(Q42583215)

3 November 2017

The National Institutes of Health Microphysiological Systems Program focuses on a critical challenge in the drug discovery pipeline (English)

1 reference

3 November 2017

1 reference

Margaret L Sutherland

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1

1 reference

3 November 2017

Kristin M Fabre

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2

1 reference

3 November 2017

Danilo A Tagle

series ordinal

3

1 reference

3 November 2017

20 December 2013

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Stem Cell Research & Therapy

3 November 2017

1 reference

3 November 2017

4 Suppl 1

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3 November 2017

I1

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https://scigraph.springernature.com/pub.10.1186/scrt361

3 November 2017

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cites work

Reengineering translational science: the time is right

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029183

Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029183

Metabolic detoxification determines species differences in coumarin-induced hepatotoxicity

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029183

Timing of new black box warnings and withdrawals for prescription medications

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029183

Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029183

Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: effects on coumarin, dicumarol, and testosterone oxidation

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029183

Trial watch: Phase II failures: 2008-2010.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029183

Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029183

Phase III and submission failures: 2007–2010

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029183

Safety of newly approved drugs: implications for prescribing

30 September 2018

1 reference

12 December 2020

Myelotoxic effects of the bifunctional alkylating agent bizelesin on human, canine and murine myeloid progenitor cells

1 reference

12 December 2020

Overview: Evaluation of metabolism-based drug toxicity in drug development

1 reference

12 December 2020

Quantitative prediction of mechanism-based inhibition caused by mibefradil in rats

1 reference

12 December 2020

Identifiers

DOI

10.1186/SCRT361

1 reference

Dimensions Publication ID

3 November 2017

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/scrt361

1 reference

3 November 2017

PubMed publication ID

24565163

1 reference