(Q42546531)

English

Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands

scientific article published on 3 February 2016

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scholarly article

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Europe PubMed Central

2 November 2017

Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands (English)

1 reference

Europe PubMed Central

2 November 2017

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based on heuristic

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corrigendum / erratum

Erratum: Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands.

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Rogelio Palomino-Morales

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26838129%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Esperanza Padín-Gonzalez

4

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12 June 2020

David J. Timson

7

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12 June 2020

8

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12 June 2020

author name string

Julian E Fuchs

3

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12 June 2020

Eduardo Salido

6

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12 June 2020

Encarnación Medina-Carmona

1

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12 June 2020

Noel Mesa-Torres

5

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12 June 2020

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publication date

3 February 2016

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Europe PubMed Central

2 November 2017

Scientific Reports

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12 June 2020

6

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Europe PubMed Central

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12 June 2020

20331

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12 June 2020

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4738246/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

https://scigraph.springernature.com/pub.10.1038/srep20331

0 references

PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738246

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Intrinsic flexibility of NLRP pyrin domains is a key factor in their conformational dynamics, fold stability, and dimerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738246

28 May 2018

Regulating the 20S proteasome ubiquitin-independent degradation pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738246

28 May 2018

Collapse of the native structure caused by a single amino acid exchange in human NAD(P)H:quinone oxidoreductase(1.)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738246

28 May 2018

Paradigms of protein degradation by the proteasome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738246

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738246

28 May 2018

The NQO1 polymorphism C609T (Pro187Ser) and cancer susceptibility: a comprehensive meta-analysis

1 reference

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28 May 2018

Entropy from state probabilities: hydration entropy of cations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738246

28 May 2018

Small molecule induced reactivation of mutant p53 in cancer cells

1 reference

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28 May 2018

Dynamic regulation of phenylalanine hydroxylase by simulated redox manipulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738246

28 May 2018

The direction of protein entry into the proteasome determines the variety of products and depends on the force needed to unfold its two termini.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738246

28 May 2018

A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738246

28 May 2018

Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

1 reference

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28 May 2018

Stabilizing of a globular protein by a highly complex water network: a molecular dynamics simulation study on factor Xa.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738246

28 May 2018

Improved side-chain torsion potentials for the Amber ff99SB protein force field

1 reference

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28 May 2018

The NAD(P)H:Quinone Oxidoreductase 1 induces cell cycle progression and proliferation of melanoma cells

1 reference

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28 May 2018

Hidden alternative structures of proline isomerase essential for catalysis

1 reference

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28 May 2018

Protonate3D: assignment of ionization states and hydrogen coordinates to macromolecular structures

1 reference

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28 May 2018

Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential

1 reference

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28 May 2018

20S proteasomal degradation of ornithine decarboxylase is regulated by NQO1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738246

28 May 2018

A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738246

28 May 2018

Implication of alternative splicing for expression of a variant NAD(P)H:quinone oxidoreductase-1 with a single nucleotide polymorphism at 465C>T.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738246

28 May 2018

NQO1 stabilizes p53 through a distinct pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738246

28 May 2018

Rapid polyubiquitination and proteasomal degradation of a mutant form of NAD(P)H:quinone oxidoreductase 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738246

28 May 2018

Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738246

28 May 2018

Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: species comparison and structural changes with substrate binding and release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738246

28 May 2018

Genotype-phenotype relationships in studies of a polymorphism in NAD(P)H:quinone oxidoreductase 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738246

28 May 2018

Involvement of DT-diaphorase (EC 1.6.99.2) in the DNA cross-linking and sequence selectivity of the bioreductive anti-tumour agent EO9

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738246

28 May 2018

Characterization of a polymorphism in NAD(P)H: quinone oxidoreductase (DT-diaphorase).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738246

28 May 2018

Denaturant m values and heat capacity changes: relation to changes in accessible surface areas of protein unfolding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738246

28 May 2018

NAD(P)H:quinone oxidoreductase1 (DT-diaphorase) expression in normal and tumor tissues

1 reference

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28 May 2018

NAD(P)H:quinone oxidoreductase expression and mitomycin C resistance developed by human colon cancer HCT 116 cells

1 reference

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28 May 2018

Modeling studies of the change in conformation required for cleavage of limited proteolytic sites

1 reference

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28 May 2018

A two-domain structure for the two subunits of NAD(P)H:quinone acceptor oxidoreductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738246

28 May 2018

Environment and exposure to solvent of protein atoms. Lysozyme and insulin

1 reference

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28 May 2018

NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity

1 reference

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28 May 2018

The nature of the accessible and buried surfaces in proteins

1 reference

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28 May 2018

Protein co-translocational unfolding depends on the direction of pulling

1 reference

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16 August 2018

FAD binding overcomes defects in activity and stability displayed by cancer-associated variants of human NQO1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738246

16 August 2018

Dynamic activation of an allosteric regulatory protein.

1 reference

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16 August 2018

The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol.

1 reference

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16 August 2018

The association of a distinctive allele of NAD(P)H:quinone oxidoreductase with pediatric acute lymphoblastic leukemias with MLL fusion genes in Japan.

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738246

16 August 2018

Limited proteolysis of cytochrome c in trifluoroethanol.

1 reference

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16 August 2018

NQO1 expression correlates with cholangiocarcinoma prognosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26838129

12 December 2020

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10.1038/SREP20331

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26838129%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26838129%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26838129%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

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