(Q42600454)

English

Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae

scientific article published on May 1999

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scholarly article

1 reference

Europe PubMed Central

3 November 2017

Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae (English)

1 reference

Europe PubMed Central

3 November 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

5

1 reference

Europe PubMed Central

3 November 2017

author name string

Kündig C

1

1 reference

Europe PubMed Central

3 November 2017

Haimeur A

2

1 reference

Europe PubMed Central

3 November 2017

Légaré D

3

1 reference

Europe PubMed Central

3 November 2017

Papadopoulou B

4

1 reference

Europe PubMed Central

3 November 2017

language of work or name

0 references

publication date

1 May 1999

1 reference

Europe PubMed Central

3 November 2017

The EMBO Journal

1 reference

Europe PubMed Central

3 November 2017

18

1 reference

Europe PubMed Central

3 November 2017

9

1 reference

Europe PubMed Central

3 November 2017

2342-2351

1 reference

Europe PubMed Central

3 November 2017

The flagellar pocket of trypanosomatids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

LD1 amplifications in Leishmania

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

New approaches to Leishmania chemotherapy: pteridine reductase 1 (PTR1) as a target and modulator of antifolate sensitivity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

Selection against the dihydrofolate reductase-thymidylate synthase (DHFR-TS) locus as a probe of genetic alterations in Leishmania major.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

Intrinsic and acquired resistance to methotrexate in acute leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

Formation of extrachromosomal circular amplicons with direct or inverted duplications in drug-resistant Leishmania tarentolae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

New mechanisms of drug resistance in parasitic protozoa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

Increased expression of LD1 genes transcribed by RNA polymerase I in Leishmania donovani as a result of duplication into the rRNA gene locus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

Frequent amplification of a short chain dehydrogenase gene as part of circular and linear amplicons in methotrexate resistant Leishmania

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

Shuttle cosmid vectors for the trypanosomatid parasite Leishmania

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

Frequent amplification of a short chain dehydrogenase gene in methotrexate resistant Leishmania

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

A new VSG expression site-associated gene (ESAG) in the promoter region of Trypanosoma brucei encodes a protein with 10 potential transmembrane domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

Isolation and characterization of a mutant dihydrofolate reductase-thymidylate synthase from methotrexate-resistant Leishmania cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

An amplified DNA element in Leishmania encodes potential integral membrane and nucleotide-binding proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

P-glycoprotein overexpression in methotrexate-resistant Leishmania tropica

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

Differential targeting of two glucose transporters from Leishmania enriettii is mediated by an NH2-terminal domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

A simple method for displaying the hydropathic character of a protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

In vitro activity of sulfonamides and sulfones against Leishmania major promastigotes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

Biochemistry and regulation of folate and methotrexate transport in Leishmania major

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

Wild-type and drug-resistant Leishmania major hydrolyze methotrexate to N-10-methyl-4-deoxy-4-aminopteroate without accumulation of methotrexate polyglutamates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

The structure and insertion of integral proteins in membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

Dihydrofolate reductase as a therapeutic target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

Nutritional requirements of wild-type and folate transport-deficient Leishmania donovani for pterins and folates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

RNA polymerase I can mediate expression of CAT and neo protein-coding genes in Trypanosoma brucei

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

Biopterin conversion to reduced folates by Leishmania donovani promastigotes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

Gene amplification in Leishmania

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

A novel antifolate resistance gene on the amplified H circle of Leishmania.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

A member of the aldoketo reductase family confers methotrexate resistance in Leishmania

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

Cultivation and in vitro cloning or procyclic culture forms of Trypanosoma brucei in a semi-defined medium. Short communication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

The H circles of Leishmania tarentolae are a unique amplifiable system of oligomeric DNAs associated with drug resistance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

Pterin and folate reduction by the Leishmania tarentolae H locus short-chain dehydrogenase/reductase PTR1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

Reductions in methotrexate and folate influx in methotrexate-resistant lines of Leishmania major are independent of R or H region amplification.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

Methotrexate-resistant Leishmania donovani genetically deficient in the folate-methotrexate transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

28 May 2018

Changes in folate and pterin metabolism after disruption of the Leishmania H locus short chain dehydrogenase gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

16 August 2018

High level arsenite resistance in Leishmania tarentolae is mediated by an active extrusion system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171317

16 August 2018

Impaired drug uptake in methotrexate resistant Crithidia fasciculata without changes in dihydrofolate reductase activity or gene amplification

1 reference

https://pubmed.ncbi.nlm.nih.gov/10228149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autonomous replication of bacterial DNA plasmid oligomers in Leishmania

1 reference

https://pubmed.ncbi.nlm.nih.gov/10228149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioassay of the folate-hydrolyzing enzyme activity, and the distribution of the enzyme in biological cells and tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/10228149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of de novo folate synthesis in Pneumocystis carinii and Toxoplasma gondii: potential for screening therapeutic agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/10228149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of methotrexate and other antifolates on the growth and dihydrofolate reductase activity of Leishmania promastigotes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10228149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pteridine Requirement of the HemoflagellateLeishmania tarentolae

1 reference

https://pubmed.ncbi.nlm.nih.gov/10228149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circular and linear multicopy DNAs in Leishmania

1 reference

https://pubmed.ncbi.nlm.nih.gov/10228149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug resistance in Leishmania: similarities and differences to other organisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/10228149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficient production of functional mRNA mediated by RNA polymerase I in Trypanosoma brucei

1 reference

https://pubmed.ncbi.nlm.nih.gov/10228149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/EMBOJ/18.9.2342

1 reference

Europe PubMed Central

3 November 2017

1 reference

Europe PubMed Central

3 November 2017

1 reference

Europe PubMed Central

3 November 2017

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