(Q43990738)

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Modifying rates of reductive elimination of leaving groups from indolequinone prodrugs: a key factor in controlling hypoxia-selective drug release

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Europe PubMed Central

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28 November 2017

Modifying rates of reductive elimination of leaving groups from indolequinone prodrugs: a key factor in controlling hypoxia-selective drug release (English)

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Europe PubMed Central

PubMed publication ID

28 November 2017

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Christopher J. Moody

9

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Europe PubMed Central

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28 November 2017

Borivoj Vojnovic

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Borivoj Vojnovic

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Steven A Everett

1

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28 November 2017

Elizabeth Swann

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28 November 2017

Matthew A Naylor

3

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28 November 2017

Michael R L Stratford

4

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28 November 2017

Kantilal B Patel

5

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28 November 2017

Natasha Tian

6

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28 November 2017

Robert G Newman

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28 November 2017

Peter Wardman

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28 November 2017

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1 May 2002

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28 November 2017

Biochemical Pharmacology

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28 November 2017

63

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28 November 2017

9

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28 November 2017

1629-1639

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28 November 2017

Bioreductive activation of a series of analogues of 5-aziridinyl-3-hydroxymethyl-1-methyl-2-[1H-indole-4, 7-dione] prop-beta-en-alpha-ol (EO9) by human DT-diaphorase

1 reference

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7 January 2021

DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C.

1 reference

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7 January 2021

The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900885-7

7 January 2021

EO9: a novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical models

1 reference

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7 January 2021

EO9 phase II study in advanced breast, gastric, pancreatic and colorectal carcinoma by the EORTC Early Clinical Studies Group

1 reference

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7 January 2021

Phase I trial with weekly EO9, a novel bioreductive alkylating indoloquinone, by the EORTC Early Clinical Study Group (ECSG)

1 reference

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7 January 2021

Establishment of an isogenic human colon tumor model for NQO1 gene expression: application to investigate the role of DT-diaphorase in bioreductive drug activation in vitro and in vivo.

1 reference

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7 January 2021

Reduction of the indoloquinone anticancer drug EO9 by purified DT-diaphorase: a detailed kinetic study and analysis of metabolites

1 reference

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7 January 2021

Relative importance of DT-diaphorase and hypoxia in the bioactivation of EO9 by human lung tumor cell lines

1 reference

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7 January 2021

The relative importance of NADPH: cytochrome c (P450) reductase for determining the sensitivity of human tumour cells to the indolequinone EO9 and related analogues lacking functionality at the C-2 and C-3 positions

1 reference

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7 January 2021

Indolequinone Antitumor Agents: Correlation between Quinone Structure, Rate of Metabolism by Recombinant Human NAD(P)H:Quinone Oxidoreductase, and in Vitro Cytotoxicity1

1 reference

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7 January 2021

Bioreductive activation of a series of indolequinones by human DT-diaphorase: structure-activity relationships.

1 reference

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7 January 2021

Indolequinone antitumor agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase. Part 2.

1 reference

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7 January 2021

The autoxidation of the reduced forms of EO9

1 reference

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7 January 2021

Indolequinone Antitumor Agents: Reductive Activation and Elimination from (5-Methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl Derivatives and Hypoxia-Selective Cytotoxicity in Vitro

1 reference

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7 January 2021

Prodrugs for targeting hypoxic tissues: regiospecific elimination of aspirin from reduced indolequinones

1 reference

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7 January 2021

Electron transfer and oxidative stress as key factors in the design of drugs selectively active in hypoxia

1 reference

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7 January 2021

2-Cyclopropylindoloquinones and their analogues as bioreductively activated antitumor agents: structure-activity in vitro and efficacy in vivo

1 reference

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7 January 2021

Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein

1 reference

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7 January 2021

Production of reactive oxygen species by microsomes enriched in specific human cytochrome P450 enzymes

1 reference

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7 January 2021

Studies on the mechanisms of thallium-mediated inhibition of hepatic mixed function oxidase activity. Correlation with inhibition of NADPH-cytochrome c (P-450) reductase

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7 January 2021

Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: correlation with sensitivity to mitomycin C and EO9.

1 reference

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7 January 2021

Structure-function analysis of human cytochrome P450 3A4 using 7-alkoxycoumarins as active-site probes

1 reference

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7 January 2021

Bioreductive metabolism of the novel fluorinated 2-nitroimidazole hypoxia probe N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitroimidazolyl) acetamide (SR-4554)

1 reference

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7 January 2021

The experimental development of bioreductive drugs and their role in cancer therapy.

1 reference

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7 January 2021

Identifiers

10.1016/S0006-2952(02)00885-7

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Europe PubMed Central

PubMed publication ID

28 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

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