(Q37080932)

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Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential

scientific article published on 13 December 2007

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scholarly article

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Europe PubMed Central

18 August 2017

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Europe PubMed Central

Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential (English)

1 reference

Europe PubMed Central

18 August 2017

Christopher J. Moody

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Christopher J Moody

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author name string

Marie A Colucci

1

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Europe PubMed Central

18 August 2017

Gavin D Couch

3

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Europe PubMed Central

18 August 2017

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publication date

13 December 2007

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Europe PubMed Central

18 August 2017

Organic and Biomolecular Chemistry

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Europe PubMed Central

18 August 2017

6

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Europe PubMed Central

18 August 2017

4

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Europe PubMed Central

18 August 2017

637-656

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Europe PubMed Central

18 August 2017

Microwave-mediated Claisen rearrangement followed by phenol oxidation: a simple route to naturally occurring 1,4-benzoquinones. The first syntheses of verapliquinones A and B and panicein A.

1 reference

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The mitomycin bioreductive antitumor agents: cross-linking and alkylation of DNA as the molecular basis of their activity

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NRH:quinone reductase 2: an enzyme of surprises and mysteries

1 reference

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NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms

1 reference

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21 January 2018

The role of NAD(P)H oxidoreductase (DT-Diaphorase) in the bioactivation of quinone-containing antitumor agents: a review

1 reference

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21 January 2018

Mechanisms of action of quinone-containing alkylating agents. I: NQO1-directed drug development

1 reference

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Quinone reductases multitasking in the metabolic world

1 reference

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21 January 2018

Structures of mammalian cytosolic quinone reductases.

1 reference

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21 January 2018

Crystal structure of human DT-diaphorase: a model for interaction with the cytotoxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)

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21 January 2018

The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction

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21 January 2018

Structure-function studies of DT-diaphorase (NQO1) and NRH: quinone oxidoreductase (NQO2).

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21 January 2018

Aerobic nitroreduction by flavoproteins: enzyme structure, mechanisms and role in cancer chemotherapy

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Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen

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21 January 2018

Functions and distribution of NQO1 in human bone marrow: potential clues to benzene toxicity

1 reference

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21 January 2018

Regulation of genes encoding NAD(P)H:quinone oxidoreductases

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A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure

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Design and synthesis of bifunctional isothiocyanate analogs of sulforaphane: correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes

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21 January 2018

Mechanisms of action of quinone-containing alkylating agents: DNA alkylation by aziridinylquinones

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21 January 2018

Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity

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21 January 2018

Indolequinone antitumor agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase. Part 2.

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21 January 2018

Indolequinone antitumour agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase.

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21 January 2018

A comprehensive study of the active site residues of DT-diaphorase: rational design of benzimidazolediones as DT-diaphorase substrates

1 reference

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21 January 2018

Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex

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21 January 2018

Benzimidazole- and benzothiazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1.

1 reference

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21 January 2018

Role of NAD(P)H:quinone oxidoreductase (DT-diaphorase) in cytotoxicity and induction of DNA damage by streptonigrin

1 reference

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21 January 2018

Novel quinolinequinone antitumor agents: structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1).

1 reference

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21 January 2018

Bioreductive and gene therapy approaches to hypoxic diseases

1 reference

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21 January 2018

Recent advances in bioreductive drug targeting

1 reference

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21 January 2018

Modifying rates of reductive elimination of leaving groups from indolequinone prodrugs: a key factor in controlling hypoxia-selective drug release

1 reference

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21 January 2018

Design, synthesis, and biological evaluation of indolequinone phosphoramidate prodrugs targeted to DT-diaphorase

1 reference

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21 January 2018

Studies on the mechanisms of activation of indolequinone phosphoramidate prodrugs.

1 reference

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21 January 2018

Hypoxia-selective activation of 5-fluorodeoxyuridine prodrug possessing indolequinone structure: radiolytic reduction and cytotoxicity characteristics

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21 January 2018

Bioreduction activated prodrugs of camptothecin: molecular design, synthesis, activation mechanism and hypoxia selective cytotoxicity

1 reference

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21 January 2018

Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin.

1 reference

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21 January 2018

The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol.

1 reference

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21 January 2018

Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches

1 reference

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21 January 2018

Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones

1 reference

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21 January 2018

Biochemical, cytotoxic, and genotoxic effects of ES936, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, in cellular systems

1 reference

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21 January 2018

NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger

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21 January 2018

Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells

1 reference

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21 January 2018

DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90

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21 January 2018

Formation of 17-allylamino-demethoxygeldanamycin (17-AAG) hydroquinone by NAD(P)H:quinone oxidoreductase 1: role of 17-AAG hydroquinone in heat shock protein 90 inhibition

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21 January 2018

Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.

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Structure-Based Development of Anticancer Drugs

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Identifiers

10.1039/B715270A

1 reference

Europe PubMed Central

18 August 2017

1 reference

Europe PubMed Central

18 August 2017

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