(Q42491656)

1 November 2017

title

AKT1 provides an essential survival signal required for differentiation and stratification of primary human keratinocytes (English)

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1 November 2017

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Barry R Thrash

1

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1 November 2017

Craig W Menges

series ordinal

2

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1 November 2017

Robert H Pierce

series ordinal

3

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1 November 2017

Dennis J McCance

series ordinal

4

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1 November 2017

language of work or name

English

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publication date

3 March 2006

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Journal of Biological Chemistry

1 November 2017

published in

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1 November 2017

volume

281

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1 November 2017

issue

17

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1 November 2017

page(s)

12155-12162

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Getting under the skin of epidermal morphogenesis

1 November 2017

cites work

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Role of integrins in regulating epidermal adhesion, growth and differentiation

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Integrins and anoikis

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Signal transduction pathways controlling the switch between keratinocyte growth and differentiation

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p63 is the molecular switch for initiation of an epithelial stratification program

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mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

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Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.

21 January 2018

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Myogenic signaling of phosphatidylinositol 3-kinase requires the serine-threonine kinase Akt/protein kinase B.

21 January 2018

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Positive feedback regulation between Akt2 and MyoD during muscle differentiation. Cloning of Akt2 promoter

21 January 2018

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Cell cycle withdrawal promotes myogenic induction of Akt, a positive modulator of myocyte survival

21 January 2018

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Insulin-like growth factor-mediated muscle cell survival: central roles for Akt and cyclin-dependent kinase inhibitor p21

21 January 2018

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Human papillomavirus type 16 alters human epithelial cell differentiation in vitro

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Hoxb13 up-regulates transglutaminase activity and drives terminal differentiation in an epidermal organotypic model

21 January 2018

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Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin

21 January 2018

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Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: contrasting roles of FOXN1 and Akt.

21 January 2018

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Phosphoinositide 3-kinase signaling to Akt promotes keratinocyte differentiation versus death.

21 January 2018

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Cellular survival: a play in three Akts

21 January 2018

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Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

21 January 2018

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Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

21 January 2018

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Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site.

21 January 2018

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NF-kappaB determines localization and features of cell death in epidermis

21 January 2018

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Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation

21 January 2018

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Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing

21 January 2018

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Ultrastructural localization of caspase-14 in human epidermis

21 January 2018

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Epidermal differentiation, apoptosis, and senescence: common pathways?

21 January 2018

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Caspase activation in the terminal differentiation of human epidermal keratinocytes

21 January 2018

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Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

21 January 2018

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Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice.

21 January 2018

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NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.

21 January 2018

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Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest

21 January 2018

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In vivo cooperation between Bcl-xL and the phosphoinositide 3-kinase-Akt signaling pathway for the protection of epidermal keratinocytes from apoptosis.

21 January 2018

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Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

21 January 2018

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Direct control of the Forkhead transcription factor AFX by protein kinase B

21 January 2018

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

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NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

21 January 2018

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Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

21 January 2018

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Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512116200

Phosphatidylinositol 3-kinase controls human intestinal epithelial cell differentiation by promoting adherens junction assembly and p38 MAPK activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512116200

Akt/PKB localisation and 3' phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512116200

Evidence that apoptosis and terminal differentiation of epidermal keratinocytes are distinct processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512116200

Phosphatidylinositol 3-Kinase Is a Key Regulator of Early Phase Differentiation in Keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512116200

21 January 2018

Identifiers

DOI

10.1074/JBC.M512116200

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1 November 2017

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