(Q42462954)

English

Mepyramine, a histamine H1 receptor inverse agonist, binds preferentially to a G protein-coupled form of the receptor and sequesters G protein.

scientific article published on 10 June 2004

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15192105%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Mepyramine, a histamine H1 receptor inverse agonist, binds preferentially to a G protein-coupled form of the receptor and sequesters G protein (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15192105%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

G protein-coupled receptor

0 references

Carlos Fitzsimons

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15192105%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

author name string

Federico Monczor

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15192105%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Natalia Fernández

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15192105%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Carina Shayo

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15192105%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Carlos Davio

5

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15192105%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

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publication date

10 June 2004

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15192105%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Journal of Biological Chemistry

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15192105%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

279

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15192105%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

33

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29 December 2019

34431-34439

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15192105%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Mechanisms of inverse agonism at G-protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400738200

21 January 2018

The two-state model of receptor activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400738200

21 January 2018

The cubic ternary complex receptor-occupancy model. III. resurrecting efficacy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400738200

21 January 2018

Tiotidine, a histamine H2 receptor inverse agonist that binds with high affinity to an inactive G-protein-coupled form of the receptor. Experimental support for the cubic ternary complex model

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400738200

21 January 2018

Selective ligands as tools to study histamine receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400738200

21 January 2018

Constitutive activity of the histamine H(1) receptor reveals inverse agonism of histamine H(1) receptor antagonists

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400738200

21 January 2018

Biochemical characterization of desloratadine, a potent antagonist of the human histamine H(1) receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400738200

21 January 2018

Regulation of phospholipase C activation by the number of H(2) receptors during Ca(2+)-induced differentiation of mouse keratinocytes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400738200

21 January 2018

Reduction of G protein-coupled receptor kinase 2 expression in U-937 cells attenuates H2 histamine receptor desensitization and induces cell maturation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400738200

21 January 2018

Heterogeneity of [3H]-mepyramine binding sites in guinea pig cerebellum and lung.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400738200

21 January 2018

Identification and characterization of histamine H1- and H2-receptors in guinea-pig left atrial membranes by [3H]-mepyramine and [3H]-tiotidine binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400738200

21 January 2018

Drug efficacy at G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400738200

21 January 2018

Analysis of Apparent Noncompetitive Responses to Competitive H(1)-Histamine Receptor Antagonists in Fluorescent Imaging Plate Reader-Based Calcium Assays.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400738200

21 January 2018

Human adenosine A1 receptor and P2Y2-purinoceptor-mediated activation of the mitogen-activated protein kinase cascade in transfected CHO cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400738200

21 January 2018

Increases in intracellular calcium via activation of an endogenous P2-purinoceptor in cultured CHO-K1 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400738200

21 January 2018

Dimers of class A G protein-coupled receptors function via agonist-mediated trans-activation of associated G proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400738200

21 January 2018

Emerging safety issues regarding long-term usage of H(1)receptor antagonists

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400738200

21 January 2018

Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400738200

21 January 2018

Preclinical comparison of ebastine and other second generation H1-antihistamines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400738200

21 January 2018

Mechanisms of agonism and inverse agonism at serotonin 5-HT1A receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400738200

21 January 2018

Insurmountable AT(1) receptor antagonism: the need for different antagonist binding states of the receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400738200

21 January 2018

Evidence that the apparent complexity of receptor antagonism by angiotensin II analogues is due to a reversible and syntopic action

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400738200

21 January 2018

Agonist-antagonist interactions at angiotensin receptors: application of a two-state receptor model

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400738200

21 January 2018

Mutational analysis of the antagonist-binding site of the histamine H(1) receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400738200

21 January 2018

Identifiers

10.1074/JBC.M400738200

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15192105%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15192105%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

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