(Q42635564)

4 November 2017

What are pharmacological chaperones and why are they interesting? (English)

1 reference

4 November 2017

0 references

1 reference

2

Gregory A Petsko

1 reference

4 November 2017

1

Dagmar Ringe

1 reference

4 November 2017

language of work or name

1 reference

13 October 2009

1 reference

4 November 2017

1 reference

4 November 2017

8

1 reference

4 November 2017

9

1 reference

4 November 2017

80

1 reference

Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase

4 November 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2776907

Converging concepts of protein folding in vitro and in vivo

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2776907

Protein misfolding in conformational disorders: rescue of folding defects and chemical chaperoning

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2776907

A counterintuitive approach to treat enzyme deficiencies: use of enzyme inhibitors for restoring mutant enzyme activity

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2776907

Active-site-specific chaperone therapy for Fabry disease. Yin and Yang of enzyme inhibitors

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2776907

Chemical and pharmacological chaperones as new therapeutic agents

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2776907

Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2776907

Small molecule pharmacological chaperones: From thermodynamic stabilization to pharmaceutical drugs.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2776907

The iminosugar isofagomine increases the activity of N370S mutant acid beta-glucosidase in Gaucher fibroblasts by several mechanisms

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2776907

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2776907

Ligand effects on protein thermodynamic stability.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2776907

Therapy through chaperones: sense or antisense? Cystic fibrosis as a model disease

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2776907

Protein-misfolding diseases and chaperone-based therapeutic approaches

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2776907

Therapeutic strategies to ameliorate lysosomal storage disorders--a focus on Gaucher disease

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2776907

Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2776907

Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2776907

Therapeutic approaches to protein-misfolding diseases

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2776907

Macromolecular crowding: an important but neglected aspect of the intracellular environment

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2776907

What makes a binding site a binding site?

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2776907

Multiple solvent crystal structures: probing binding sites, plasticity and hydration

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2776907

Mechanisms underlying responsiveness to tetrahydrobiopterin in mild phenylketonuria mutations

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2776907

Treatment perspectives for the lysosomal storage diseases

16 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19833004

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A Role for Protein Misfolding in Immunogenicity of Biopharmaceuticals

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19833004

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/JBIOL186

1 reference

Dimensions Publication ID

4 November 2017

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/jbiol186

1 reference

4 November 2017

PubMed publication ID

19833004

1 reference