(Q78049595)

English

Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development

scientific article published on 01 July 1999

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10423172%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10423172%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

Roger M. Phillips

1

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10 December 2019

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1 July 1999

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10 December 2019

Biochemical Pharmacology

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10 December 2019

58

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10 December 2019

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10 December 2019

303-310

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10 December 2019

Reduction of tumor blood flow by flavone acetic acid: a possible component of therapy.

1 reference

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7 January 2021

Preclinical in vitro and in vivo activity of 5,6-dimethylxanthenone-4-acetic acid

1 reference

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7 January 2021

Induction of tumour hypoxia by FAA and TNF: interaction with bioreductive drugs

1 reference

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7 January 2021

Combining bioreductive drugs (SR 4233 or SN 23862) with the vasoactive agents flavone acetic acid or 5,6-dimethylxanthenone acetic acid

1 reference

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7 January 2021

Enhancement of the anti-tumour effects of the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by combination with 5-hydroxytryptamine and bioreductive drugs

1 reference

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7 January 2021

Mechanisms of enhancement of the antitumour activity of melphalan by the tumour-blood-flow inhibitor 5,6-dimethylxanthenone-4-acetic acid

1 reference

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7 January 2021

Inhibition of NAD(P)H:quinone acceptor oxidoreductase by flavones: a structure-activity study

1 reference

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7 January 2021

Disruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicity.

1 reference

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7 January 2021

DT-diaphorase as a quinone reductase: a cellular control device against semiquinone and superoxide radical formation

1 reference

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7 January 2021

Bioreductive activation of a series of analogues of 5-aziridinyl-3-hydroxymethyl-1-methyl-2-[1H-indole-4, 7-dione] prop-beta-en-alpha-ol (EO9) by human DT-diaphorase

1 reference

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7 January 2021

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

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7 January 2021

Development and validation of a spectrophotometric assay for measuring the activity of NADH: cytochrome b5 reductase in human tumour cells

1 reference

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7 January 2021

In vitro activity of the novel indoloquinone EO-9 and the influence of pH on cytotoxicity.

1 reference

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7 January 2021

The relationship between tissue levels of flavone acetic acid (NSC 347512) and site dependent anti-tumour activity in murine colon tumours

1 reference

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7 January 2021

Plasma pharmacokinetics of the antitumour agents 5,6-dimethylxanthenone-4-acetic acid, xanthenone-4-acetic acid and flavone-8-acetic acid in mice

1 reference

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7 January 2021

DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9.

1 reference

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7 January 2021

Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin

1 reference

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7 January 2021

Enzymology of the reduction of the potent benzotriazine-di-n-oxide hypoxic cell cytotoxin SR 4233 (win 59075) by NAD(P)H: (Quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from walker 256 rat tumour cells

1 reference

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7 January 2021

Metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) by purified DT-diaphorase under aerobic and anaerobic conditions

1 reference

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7 January 2021

DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C.

1 reference

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7 January 2021

Structure-related inhibition of human hepatic caffeine N3-demethylation by naturally occurring flavonoids

1 reference

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7 January 2021

Identifiers

10.1016/S0006-2952(99)00092-1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10423172%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10423172%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

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