(Q42663487)

English

Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis

scientific article published on 2 June 2010

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

4 November 2017

Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis (English)

1 reference

Europe PubMed Central

PMC publication ID

4 November 2017

0 references

1

object named as

Fiona E McCann

1 reference

Europe PubMed Central

PMC publication ID

4 November 2017

author name string

Andrew C Palfreeman

2

1 reference

Europe PubMed Central

PMC publication ID

4 November 2017

Melanie Andrews

3

1 reference

Europe PubMed Central

PMC publication ID

4 November 2017

Dany P Perocheau

4

1 reference

Europe PubMed Central

PMC publication ID

4 November 2017

Julia J Inglis

5

1 reference

Europe PubMed Central

PMC publication ID

4 November 2017

Peter Schafer

6

1 reference

Europe PubMed Central

PMC publication ID

4 November 2017

Marc Feldmann

7

1 reference

Europe PubMed Central

PMC publication ID

4 November 2017

Richard O Williams

8

1 reference

Europe PubMed Central

PMC publication ID

4 November 2017

Fionula M Brennan

9

1 reference

Europe PubMed Central

PMC publication ID

4 November 2017

publication date

2 June 2010

1 reference

Europe PubMed Central

PMC publication ID

4 November 2017

Arthritis Research and Therapy

1 reference

Europe PubMed Central

PMC publication ID

4 November 2017

12

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Europe PubMed Central

PMC publication ID

4 November 2017

3

1 reference

Europe PubMed Central

PMC publication ID

4 November 2017

R107

1 reference

Europe PubMed Central

PMC publication ID

4 November 2017

https://scigraph.springernature.com/pub.10.1186/ar3041

0 references

Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

27 May 2018

Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4 and tumor necrosis factor-alpha inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

27 May 2018

PDE4 inhibitors: current status

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

27 May 2018

Potential of phosphodiesterase type of IV inhibitors in the treatment of rheumatoid arthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

27 May 2018

PDE4 inhibitors as potential therapeutic agents in the treatment of COPD-focus on roflumilast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

27 May 2018

Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

27 May 2018

Collagen-induced arthritis in mice: a major role for tumor necrosis factor-alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

27 May 2018

Keynote review: phosphodiesterase-4 as a therapeutic target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

27 May 2018

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

27 May 2018

Life after PDE4: overcoming adverse events with dual-specificity phosphodiesterase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

27 May 2018

Cyclic nucleotide phosphodiesterases and their role in immunomodulatory responses: advances in the development of specific phosphodiesterase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

27 May 2018

The effects of selective cytokine inhibitory drugs (CC-10004 and CC-1088) on VEGF and IL-6 expression and apoptosis in myeloma and endothelial cell co-cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

27 May 2018

Impact of VIP and cAMP on the regulation of TNF-alpha and IL-10 production: implications for rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

27 May 2018

Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

27 May 2018

In vivo efficacy in airway disease models of roflumilast, a novel orally active PDE4 inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

27 May 2018

Molecular diversity of cyclic AMP signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

27 May 2018

The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-alpha production by human mononuclear cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

27 May 2018

PDE isoenzymes as targets for anti-asthma drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

27 May 2018

Oxpentifylline in endotoxaemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

27 May 2018

Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

27 May 2018

An open-label, single-arm pilot study in patients with severe plaque-type psoriasis treated with an oral anti-inflammatory agent, apremilast.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

16 August 2018

Collagen-induced arthritis as a model of hyperalgesia: functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

16 August 2018

Further validation of LABORAS using various dopaminergic manipulations in mice including MPTP-induced nigro-striatal degeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

16 August 2018

Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

16 August 2018

Cyclic nucleotide research -- still expanding after half a century

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

16 August 2018

Anti-TNF-alpha properties of new 9-benzyladenine derivatives with selective phosphodiesterase-4- inhibiting properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

16 August 2018

Effects of the phosphodiesterase inhibitor rolipram on streptococcal cell wall-induced arthritis in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

16 August 2018

Rapid assessment of islet cell viability by MTT assay after cold storage in different solutions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911898

16 August 2018

Preparation of mononuclear cells from synovial tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/20525198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation is preceded by tumor necrosis factor-dependent infiltration of mesenchymal cells in experimental arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20525198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amelioration of collagen-induced arthritis in mice by a novel phosphodiesterase 7 and 4 dual inhibitor, YM-393059

1 reference

https://pubmed.ncbi.nlm.nih.gov/20525198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of cAMP-dependent inhibition of LPS-induced TNF alpha production by rolipram, a specific phosphodiesterase IV (PDE IV) inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/20525198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of TNF-alpha expression, inhibition of Th1 activity, and amelioration of collagen-induced arthritis by rolipram

1 reference

https://pubmed.ncbi.nlm.nih.gov/20525198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of TNF alpha and IL-1 beta from endotoxin-stimulated monocytes by selective PDE isozyme inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20525198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Collagen-induced arthritis in mice: synergistic effect of E. coli lipopolysaccharide bypasses epitope specificity in the induction of arthritis with monoclonal antibodies to type II collagen

1 reference

https://pubmed.ncbi.nlm.nih.gov/20525198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Validation of a new system for the automatic registration of behaviour in mice and rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/20525198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-inflammatory and analgesic effects of the phosphodiesterase 4 inhibitor rolipram in a rat model of arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20525198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-inflammatory activity of phosphodiesterase (PDE)-IV inhibitors in acute and chronic models of inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20525198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine production in culture by cells isolated from the synovial membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/20525198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of lipopolysaccharide-induced tumor necrosis factor-alpha generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: interaction with stimulants of adenylyl cyclase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20525198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

Europe PubMed Central

PMC publication ID

4 November 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

4 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

4 November 2017

ResearchGate publication ID

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