(Q42542809)

English

Evolution from heterozygous to homozygous KIT mutation in gastrointestinal stromal tumor correlates with the mechanism of mitotic nondisjunction and significant tumor progression.

scientific article published on 16 May 2008

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scholarly article

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7 January 2020

Evolution from heterozygous to homozygous KIT mutation in gastrointestinal stromal tumor correlates with the mechanism of mitotic nondisjunction and significant tumor progression (English)

1 reference

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7 January 2020

gastrointestinal stromal tumor

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inferred from title

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based on heuristic

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based on heuristic

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tumor progression

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1

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7 January 2020

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Kelly K Hunt

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7 January 2020

author name string

Joseph A Holden

2

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7 January 2020

Haesun Choi

3

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7 January 2020

Jing Zhu

4

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7 January 2020

Elsie F Wu

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7 January 2020

Kimberly A Jones

6

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7 January 2020

John H Ward

7

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7 January 2020

Robert H Andtbacka

8

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7 January 2020

R Lor Randall

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7 January 2020

Courtney L Scaife

10

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7 January 2020

Victor G Prieto

12

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7 January 2020

Austin K Raymond

13

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7 January 2020

Wei Zhang

14

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7 January 2020

Jonathan C Trent

15

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7 January 2020

Robert S Benjamin

16

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7 January 2020

Marsha L Frazier

17

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7 January 2020

publication date

16 May 2008

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7 January 2020

Modern Pathology

1 reference

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7 January 2020

21

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7

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7 January 2020

826-836

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7 January 2020

https://scigraph.springernature.com/pub.10.1038/modpathol.2008.46

0 references

KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

21 January 2018

Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

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PDGFRA activating mutations in gastrointestinal stromal tumors.

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

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Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors.

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

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Gastrointestinal stromal tumours: an update

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

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High-resolution melting amplicon analysis as a method to detect c-kit and platelet-derived growth factor receptor alpha activating mutations in gastrointestinal stromal tumors

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinases as targets for anticancer agents: from inhibitors to useful drugs

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

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Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Imatinib resistance in gastrointestinal stromal tumors.

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

A new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Late resistance to imatinib therapy in a metastatic gastrointestinal stromal tumour is associated with a second KIT mutation

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Antioncogenes and human cancer

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor suppressor genes

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

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Loss of heterozygosity associated with uniparental disomy in breast carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations in gastrointestinal stromal tumors--a population-based study from Northern Norway

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Presence of homozygous KIT exon 11 mutations is strongly associated with malignant clinical behavior in gastrointestinal stromal tumors

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Biology of gastrointestinal stromal tumors.

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Allelic variation in gene expression identified through computational analysis of the dbEST database

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Detection of c-kit-activating mutations in gastrointestinal stromal tumors by high-resolution amplicon melting analysis.

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Gastrointestinal stromal tumors with internal tandem duplications in 3' end of KIT juxtamembrane domain occur predominantly in stomach and generally seem to have a favorable course

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Newly identified c-KIT receptor tyrosine kinase ITD in childhood AML induces ligand-independent growth and is responsive to a synergistic effect of imatinib and rapamycin

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Spontaneous canine mast cell tumors express tandem duplications in the proto-oncogene c-kit

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

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Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Immunohistochemical and genetic features of gastric and metastatic liver gastrointestinal stromal tumors: sequential analyses

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

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Expression of the normal factor V allele modulates the APC resistance phenotype in heterozygous carriers of the factor V Leiden mutation

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Multiple gastrointestinal stromal tumors with a germline c-kit mutation.

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Gastrointestinal stromal tumors: insights from a new familial GIST kindred with unusual genetic and pathologic features

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity.

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Somatic recombination redux.

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Gene conversion is a frequent mechanism of inactivation of the wild-type allele in cancers from MLH1/MSH2 deletion carriers.

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Chromosome loss with concomitant duplication and recombination both contribute most to loss of heterozygosity in vitro

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice.

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Nondisjunction--a view from ringside

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines.

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct and indirect non-disjunction in the origin of trisomy in cultured human lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2008.46

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Identifiers

10.1038/MODPATHOL.2008.46

1 reference

Europe PubMed Central

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7 January 2020

Dimensions Publication ID

0 references

1 reference

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7 January 2020

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