(Q42491408)

1 November 2017

title

cAMP-secretion coupling is impaired in diabetic GK/Par rat β-cells: a defect counteracted by GLP-1. (English)

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1 November 2017

Manuel Dolz

1

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1 November 2017

Jamileh Movassat

2

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1 November 2017

Danielle Bailbé

3

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1 November 2017

Hervé Le Stunff

4

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1 November 2017

Marie-Hélène Giroix

5

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1 November 2017

Magali Fradet

6

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1 November 2017

Micheline Kergoat

7

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1 November 2017

Bernard Portha

8

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publication date

12 July 2011

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American Journal of Physiology - Endocrinology and Metabolism

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published in

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1 November 2017

volume

301

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1 November 2017

issue

5

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1 November 2017

page(s)

E797-806

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Mutations in the promoter of adenylyl cyclase (AC)-III gene, overexpression of AC-III mRNA, and enhanced cAMP generation in islets from the spontaneously diabetic GK rat model of type 2 diabetes

1 November 2017

cites work

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Glucagon-like peptide-1(7-36)-amide confers glucose sensitivity to previously glucose-incompetent beta-cells in diabetic rats: in vivo and in vitro studies

21 January 2018

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Restitution of defective glucose-stimulated insulin secretion in diabetic GK rat by acetylcholine uncovers paradoxical stimulatory effect of beta-cell muscarinic receptor activation on cAMP production

21 January 2018

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Oscillations of cyclic AMP in hormone-stimulated insulin-secreting beta-cells

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Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilization

21 January 2018

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Glucose enhances adenylyl cyclase responses in normal but not diabetic GK rat islets

21 January 2018

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The calcium/calmodulin-dependent phosphodiesterase PDE1C down-regulates glucose-induced insulin secretion

21 January 2018

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Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulin

21 January 2018

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Regulation of insulin secretion: a matter of phase control and amplitude modulation

21 January 2018

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Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37).

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Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling.

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Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion

21 January 2018

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Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line

21 January 2018

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Constitutively active stimulatory G-protein alpha s in beta-cells of transgenic mice causes counterregulation of the increased adenosine 3',5'-monophosphate and insulin secretion

21 January 2018

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21 January 2018

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cAMP-GEFII is a direct target of cAMP in regulated exocytosis

21 January 2018

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Decreased ADP-ribosylation of the Galpha(olf) and Galpha(s) subunits by high glucose in pancreatic B-cells

21 January 2018

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Overexpression of Gs proteins and adenylyl cyclase in normal and diabetic islets

21 January 2018

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PACAP is expressed in secretory granules of insulin and glucagon cells in human and rodent pancreas. Evidence for generation of cAMP compartments uncoupled from hormone release in diabetic islets

21 January 2018

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The GK rat beta-cell: a prototype for the diseased human beta-cell in type 2 diabetes?

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21 January 2018

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Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells

21 January 2018

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21 January 2018

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The Adenylate cyclase-cyclic AMP system in islets of langerhans and its role in the control of insulin release

21 January 2018

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Glucagon-Like Peptide 1(7-36) Amide Stimulates Exocytosis in Human Pancreatic -Cells by Both Proximal and Distal Regulatory Steps in Stimulus-Secretion Coupling

21 January 2018

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10.1152/AJPENDO.00652.2010

21 January 2018

Identifiers

DOI

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1 November 2017

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