(Q42515491)

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ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity.

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Europe PubMed Central

PubMed publication ID

1 November 2017

ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758654&resulttype=core&format=json

12 May 2020

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1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758654&resulttype=core&format=json

12 May 2020

Clifford J. Woolf

4

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Clifford J Woolf

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758654&resulttype=core&format=json

12 May 2020

author name string

Katia Befort

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758654&resulttype=core&format=json

12 May 2020

Gary J Brenner

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758654&resulttype=core&format=json

12 May 2020

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publication date

1 January 2002

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

Journal of Neuroscience

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758654&resulttype=core&format=json

12 May 2020

22

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758654&resulttype=core&format=json

12 May 2020

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758654&resulttype=core&format=json

12 May 2020

478-485

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758654&resulttype=core&format=json

12 May 2020

The contribution of spinal cord neurokinin-1 receptor signaling to pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spinal cord substance P receptor immunoreactivity increases in both inflammatory and nerve injury models of persistent pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunocytochemical localization of trkA receptors in chemically identified subgroups of adult rat sensory neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pronociceptive actions of dynorphin maintain chronic neuropathic pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of transcription factor CREB in rat spinal cord after formalin-induced hyperalgesia: relationship to c-fos induction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation-induced upregulation of NK1 receptor mRNA in dorsal horn neurones

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphine, the NMDA receptor antagonist MK801 and the tachykinin NK1 receptor antagonist RP67580 attenuate the development of inflammation-induced progressive tactile hypersensitivity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central and peripheral expression of galanin in response to inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peripheral inflammation is associated with increased dynorphin immunoreactivity in both projection and local circuit neurons in the superficial dorsal horn of the rat lumbar spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Null mutations lacking substance: elucidating pain mechanisms by genetic pharmacology

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of c-fos-like protein in spinal cord neurons following sensory stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unilateral inflammation of the hindpaw in rats as a model of prolonged noxious stimulation: alterations in behavior and nociceptive thresholds

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered nociception, analgesia and aggression in mice lacking the receptor for substance P

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spinally administered dynorphin A produces long-lasting allodynia: involvement of NMDA but not opioid receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A requirement for the mitogen-activated protein kinase cascade in hippocampal long term potentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Making new connections: role of ERK/MAP kinase signaling in neuronal plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A noxious stimulus induces the preprotachykinin-A gene expression in the rat dorsal root ganglion: a quantitative study using in situ hybridization histochemistry

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Repetitive transcranial magnetic stimulation activates specific regions in rat brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transmission of chronic nociception by spinal neurons expressing the substance P receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclic GMP pathway is critical for inducing long-term sensitization of nociceptive sensory neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a central component of post-injury pain hypersensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential activities of intrathecal MK-801 or morphine to alter responses to thermal and mechanical stimuli in normal or nerve-injured rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circadian regulation of cAMP response element-mediated gene expression in the suprachiasmatic nuclei

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of immediate early genes in the hippocampus and spinal cord.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ERK plays a regulatory role in induction of LTP by theta frequency stimulation and its modulation by beta-adrenergic receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An isobolographic analysis of the effects of N-methyl-D-aspartate and NK1 tachykinin receptor antagonists on inflammatory hyperalgesia in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurokinin-1 receptors on lumbar spinothalamic neurons in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The MAPK cascade is required for mammalian associative learning

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular characterization of a functional cDNA encoding the rat substance P receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal plasticity: increasing the gain in pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mitogen-activated protein kinase cascade couples PKA and PKC to cAMP response element binding protein phosphorylation in area CA1 of hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spinal substance P receptor expression and internalization in acute, short-term, and long-term inflammatory pain states

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: stimulus specificity, behavioral parameters and opioid receptor binding.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NK-1 and NK-3 type tachykinin receptor mRNA expression in the rat spinal cord dorsal horn is increased during adjuvant or formalin-induced nociception

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The spinal contribution of substance P to the generation and maintenance of inflammatory hyperalgesia in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylated cAMP response element binding protein increases in neurokinin-1 receptor-immunoreactive neurons in rat spinal cord in response to formalin-induced nociception

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In situ hybridization histochemistry and immunocytochemistry reveal an increase in spinal dynorphin biosynthesis in a rat model of peripheral inflammation and hyperalgesia

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of neuropeptide Y and neuropeptide Y (Y1) receptor mRNA in rat spinal cord and dorsal root ganglia following peripheral tissue inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extraterritorial neuropathic pain correlates with multisegmental elevation of spinal dynorphin in nerve-injured rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection by estrogen via extracellular signal-regulated kinase against quinolinic acid-induced cell death in the rat hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity-dependent neuronal plasticity following tissue injury and inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation increases the distribution of dorsal horn neurons that internalize the neurokinin-1 receptor in response to noxious and non-noxious stimulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross talk between ERK and PKA is required for Ca2+ stimulation of CREB-dependent transcription and ERK nuclear translocation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular signal-regulated kinase (ERK) controls immediate early gene induction on corticostriatal stimulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription factor regulation of prodynorphin gene expression following rat hindpaw inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional and posttranslational plasticity and the generation of inflammatory pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of spinal kappa-opioid receptor agonists on the responsiveness of nociceptive superficial dorsal horn neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Organization, structure, and expression of the gene encoding the rat substance P receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of the antiallodynic and antinociceptive efficacy of spinal morphine by antisera to dynorphin A (1-13) or MK-801 in a nerve-ligation model of peripheral neuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relative effectiveness of C primary afferent fibers of different origins in evoking a prolonged facilitation of the flexor reflex in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.22-02-00478.2002

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758654&resulttype=core&format=json

12 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758654&resulttype=core&format=json

12 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758654&resulttype=core&format=json

12 May 2020

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