(Q42657454)

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HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRα and PPARα dysregulation: implications for HIV-specific pathogenesis of NAFLD.

scientific article published on 17 October 2017

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scholarly article

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Europe PubMed Central

4 November 2017

HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRα and PPARα dysregulation: implications for HIV-specific pathogenesis of NAFLD. (English)

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Europe PubMed Central

4 November 2017

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Chiara Gabbi

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author name string

Neeti Agarwal

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Europe PubMed Central

4 November 2017

Dinakar Iyer

2

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Europe PubMed Central

4 November 2017

Pradip Saha

4

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4 November 2017

Sanjeet G Patel

5

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Europe PubMed Central

4 November 2017

Qianxing Mo

6

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4 November 2017

Benny Chang

7

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Europe PubMed Central

4 November 2017

Biman Goswami

8

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4 November 2017

Ulrich Schubert

9

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Europe PubMed Central

4 November 2017

Jeffrey B Kopp

10

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4 November 2017

Dorothy E Lewis

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4 November 2017

Ashok Balasubramanyam

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4 November 2017

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17 October 2017

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4 November 2017

Scientific Reports

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4 November 2017

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4 November 2017

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4 November 2017

13362

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Europe PubMed Central

4 November 2017

copyright license

Creative Commons Attribution 4.0 International

17 October 2017

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April 2022 Public Data File from Crossref

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https://scigraph.springernature.com/pub.10.1038/s41598-017-13835-w

0 references

Prevalence and predictors of liver steatosis and fibrosis in unselected patients with HIV mono-infection.

1 reference

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27 May 2018

Nonalcoholic fatty liver disease diagnosed by transient elastography with controlled attenuation parameter in unselected HIV monoinfected patients.

1 reference

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27 May 2018

Valproic acid and nonalcoholic fatty liver disease: A possible association?

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27 May 2018

Nonalcoholic Steatohepatitis and Hepatic Fibrosis in HIV-1-Monoinfected Adults With Elevated Aminotransferase Levels on Antiretroviral Therapy

1 reference

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27 May 2018

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

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27 May 2018

High dietary protein intake, reducing or eliciting insulin resistance?

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27 May 2018

New clues to understanding HIV nonprogressors: low cholesterol blocks HIV trans infection

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27 May 2018

HIV-1 Vpr-a still "enigmatic multitasker".

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27 May 2018

HIV-1 Vpr induces adipose dysfunction in vivo through reciprocal effects on PPAR/GR co-regulation

1 reference

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27 May 2018

Human immunodeficiency virus and liver disease forum 2012.

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27 May 2018

De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health

1 reference

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27 May 2018

Dietary protein affects gene expression and prevents lipid accumulation in the liver in mice

1 reference

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27 May 2018

STAR: ultrafast universal RNA-seq aligner

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27 May 2018

HIV-1 Vpr triggers mitochondrial destruction by impairing Mfn2-mediated ER-mitochondria interaction

1 reference

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27 May 2018

Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential

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27 May 2018

Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor α in mouse liver reveals extensive sharing of binding sites

1 reference

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27 May 2018

Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c

1 reference

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27 May 2018

Human immunodeficiency virus (HIV)-1 infects human hepatic stellate cells and promotes collagen I and monocyte chemoattractant protein-1 expression: implications for the pathogenesis of HIV/hepatitis C virus-induced liver fibrosis

1 reference

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27 May 2018

Nonalcoholic fatty liver disease among HIV-infected persons

1 reference

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27 May 2018

Steatohepatitis: Risk factors and impact on disease severity in human immunodeficiency virus/hepatitis C virus coinfection

1 reference

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27 May 2018

SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

27 May 2018

The prevalence and risk factors for abnormal liver enzymes in HIV-positive patients without hepatitis B or C coinfections

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

27 May 2018

Compartmentalization of hepatitis C virus (HCV) during HCV/HIV coinfection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

27 May 2018

Pathology of fatty liver disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

27 May 2018

Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

27 May 2018

The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

27 May 2018

Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

27 May 2018

Acute fatty liver of pregnancy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

27 May 2018

Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

27 May 2018

Activation of peroxisome proliferator-activated receptor alpha increases the expression and activity of microsomal triglyceride transfer protein in the liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

27 May 2018

A simple method for the isolation and purification of total lipides from animal tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

27 May 2018

HIV lipodystrophy: risk factors, pathogenesis, diagnosis and management.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

27 May 2018

HIV-1 Vpr displays natural protein-transducing properties: implications for viral pathogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

27 May 2018

Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

27 May 2018

Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

27 May 2018

Role of LXRs in control of lipogenesis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

27 May 2018

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

27 May 2018

Functional and structural characterization of synthetic HIV-1 Vpr that transduces cells, localizes to the nucleus, and induces G2 cell cycle arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

27 May 2018

The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

27 May 2018

Sterol regulatory element-binding protein negatively regulates microsomal triglyceride transfer protein gene transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

27 May 2018

Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

27 May 2018

Cell cycle arrest by Vpr in HIV-1 virions and insensitivity to antiretroviral agents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

27 May 2018

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

27 May 2018

PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene

1 reference

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27 May 2018

Sterol synthesis in vivo in 18 tissues of the squirrel monkey, guinea pig, rabbit, hamster, and rat.

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27 May 2018

Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia

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27 May 2018

Glycerolipid biosynthesis in rat adipose tissue. Influence of adipose-cell size and site of adipose tissue on triacylglycerol formation in lean and obese rats

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27 May 2018

Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

16 August 2018

Prospective evaluation of hepatic steatosis in HIV-infected patients with or without hepatitis C virus co-infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

16 August 2018

Nonalcoholic fatty liver disease in HIV-infected patients referred to a metabolic clinic: prevalence, characteristics, and predictors

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16 August 2018

Magnetic resonance spectroscopy of hepatic lipid content and associated risk factors in HIV infection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

16 August 2018

Severely dysregulated disposal of postprandial triacylglycerols exacerbates hypertriacylglycerolemia in HIV lipodystrophy syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

16 August 2018

LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

16 August 2018

Visceral adiposity, C-peptide levels, and low lipase activities predict HIV-dyslipidemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

16 August 2018

Metabolic basis of HIV-lipodystrophy syndrome

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645472

16 August 2018

Effects of transgenic expression of HIV-1 Vpr on lipid and energy metabolism in mice

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https://api.crossref.org/works/10.1038%2FS41598-017-13835-W

21 January 2018

Effects of bile duct ligation and cholic acid treatment on fatty liver in two rat models of non-alcoholic fatty liver disease

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-13835-W

7 January 2021

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10.1038/S41598-017-13835-W

1 reference

Europe PubMed Central

4 November 2017

1 reference

Europe PubMed Central

4 November 2017

1 reference

Europe PubMed Central

4 November 2017

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