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Structure-Based Development of Anticancer Drugs
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title
Structure-Based Development of Anticancer Drugs
(English)
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author
L. Mario Amzel
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stated in
ORCID Public Data File 2021
author name string
Margarita Faig
series ordinal
1
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Mario A. Bianchet
series ordinal
2
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Shannon Winski
series ordinal
3
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Robert Hargreaves
series ordinal
4
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Christopher J. Moody
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5
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Anna R. Hudnott
series ordinal
6
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David Ross
series ordinal
7
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L.Mario Amzel
series ordinal
8
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publication date
August 2001
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published in
Structure
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volume
9
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page(s)
659-667
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issue
8
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cites work
Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues
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The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction
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Molecular basis of the catalytic differences among DT-diaphorase of human, rat, and mouse
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Molecular characterization of binding of substrates and inhibitors to DT-diaphorase: combined approach involving site-directed mutagenesis, inhibitor-binding analysis, and computer modeling
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Bioreductive activation of a series of indolequinones by human DT-diaphorase: structure-activity relationships.
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Crystal structure of human DT-diaphorase: a model for interaction with the cytotoxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)
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Treatment of patients with recurrent primary brain tumors with AZQ.
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Alteration in DNA cross-linking and sequence selectivity of a series of aziridinylbenzoquinones after enzymatic reduction by DT-diaphorase
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Cross-linking and sequence-specific alkylation of DNA by aziridinylquinones. 3. Effects of alkyl substituents
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The Role of NAD(P)H: Quinone Reductase (EC 1.6.99.2, DT-Diaphorase) in the Reductive Bioactivation of the Novel Indoloquinone Antitumor Agent E09
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Indoloquinone EO9: DNA interstrand cross-linking upon reduction by DT-diaphorase or xanthine oxidase
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Indolequinone Antitumor Agents: Correlation between Quinone Structure, Rate of Metabolism by Recombinant Human NAD(P)H:Quinone Oxidoreductase, and in Vitro Cytotoxicity1
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Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development
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Structure-activity relationships for DT-diaphorase reduction of hypoxic cell directed agents: indoloquinones and diaziridinyl benzoquinones
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Expression of rat liver NAD(P)H:quinone-acceptor oxidoreductase in Escherichia coli and mutagenesis in vitro at Arg-177
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Processing of X-ray diffraction data collected in oscillation mode
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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination
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Improved methods for building protein models in electron density maps and the location of errors in these models
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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures
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An extensively modified version of MolScript that includes greatly enhanced coloring capabilities
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inferred from DOI database lookup
The CCP4 suite: programs for protein crystallography
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inferred from DOI database lookup
Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons
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7 January 2021
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DOI
10.1016/S0969-2126(01)00636-0
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