineralization in mouse osteoblastic cells

3 April 2024

49

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Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

3 April 2024

50

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

3 April 2024

51

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

3 April 2024

52

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Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis

3 April 2024

53

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PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

3 April 2024

54

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Chromosomal reorganization for the expression of recessive mutation of retinoblastoma susceptibility gene in the development of osteosarcoma

3 April 2024

55

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Assignment of common allele loss in osteosarcoma to the subregion 17p13

3 April 2024

56

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Mutation spectrum of the retinoblastoma gene in osteosarcomas

3 April 2024

59

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PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model

3 April 2024

61

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PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways

3 April 2024

62

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Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

3 April 2024

63

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The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

3 April 2024

64

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ERK pathway mediates the activation of Cdk2 in IGF-1-induced proliferation of human osteosarcoma MG-63 cells

3 April 2024

66

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3 April 2024

Identifiers

DOI

10.1002/JCB.10709

1 reference

31 October 2017

1 reference