(Q42546311)

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A structure-guided mutational analysis of simian virus 40 large T antigen: identification of surface residues required for viral replication and transformation

scientific article published on 24 June 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

A structure-guided mutational analysis of simian virus 40 large T antigen: identification of surface residues required for viral replication and transformation (English)

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

mutational analysis

1 reference

based on heuristic

inferred from title

object named as

simian virus 40

1 reference

based on heuristic

inferred from title

author name string

Deepika Ahuja

1

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

Abhilasha V Rathi

2

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

Amy E Greer

3

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

Xiaojiang S Chen

4

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

James M Pipas

5

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

language of work or name

0 references

publication date

24 June 2009

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

Journal of Virology

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

83

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

17

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

8781-8788

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

SV40: Cell transformation and tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

Complete nucleotide sequence of polyomavirus SA12.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

Transformation by the simian virus 40 T antigen is regulated by IGF-I receptor and IRS-1 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

Simian virus 40 large T antigen's association with the CUL7 SCF complex contributes to cellular transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

p53 targets simian virus 40 large T antigen for acetylation by CBP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

SV40 T antigen interacts with Nbs1 to disrupt DNA replication control.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

SV40 large T-antigen disturbs the formation of nuclear DNA-repair foci containing MRE11.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

Inhibition of Rb and p53 is insufficient for SV40 T-antigen transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

Cellular transformation by SV40 large T antigen: interaction with host proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

The molecular chaperone activity of simian virus 40 large T antigen is required to disrupt Rb-E2F family complexes by an ATP-dependent mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

The replication protein A binding site in simian virus 40 (SV40) T antigen and its role in the initial steps of SV40 DNA replication.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

Binding and modulation of p53 by p300/CBP coactivators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

Simian virus 40 large T antigen binds to topoisomerase I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

The adenovirus E1A-associated 300 kDa adaptor protein counteracts the inhibition of the collagenase promoter by E1A and represses transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

An interaction between replication protein A and SV40 T antigen appears essential for primosome assembly during SV40 DNA replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

Simian virus 40 large T antigen contains two independent activities that cooperate with a ras oncogene to transform rat embryo fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

Mutational Analysis of Simian Virus 40 T Antigen: Isolation and Characterization of Mutants with Deletions in the T-Antigen Gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

Construction and Characterization of Viable Deletion Mutants of Simian Virus 40 Lacking Sequences near the 3′ End of the Early Region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

p53 and DNA polymerase alpha compete for binding to SV40 T antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

Mutations near the carboxyl terminus of the simian virus 40 large tumor antigen alter viral host range

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

Mapping of cellular protein-binding sites on the products of early-region 1A of human adenovirus type 5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

Two regions of the adenovirus early region 1A proteins are required for transformation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

Binding of the Rb1 protein to E1A products is required for adenovirus transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

Analysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

Simian virus 40 large-T antigen expresses a biological activity complementary to the p300-associated transforming function of the adenovirus E1A gene products

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

SV40 T antigen binds directly to the large subunit of purified DNA polymerase alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

The ability of large T antigen to complex with p53 is necessary for the increased life span and partial transformation of human cells by simian virus 40.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

28 May 2018

Two regions of simian virus 40 large T-antigen independently extend the life span of primary C57BL/6 mouse embryo fibroblasts and cooperate in immortalization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738162

16 August 2018

A family of transcriptional adaptor proteins targeted by the E1A oncoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19553311

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenoviral ElA-associated protein p300 as a functional homologue of the transcriptional co-activator CBP

1 reference

https://pubmed.ncbi.nlm.nih.gov/19553311

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19553311

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/JVI.00621-09

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

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