(Q42701595)

English

Early clinical evaluation of the intranasal TLR7 agonist GSK2245035: Use of translational biomarkers to guide dosing and confirm target engagement

scientific article published on 5 June 2015

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

5 November 2017

Early clinical evaluation of the intranasal TLR7 agonist GSK2245035: Use of translational biomarkers to guide dosing and confirm target engagement (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 November 2017

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toll-like receptor

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author name string

D Tsitoura

1

1 reference

Europe PubMed Central

PubMed publication ID

5 November 2017

C Ambery

2

1 reference

Europe PubMed Central

PubMed publication ID

5 November 2017

M Price

3

1 reference

Europe PubMed Central

PubMed publication ID

5 November 2017

W Powley

4

1 reference

Europe PubMed Central

PubMed publication ID

5 November 2017

S Garthside

5

1 reference

Europe PubMed Central

PubMed publication ID

5 November 2017

K Biggadike

6

1 reference

Europe PubMed Central

PubMed publication ID

5 November 2017

D Quint

7

1 reference

Europe PubMed Central

PubMed publication ID

5 November 2017

language of work or name

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publication date

5 June 2015

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Europe PubMed Central

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5 November 2017

Clinical Pharmacology & Therapeutics

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Europe PubMed Central

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5 November 2017

98

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Europe PubMed Central

PubMed publication ID

5 November 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

5 November 2017

369-380

1 reference

Europe PubMed Central

PubMed publication ID

5 November 2017

Molecular and cellular mechanisms of allergic disease

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

21 January 2018

The role of T lymphocytes in asthma

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

21 January 2018

Toll-like receptor ligands and atopy: a coin with at least two sides

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

21 January 2018

Toll-like receptors--novel targets in allergic airway disease (probiotics, friends and relatives).

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

21 January 2018

Role of adapters in Toll-like receptor signalling

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

21 January 2018

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

1 reference

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21 January 2018

First in human phase I trial of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced cancer.

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

21 January 2018

The innate immune response, clinical outcomes, and ex vivo HCV antiviral efficacy of a TLR7 agonist (PF-4878691).

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

21 January 2018

Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

21 January 2018

Pollinex Quattro: an innovative four injections immunotherapy in allergic rhinitis

1 reference

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21 January 2018

Assessment of clinical efficacy of CYT003-QbG10 in patients with allergic rhinoconjunctivitis: a phase IIb study.

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

21 January 2018

The novel TLR-9 agonist QbG10 shows clinical efficacy in persistent allergic asthma

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

21 January 2018

TLR7 ligand prevents allergen-induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway.

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

21 January 2018

Toll-like receptors 7, 8, and 9: linking innate immunity to autoimmunity

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

21 January 2018

Expression and function of Toll-like receptors on dendritic cells and other antigen presenting cells from non-human primates

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

21 January 2018

Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

21 January 2018

VTX-1463, a novel TLR8 agonist for the treatment of allergic rhinitis

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

21 January 2018

A new era of targeting the ancient gatekeepers of the immune system: toll-like agonists in the treatment of allergic rhinitis and asthma

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

21 January 2018

Toll-like receptor 7 function is reduced in adolescents with asthma.

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

21 January 2018

Plasmacytoid dendritic cells in allergic asthma and the role of inhaled corticosteroid treatment.

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

21 January 2018

Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

21 January 2018

MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

21 January 2018

Toll-like receptor (TLR) response tolerance: a key physiological "damage limitation" effect and an important potential opportunity for therapy.

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

21 January 2018

Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

21 January 2018

MicroRNA in TLR signaling and endotoxin tolerance.

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

21 January 2018

Safety, pharmacokinetics and pharmacodynamics of GS-9620, an oral Toll-like receptor 7 agonist

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

21 January 2018

Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

21 January 2018

Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

7 January 2021

based on heuristic

inferred from DOI database lookup

Chronic Asthma–induced Airway Remodeling Is Prevented by Toll-like Receptor-7/8 Ligand S28463

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

7 January 2021

based on heuristic

inferred from DOI database lookup

Toll-like receptor 7-triggered immune response in the lung mediates acute and long-lasting suppression of experimental asthma

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

7 January 2021

based on heuristic

inferred from DOI database lookup

TLR agonist mediated suppression of allergic responses is associated with increased innate inflammation in the airways

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction of cytokines in cynomolgus monkeys by the immune response modifiers, imiquimod, S-27609 and S-28463

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

7 January 2021

based on heuristic

inferred from DOI database lookup

Toll-like receptor interactions: tolerance of MyD88-dependent cytokines but enhancement of MyD88-independent interferon-beta production

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

7 January 2021

based on heuristic

inferred from DOI database lookup

Systemic cancer therapy with a small molecule agonist of toll-like receptor 7 can be improved by circumventing TLR tolerance

1 reference

https://api.crossref.org/works/10.1002%2FCPT.157

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/CPT.157

1 reference

Europe PubMed Central

PubMed publication ID

5 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 November 2017

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