(Q42687946)

English

Binding of the anticonvulsant drug lamotrigine and the neurotoxin batrachotoxin to voltage-gated sodium channels induces conformational changes associated with block and steady-state activation.

scientific article published on 12 November 2002

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12431988%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

Binding of the anticonvulsant drug lamotrigine and the neurotoxin batrachotoxin to voltage-gated sodium channels induces conformational changes associated with block and steady-state activation (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12431988%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

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inferred from title

Andrias O O'Reilly

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12431988%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

Bonnie Ann Wallace

4

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12431988%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

author name string

Nora B Cronin

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12431988%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

Hervé Duclohier

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12431988%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

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publication date

12 November 2002

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14 December 2019

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8

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Journal of Biological Chemistry

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12431988%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

278

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12431988%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

12

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12431988%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

10675-10682

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12431988%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

The cardiac sodium channel: gating function and molecular pharmacology

1 reference

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21 January 2018

Nomenclature of voltage-gated sodium channels

1 reference

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21 January 2018

Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence

1 reference

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21 January 2018

Amino acid residues required for fast Na(+)-channel inactivation: charge neutralizations and deletions in the III-IV linker

1 reference

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21 January 2018

1H-NMR and circular dichroism spectroscopic studies on changes in secondary structures of the sodium channel inactivation gate peptides as caused by the pentapeptide KIFMK.

1 reference

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21 January 2018

A carboxy-terminal alpha-helical segment in the rat skeletal muscle voltage-dependent Na+ channel is responsible for its interaction with the amino-terminus

1 reference

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21 January 2018

The voltage-sensitive sodium channel is a bell-shaped molecule with several cavities

1 reference

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21 January 2018

Structural and functional modularity of voltage-gated potassium channels

1 reference

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21 January 2018

Medicinal chemistry of neuronal voltage-gated sodium channel blockers

1 reference

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21 January 2018

Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na(+) channel alpha subunit.

1 reference

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21 January 2018

Toxins that modulate the sodium channel gating mechanism.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Rapid and slow voltage-dependent conformational changes in segment IVS6 of voltage-gated Na(+) channels

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Affinity purification of the voltage-sensitive sodium channel from electroplax with resins selective for sialic acid

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

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21 January 2018

Ultrasensitive stain for proteins in polyacrylamide gels shows regional variation in cerebrospinal fluid proteins

1 reference

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21 January 2018

Measurement of protein using bicinchoninic acid

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Circular dichroism analyses of membrane proteins: an examination of differential light scattering and absorption flattening effects in large membrane vesicles and membrane sheets.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

DICHROWEB: an interactive website for the analysis of protein secondary structure from circular dichroism spectra.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Estimation of the number of alpha-helical and beta-strand segments in proteins using circular dichroism spectroscopy

1 reference

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21 January 2018

Estimation of globular protein secondary structure from circular dichroism.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Evaluation of secondary structure of proteins from UV circular dichroism spectra using an unsupervised learning neural network.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

ALSCRIPT: a tool to format multiple sequence alignments

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

The open pore conformation of potassium channels

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Comparative protein modelling by satisfaction of spatial restraints

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Automated docking of flexible ligands: applications of AutoDock

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

The CCP4 suite: programs for protein crystallography

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Purified and unpurified sodium channels from eel electroplax in planar lipid bilayers

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Single sodium channels from human ventricular muscle in planar lipid bilayers

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Batrachotoxin-resistant Na+ channels derived from point mutations in transmembrane segment D4-S6

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Residues in Na(+) channel D3-S6 segment modulate both batrachotoxin and local anesthetic affinities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Point mutations in segment I-S6 render voltage-gated Na+ channels resistant to batrachotoxin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Clockwise domain arrangement of the sodium channel revealed by (mu)-conotoxin (GIIIA) docking orientation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Identification of a novel voltage-gated Na+ channel rNa(v)1.5a in the rat hippocampal progenitor stem cell line HiB5.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Interaction of the antiepileptic drug lamotrigine with recombinant rat brain type IIA Na+ channels and with native Na+ channels in rat hippocampal neurones

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

A "minimal" sodium channel construct consisting of ligated S5-P-S6 segments forms a toxin-activatable ionophore

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Structure and function of voltage-dependent ion channel regulatory beta subunits

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Structural rearrangements underlying K+-channel activation gating

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Activation-dependent subconductance levels in the drk1 K channel suggest a subunit basis for ion permeation and gating

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

A critical role for the S4-S5 intracellular loop in domain IV of the sodium channel alpha-subunit in fast inactivation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

1 reference

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21 January 2018

Smoothing and Differentiation of Data by Simplified Least Squares Procedures

1 reference

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21 January 2018

Structural parts involved in activation and inactivation of the sodium channel

1 reference

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21 January 2018

Secondary structure of the human cardiac Na+ channel C terminus: evidence for a role of helical structures in modulation of channel inactivation

1 reference

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21 January 2018

Principal glycopeptide of the tetrodotoxin/saxitoxin binding protein from Electrophorus electricus: isolation and partial chemical and physical characterization

1 reference

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21 January 2018

Estimation of protein secondary structure and error analysis from circular dichroism spectra

1 reference

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21 January 2018

Estimation of protein secondary structure from circular dichroism spectra: inclusion of denatured proteins with native proteins in the analysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Differential absorption flattening optical effects are significant in the circular dichroism spectra of large membrane fragments

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208356200

21 January 2018

Determination of protein secondary structure in solution by vacuum ultraviolet circular dichroism

1 reference

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21 January 2018

Differential light scattering and absorption flattening optical effects are minimal in the circular dichroism spectra of small unilamellar vesicles

1 reference

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21 January 2018

Secondary solvent effects on the circular dichroism spectra of polypeptides in non-aqueous environments: influence of polarisation effects on the far ultraviolet spectra of alamethicin

1 reference

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21 January 2018

Blocker protection in the pore of a voltage-gated K+ channel and its structural implications

1 reference

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21 January 2018

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