(Q42536288)

English

The role of FOXO and PPAR transcription factors in diet-mediated inhibition of PDC activation and carbohydrate oxidation during exercise in humans and the role of pharmacological activation of PDC in overriding these changes

scientific article published on 7 February 2012

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

1 November 2017

The role of FOXO and PPAR transcription factors in diet-mediated inhibition of PDC activation and carbohydrate oxidation during exercise in humans and the role of pharmacological activation of PDC in overriding these changes (English)

1 reference

Europe PubMed Central

PMC publication ID

1 November 2017

1 reference

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Francis B. Stephens

3

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Francis Stephens

1 reference

Europe PubMed Central

PMC publication ID

1 November 2017

author name string

Dumitru Constantin-Teodosiu

1

1 reference

Europe PubMed Central

PMC publication ID

1 November 2017

Despina Constantin

2

1 reference

Europe PubMed Central

PMC publication ID

1 November 2017

David Laithwaite

4

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Europe PubMed Central

PMC publication ID

1 November 2017

Paul L Greenhaff

5

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Europe PubMed Central

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1 November 2017

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publication date

7 February 2012

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Europe PubMed Central

PMC publication ID

1 November 2017

1 reference

Europe PubMed Central

PMC publication ID

1 November 2017

61

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Europe PubMed Central

PMC publication ID

1 November 2017

5

1 reference

Europe PubMed Central

PMC publication ID

1 November 2017

1017-1024

1 reference

Europe PubMed Central

PMC publication ID

1 November 2017

copyright license

Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

30 August 2021

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April 2022 Public Data File from Crossref

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0 references

Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle

1 reference

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Pyruvate dehydrogenase kinase 4: regulation by thiazolidinediones and implication in glyceroneogenesis in adipose tissue

1 reference

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Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta

1 reference

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28 May 2018

Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis

1 reference

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Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle.

1 reference

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28 May 2018

Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells

1 reference

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28 May 2018

Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors

1 reference

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28 May 2018

Pyruvate dehydrogenase activation and kinase expression in human skeletal muscle during fasting

1 reference

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28 May 2018

AZD7545, a novel inhibitor of pyruvate dehydrogenase kinase 2 (PDHK2), activates pyruvate dehydrogenase in vivo and improves blood glucose control in obese (fa/fa) Zucker rats

1 reference

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28 May 2018

Suppression of beta cell energy metabolism and insulin release by PGC-1alpha

1 reference

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28 May 2018

Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation

1 reference

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28 May 2018

Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors

1 reference

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28 May 2018

Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16

1 reference

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28 May 2018

Long-term fat diet adaptation effects on performance, training capacity, and fat utilization

1 reference

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28 May 2018

Physiological and therapeutic roles of peroxisome proliferator-activated receptors

1 reference

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Dual promoter structure of mouse and human fatty acid translocase/CD36 genes and unique transcriptional activation by peroxisome proliferator-activated receptor alpha and gamma ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331777

28 May 2018

Human skeletal muscle PDH kinase activity and isoform expression during a 3-day high-fat/low-carbohydrate diet

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331777

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Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans

1 reference

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28 May 2018

Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

1 reference

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28 May 2018

Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331777

28 May 2018

Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331777

28 May 2018

Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331777

28 May 2018

The mammalian pyruvate dehydrogenase complex: structure and regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331777

28 May 2018

Glycogen, glycolytic intermediates and high-energy phosphates determined in biopsy samples of musculus quadriceps femoris of man at rest. Methods and variance of values.

1 reference

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Effects of dichloroacetate on the metabolism of glucose, pyruvate, acetate, 3-hydroxybutyrate and palmitate in rat diaphragm and heart muscle in vitro and on extraction of glucose, lactate, pyruvate and free fatty acids by dog heart in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331777

28 May 2018

Dichloroacetate inhibits glycolysis and augments insulin-stimulated glycogen synthesis in rat muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331777

28 May 2018

Acetyl group accumulation and pyruvate dehydrogenase activity in human muscle during incremental exercise

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331777

28 May 2018

Dichloroacetate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331777

28 May 2018

Insulin regulation of skeletal muscle PDK4 mRNA expression is impaired in acute insulin-resistant states

1 reference

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Muscle pyruvate availability can limit the flux, but not activation, of the pyruvate dehydrogenase complex during submaximal exercise in humans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331777

16 August 2018

Insulin suppresses PDK-4 expression in skeletal muscle independently of plasma FFA.

1 reference

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16 August 2018

Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-activated receptor-alpha ligands, glucocorticoids, and insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331777

16 August 2018

Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha.

1 reference

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16 August 2018

Calculation of substrate oxidation rates in vivo from gaseous exchange.

1 reference

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16 August 2018

High-Fat/Low-Carbohydrate Diet Reduces Insulin-Stimulated Carbohydrate Oxidation but Stimulates Nonoxidative Glucose Disposal in Humans: An Important Role for Skeletal Muscle Pyruvate Dehydrogenase Kinase 4

1 reference

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1 reference

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1 December 2018

Pyruvate overrides inhibition of PDH during exercise after a low-carbohydrate diet

1 reference

https://pubmed.ncbi.nlm.nih.gov/22315317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diet, Muscle Glycogen and Physical Performance

1 reference

https://pubmed.ncbi.nlm.nih.gov/22315317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of diet on the utilization of blood-borne and intramuscular substrates during exercise in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/22315317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioisotopic assays of CoASH and carnitine and their acetylated forms in human skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/22315317

12 December 2020

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inferred from PubMed ID database lookup

A sensitive radioisotopic assay of pyruvate dehydrogenase complex in human muscle tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/22315317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPARdelta agonism induces a change in fuel metabolism and activation of an atrophy programme, but does not impair mitochondrial function in rat skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/22315317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PDC activity and acetyl group accumulation in skeletal muscle during prolonged exercise

1 reference

https://pubmed.ncbi.nlm.nih.gov/22315317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyruvate dehydrogenase activity and acetyl group accumulation during exercise after different diets

1 reference

https://pubmed.ncbi.nlm.nih.gov/22315317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Muscle acetyl group availability is a major determinant of oxygen deficit in humans during submaximal exercise

1 reference

https://pubmed.ncbi.nlm.nih.gov/22315317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic pyruvate dehydrogenase activity in humans: effect of cirrhosis, transplantation, and dichloroacetate

1 reference

https://pubmed.ncbi.nlm.nih.gov/22315317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The importance of pyruvate availability to PDC activation and anaplerosis in human skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/22315317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism responsible for inactivation of skeletal muscle pyruvate dehydrogenase complex in starvation and diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22315317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2337/DB11-0799

1 reference

Europe PubMed Central

PMC publication ID

1 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

1 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

1 November 2017

ResearchGate publication ID

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