(Q42557866)

English

Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu4) antagonist: unexpected 'molecular switch' from a closely related mGlu4 positive allosteric modulator

scientific article published on 8 October 2011

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu4) antagonist: unexpected 'molecular switch' from a closely related mGlu4 positive allosteric modulator (English)

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

Colleen M. Niswender

8

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Colleen M Niswender

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

Craig W. Lindsley

6

object named as

Craig W Lindsley

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

Corey R. Hopkins

7

object named as

Corey R Hopkins

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

4

object named as

Rocio Zamorano

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

James M Salovich

3

object named as

James M Salovich

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

author name string

Thomas Utley

1

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

Dustin Haddenham

2

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

Paige N Vinson

5

1 reference

Europe PubMed Central

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2 November 2017

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publication date

8 October 2011

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Europe PubMed Central

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2 November 2017

Bioorganic & Medicinal Chemistry Letters

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Europe PubMed Central

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2 November 2017

21

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

23

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

6955-6959

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

"Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319082

28 May 2018

Discovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319082

28 May 2018

Chemical switch of a metabotropic glutamate receptor 2 silent allosteric modulator into dual metabotropic glutamate receptor 2/3 negative/positive allosteric modulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319082

28 May 2018

mGluR4-positive allosteric modulation as potential treatment for Parkinson's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319082

28 May 2018

Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a series of functionalized, regioisomeric 2- and 5-(phenylethynyl)pyrimidines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319082

28 May 2018

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319082

28 May 2018

Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319082

28 May 2018

A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319082

28 May 2018

Identifiers

10.1016/J.BMCL.2011.09.131

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

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